Pirox DT
✅ Pain relief
✅ Reduced inflammation
✅ Improved joint mobility
✅ Muscle relaxation
✅ Easy dosage
Pirox DT contains Piroxicam.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Pirox DT?
Pirox DT is een piroxicam 20 mg dispersible tablet. Piroxicam is a long-acting non-selective NSAID with a ~50-hour plasma half-life that allows simple once-daily dosing. Because of its long duration and higher GI and skin-reaction profile compared to newer NSAIDs, piroxicam is reserved for second-line use in osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis when other NSAIDs are not tolerated or effective. Usual dose: one 20 mg dispersible tablet once daily with food.
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Pirox DT is an oral dispersible tablet of piroxicam 20 mg, a long-established non-selective NSAID from the oxicam class. The “DT” designation means the tablet disperses in water to form a milky suspension that is easy to swallow — useful for elderly patients, children, and anyone with swallowing difficulty.
Piroxicam’s outstanding feature is its very long plasma half-life of approximately 50 hours, which allows once-daily dosing and steady 24-hour anti-inflammatory cover. This makes adherence easy in chronic inflammatory conditions. The trade-off is that once-daily exposure is prolonged, and the GI and cutaneous adverse-event rate is higher than newer, shorter-acting NSAIDs. Regulators in the EU and several Asian markets have therefore restricted piroxicam to second-line use under specialist supervision, usually when first-line NSAIDs have failed or caused problems.
What Is Pirox DT Used For?
- Osteoarthritis — symptomatic relief of pain and stiffness (second-line)
- Rheumatoid arthritis — second-line anti-inflammatory
- Ankylosing spondylitis — chronic inflammatory back pain
- Acute gout — 40 mg loading dose (two tablets) then 20 mg/day for 4–6 days
- Primary dysmenorrhoea (short course)
- Post-operative pain in selected patients where once-daily dosing simplifies care
How Does Piroxicam Work?
Piroxicam is a non-selective NSAID — it blocks both COX-1 (which maintains stomach lining, platelet function, and kidney perfusion) and COX-2 (which is upregulated at sites of inflammation). This broad action explains both its strong anti-inflammatory effect and its well-known gastrointestinal and renal side-effect profile.
The therapeutic chain of events is the same for every NSAID:
- Tissue injury or inflammation releases phospholipids from cell membranes
- Phospholipase A₂ converts them to arachidonic acid
- Cyclooxygenase (COX-1/COX-2) converts arachidonic acid to prostaglandins — the molecules responsible for pain, swelling, and fever
- Piroxicam blocks the COX enzymes, so less prostaglandin is produced, so there is less pain and inflammation
Because prostaglandins also protect the stomach lining, regulate kidney blood flow, and influence platelet function, the same mechanism that relieves pain is also responsible for the main NSAID side effects: stomach irritation, fluid retention, high blood pressure, and (in some individuals) kidney stress.
Pirox DT Dosing
- Chronic inflammatory arthritis: 20 mg once daily with food
- Acute gout: 40 mg on day 1 (as a single dose or split AM/PM), then 20 mg once daily for 4–6 days, then stop
- Elderly, low body weight: consider alternative NSAIDs; if piroxicam is used, keep at 10 mg once daily (requires compounded form or half tablet under medical supervision)
To use Pirox DT: drop one tablet into a small glass of water, allow it to disperse (about 1 minute), stir, and drink. Take immediately after food. Do not chew or swallow the tablet whole for rapid effect — disperse as directed.
Because piroxicam has a half-life of ~50 hours, steady-state plasma levels take 7–10 days to build up — this is why the full clinical effect in arthritis may not appear for 1–2 weeks. Conversely, if the drug is stopped, effects taper over a similar time.
GI safety — read this before the first dose. Every NSAID, including Pirox DT, carries a real risk of gastritis, peptic ulcer, and upper-GI bleeding. The risk is highest in patients over 65, in those with prior ulcer disease, and in anyone also taking low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Pirox DT met voedsel, use the lowest effective dose for the shortest reasonable time, and ask your doctor about co-prescribing a proton pump inhibitor (omeprazole, pantoprazole) if you need it for more than 2–4 weeks.
Piroxicam-specific note: Among NSAIDs, piroxicam has one of the higher rates of severe skin reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis). Stop the drug and seek urgent care if you develop a widespread rash, blistering, mouth sores, or peeling skin.
Who Should Not Take Pirox DT?
