Levolin Inhalator

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What Is Levolin Inhaler?

Levolin Inhaler is a pressurised metered-dose inhaler (HFA pMDI) geproduceerd door Cipla at WHO-GMP certified facilities. Each inhaler delivers 50 mcg per actuation van levosalbutamol. levosalbutamol is on the WHO List of Essential Medicines and is the world’s most-used reliever medication for asthma and reversible airflow obstruction.

Levosalbutamol is the pharmacologically active R-(−)-enantiomer of salbutamol. Standard salbutamol is a 50:50 racemic mixture of R and S isomers; the S-isomer contributes nothing to bronchodilation but may worsen airway hyperreactivity in some patients. By using only the R-isomer, levosalbutamol delivers the same therapeutic effect at half the milligram dose, with potentially less tremor and tachycardia in sensitive patients (especially children and those with cardiovascular comorbidities).

How Does Levolin Inhaler Work?

levosalbutamol selectively activates beta-2 adrenergic receptors on the smooth muscle that rings the bronchial airways. Receptor activation raises intracellular cyclic AMP, smooth muscle relaxes, and the airway lumen widens — this is bronchodilation. Bronchodilation begins within 1–5 minutes, peaks at 30–90 minutes, and lasts 4–6 uur. levosalbutamol also modestly inhibits mast-cell mediator release, reduces plasma exudation from airway capillaries, and improves mucociliary clearance.

Selectivity is dose-dependent: at therapeutic doses, β2 effects predominate; at higher systemic doses (oral tablets, repeated nebulisation), spillover onto β1 receptors causes tachycardia and palpitations, and onto β2 receptors elsewhere causes tremor and hypokalaemia.

Toepassingen en Indicaties

• Acute asthma exacerbations — first-line reliever (rescue) inhaler/nebulisation
• Chronic obstructive pulmonary disease (COPD) — symptomatic relief of acute breathlessness and exercise dyspnoea
• Exercise-induced bronchoconstriction — inhaled 15–30 minutes before exercise
• Bronchospasm with allergen, cold air, or viral exposure
• Anaphylaxis with bronchospasm — adjunct to adrenaline
• Hyperkaliëmie (off-label) — nebulised salbutamol drives K⁺ intracellularly

Belangrijk: Levolin Inhaler is a reliever, not a controller. It does not reduce underlying airway inflammation. Patients using more than the equivalent of one SABA canister per month, or needing a SABA more than three days per week outside of exercise pre-dosing, have poorly-controlled asthma and require step-up to inhaled corticosteroid (ICS) or ICS-LABA combination therapy.

Levolin Inhaler Dosage

How to Use Levolin Inhaler Properly

• Shake well; remove the cap.
• Breathe out fully away from the inhaler.
• Seal lips around the mouthpiece.
• Press the canister as you start a slow deep breath (3–5 seconds).
• Hold breath 10 seconds, then breathe out through the nose.
• Wait 30 seconds before a second puff.
• Use a spacer for children, the elderly, or anyone with poor coordination.

Side Effects of Levolin Inhaler

Common (dose-related, settle within 30–60 minutes):

• Fine tremor, especially of the hands
• Palpitations or increased heart rate (typically 10–20 bpm rise)
• Hoofdpijn
• Dry mouth, throat irritation (more common with DPI/MDI)
• Muscle cramps
• Hyperactivity or agitation in young children

Minder vaak:

• Hypokalaemia — especially with high repeat doses, worsened by theophylline, steroids or loop diuretics
• Milde hyperglykemie
• Insomnia if dosed late evening
• Possible paradoxical worsening with the R-isomer is rare

Serious (stop and seek emergency help):

• Severe allergic reaction / angio-oedema / anaphylaxis
• Paradoxical bronchospasm — worsening wheeze immediately after dose
• Cardiac arrhythmias (atrial fibrillation, supraventricular tachycardia)
• Severe hypokalaemia with arrhythmia or muscle weakness