- Known hypersensitivity to Piroxicam or any NSAID
- Active or recurrent peptic ulcer, GI bleed, or GI perforation
- Asthma, urticaria, or rhinitis precipitated by aspirin or another NSAID (“aspirin-exacerbated respiratory disease”)
- Severe heart failure (NYHA class IV)
- Severe hepatic impairment (Child–Pugh C)
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy (risk of premature ductus arteriosus closure and oligohydramnios)
- Recent coronary artery bypass graft surgery (CABG) — absolute contraindication for all NSAIDs
Cardiovasculair risico
All NSAIDs (except low-dose aspirin) carry some increase in the risk of heart attack and stroke, and can worsen heart failure. The risk is dose- and duration-dependent and is generally highest with COX-2 selective agents and with diclofenac. Patients with established ischaemic heart disease, peripheral arterial disease, stroke, or uncontrolled hypertension should use non-selective NSAIDs (ibuprofen or naproxen) at the lowest effective dose, or use paracetamol instead where possible.
Renal (kidney) safety
NSAIDs reduce renal prostaglandin production, which can cause salt and water retention, raise blood pressure, and — in vulnerable patients — cause acute kidney injury. High-risk groups are the elderly, patients on ACE inhibitors/ARBs plus diuretics (the “triple whammy”), anyone dehydrated (vomiting, diarrhoea, heat, heavy exercise), and those with pre-existing CKD. Stop the NSAID and seek medical review if you develop reduced urine output, swelling, or unexplained weight gain.
Side Effects of Pirox DT
- Vaak voorkomend: dyspepsia, nausea, abdominal pain, diarrhoea, headache, dizziness, fluid retention
- Minder vaak voorkomend: peptic ulcer, GI bleeding, elevated liver enzymes, tinnitus, palpitations
- Zeldzaam maar ernstig: severe skin reactions (Stevens-Johnson syndrome, TEN), severe hepatotoxicity, acute kidney injury, bone-marrow suppression, anaphylaxis
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Medisch disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. NSAIDs have well-documented gastrointestinal, cardiovascular, and renal risks — please talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, or are pregnant.
Veelgestelde vragen
What is Pirox DT used for?
Pirox DT (piroxicam 20 mg dispersible) is used for chronic inflammatory arthritis — osteoarthritis, rheumatoid arthritis, ankylosing spondylitis — and for acute gout. It is usually a second-line NSAID.
How does dispersible piroxicam compare to regular tablets?
The active drug and dose are identical. The dispersible form (DT) is easier to swallow and slightly faster to absorb, making it useful for elderly patients or those with swallowing difficulty.
Why is piroxicam considered second-line?
European regulators restricted first-line use of piroxicam in 2007 because of higher GI and serious skin-reaction rates compared to newer NSAIDs. It is still useful when a long half-life and once-daily dosing are particularly helpful.
How long does Pirox DT take to work?
Symptom relief usually starts within 2–4 hours of the first dose. Full anti-inflammatory effect builds over 1–2 weeks because of the long half-life and gradual plasma accumulation.
Can I take Pirox DT with food?
Always take with or immediately after food. This substantially reduces gastric irritation.
Is Pirox DT safe long-term?
For chronic arthritis it can be used long-term with specialist supervision, a proton pump inhibitor for GI protection, and regular review of blood pressure, kidney function, liver enzymes, and skin.
Can I take Pirox DT for a headache?
For simple headaches or mild pain, piroxicam is rarely the right choice — its 50-hour half-life means exposure persists for days after a single dose. Ibuprofen or paracetamol is usually preferable.
What should I do if I develop a rash while taking Pirox DT?
Stop the tablet and contact your doctor the same day. If there is blistering, mouth sores, peeling skin, or fever, attend A&E — this may be a severe cutaneous reaction.
Can I drink alcohol on Pirox DT?
Avoid alcohol while on piroxicam — the combination greatly raises GI bleed risk.
Is Pirox DT safe in pregnancy?
No — avoid from 20 weeks onward and contraindicated in the third trimester. Use in early pregnancy only under specialist advice.
What if I miss a dose of Pirox DT?
Take it when you remember, unless it is close to the next day’s dose — then just take the next scheduled dose. Because piroxicam accumulates slowly, a missed day has minimal immediate impact; never take a double dose to catch up.
Patients stabilised on Pirox DT (piroxicam 20 mg) for chronic musculoskeletal pain sometimes add Emanzen Forte (serratiopeptidase 10 mg) to address residual oedema through the proteolytic enzyme’s fibrinolytic and tissue-drainage action, which NSAIDs do not directly provide.
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| Sterkte | 20 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Pirox DT
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