Waarschuwingen en voorzorgsmaatregelen

• Frequent {$brand} use = poor asthma control. Needing a reliever more than 3 days per week (excluding exercise pre-dosing) means the underlying disease is not managed. Step up ICS-based controller therapy.
• Carry your reliever with you — many fatal asthma attacks happen when the inhaler is at home or expired.
• Cardiovascular disease: use cautiously in severe coronary artery disease, arrhythmias, hyperthyroidism, or severe heart failure.
• Diabetes: monitor glucose with repeat high doses.
• Zwangerschap en borstvoeding: levosalbutamol is used at the lowest effective dose. Uncontrolled asthma is more dangerous to mother and fetus than the drug itself.
• Severe attack red flags (call emergency services): no relief 10 min after a full dose, peak flow <50% of personal best, difficulty speaking in full sentences, blue lips or drowsiness.

Contra-indicaties

• Known hypersensitivity to levosalbutamol or any formulation excipient
• Tachyarrhythmias (uncontrolled) — relative contraindication
• Phaeochromocytoma — relative contraindication
• Hypertrophic obstructive cardiomyopathy — caution

Geneesmiddelinteracties

Opslag

• Store below 25°C, protected from direct sunlight and heat.
• Do not refrigerate. Do not freeze.
• Do not puncture the canister; even an empty canister can explode if heated.
• Keep out of reach of children. Use within the expiry date printed on the canister.

Gerelateerde alternatieven op MedsBase

• Asthalin Respules — salbutamol nebuliser solution
• Budecort Inhaler — budesonide ICS preventer
• Foracort Inhaler — budesonide + formoterol ICS-LABA
• Seretide Accuhaler — fluticasone + salmeterol ICS-LABA
• Duolin Inhaler — salbutamol + ipratropium combo reliever

Veelgestelde vragen

How is Levolin Inhaler different from Asthalin Inhaler?

Asthalin = salbutamol 100 mcg per puff (racemic mixture). Levolin = levosalbutamol 50 mcg per puff (active R-isomer only). Clinically equivalent at half the milligram dose. Some patients report less tremor and palpitations on Levolin.

How many puffs of Levolin can I take?

Routine: 1–2 puffs every 4–6 hours, max 8 puffs (400 mcg) per day. Severe attack: 4–10 puffs via spacer under supervision.

Can children use Levolin Inhaler?

Yes, from age 4–6 with a spacer + mask, or from age 6 with a spacer + mouthpiece.

Is Levolin Inhaler safer than Asthalin Inhaler?

In some patient groups (children, those with cardiac comorbidities, those who report tremor on salbutamol), levosalbutamol may have a marginally better tolerability profile. For most adults the difference is small.

Should I use a spacer?

A spacer is strongly recommended for children, the elderly, anyone with arthritis or coordination problems, and in any acute attack. It improves drug delivery 2–3× and removes the need to time breath with actuation.

How fast should I inhale?

Slow and deep over 3–5 seconds (this is the MDI rule — opposite of DPI rotacaps which need a fast inhalation).

Why is my mouth dry?

Local deposition on the oropharynx is normal. A spacer reduces it. Rinsing mouth after use helps.

Can I take Levolin Inhaler with a beta-blocker?

Cardioselective beta-blockers (bisoprolol, atenolol) are usually OK; non-selective (propranolol) and timolol eye drops should be avoided where possible.

How long does the canister last?

A 200-puff canister lasts about 100 days at 2 puffs/day. Track usage or check the dose counter if fitted.

Gerelateerde alternatieven

Andere producten in Chronische aandoeningen die klanten ook bekijken:

• Frusenex
• Lonitab
• Leemigran
• Kenacort
• Cytomid

More options in Asthma/COPD Treatment

Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.

Asthalin

US$2.00 – US$8.00Zakres cen: US$2.00 do US$8.00

Aerocort Inhaler

US$6.00 – US$14.00Zakres cen: US$6.00 do US$14.00

Asthalin Respules

US$10.90 – US$27.50Zakres cen: US$10.90 do US$27.50