Decdan
✅ Reduces inflammation & swelling
✅ Manages allergic reactions
✅ Relieves pain and discomfort
✅ Treats skin conditions
✅ Improves breathing
Decdan contains Dexamethasone.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Decdan?
Decdan is een dexamethasone 0.5 mg oral tablet — a potent long-acting synthetic corticosteroid used for a wide range of inflammatory, allergic, autoimmune, and malignant conditions. It is clinically equivalent to Dexona 0.5 mg and Decmax 4 mg (same molecule at different strengths). Typical daily dose is 0.75–9 mg depending on indication, always taken with food, preferably in the morning. Never stop Decdan abruptly after a prolonged course.
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Decdan 0.5 mg is een orale tablet van dexamethasone, manufactured by Cadila. Dexamethasone is one of the most potent synthetic glucocorticoids in routine clinical use — approximately 25–30 times more active per milligram than hydrocortisone, with no mineralocorticoid effect and a long biological half-life.
Decdan 0.5 mg is typically used for:
- Maintenance and low-dose immunosuppressive therapy in chronic autoimmune disease
- Fine dose-titration during tapering of higher-dose steroid courses
- Paediatric dosing, where 0.5 mg tablets can be broken or combined for weight-based doses
- Diagnostic dexamethasone suppression test (low-dose protocol uses 1 mg at 11 pm — two 0.5 mg tablets)
What Is Decdan Used For?
- Inflammatory and allergic conditions — severe eczema flare, allergic rhinitis, drug reactions
- Autoimmune disease — rheumatoid arthritis, SLE, polymyalgia rheumatica, vasculitis, inflammatory bowel disease
- Asthma and COPD exacerbations (short courses)
- Cerebral oedema (higher doses — 4–16 mg/day, usually via Decmax 4 mg)
- Anti-emetic cover during chemotherapy
- Severe COVID-19 requiring oxygen (6 mg/day x 10 days)
- Croup in children (weight-based single dose)
- Adrenal hyperplasia (congenital adrenal hyperplasia — specialist endocrinology dose)
- Bacterial meningitis (adjunct for neurological protection)
- Dexamethasone suppression test for Cushing syndrome
Decdan Dosing
- Low-dose maintenance: 0.5–1 mg daily (1–2 tablets)
- Mild to moderate inflammatory indications: 0.75–3 mg/day
- Moderate indications: 4–6 mg/day (usually via Decmax 4 mg)
- Severe conditions, cerebral oedema: 4–16 mg/day (Decmax 4 mg)
- Overnight suppression test: 1 mg at 11 pm, cortisol drawn the following morning
- — verbetert de verdraagzaamheid van metformine., preferably morning
Corticosteroid Potency and Equivalence
Different corticosteroids differ mainly in potency, duration of action, and mineralocorticoid (salt-retaining) activity. The table below gives the clinically useful equivalence — it lets you translate a dose of one steroid into the equivalent dose of another.
| Corticosteroid | Glucocorticoid potency | Equivalent dose | Mineralocorticoid | Duur |
|---|---|---|---|---|
| Hydrocortisone | 1 (reference) | 20 mg | Substantial | 8–12 h |
| Prednisolone | 4 | 5 mg | Low | 12–36 h |
| Methylprednisolone | 5 | 4 mg | Minimaal | 12–36 h |
| Dexamethasone | 25–30 | 0.75 mg | None | 36–54 h |
| Betamethasone | 25–30 | 0.75 mg | None | 36–54 h |
Who Should Not Take Decdan?
- Systemic fungal infection (other than as replacement therapy in adrenal insufficiency)
- Live vaccines during immunosuppressive doses (see specialist before BCG, MMR, yellow fever, varicella, oral typhoid)
- Active untreated bacterial infection (start antibiotics first)
- Active tuberculosis without anti-TB cover
- Known hypersensitivity to the active molecule or any excipient
- Use with caution in: diabetes mellitus, congestive heart failure, hypertension, osteoporosis, peptic ulcer, psychiatric disorders, glaucoma, herpes simplex ophthalmicus
- Pregnancy: use only if clearly needed — prednisolone and hydrocortisone cross the placenta less than dexamethasone/betamethasone, which are preferred when a fetal effect is intended (e.g. lung maturation)
Side Effects of Corticosteroids
Corticosteroid side effects are dose- and duration-dependent. Short courses (< 2 weeks) at moderate doses are usually well tolerated. Longer or higher-dose therapy produces the classic “Cushingoid” profile.
Short-term (first 1–2 weeks):
- Insomnia, anxiety, euphoria, irritability — particularly at doses > 20 mg prednisolone-equivalent
- Increased appetite, weight gain
- Raised blood glucose (especially in diabetes)
- Fluid retention, mild ankle swelling
- Heartburn, dyspepsia
- Hypertension — especially with higher mineralocorticoid activity (hydrocortisone, fludrocortisone)
Longer-term (weeks to months):
- Osteoporosis and vertebral fractures
- Muscle wasting and proximal myopathy
- Skin thinning, easy bruising, striae, impaired wound healing
- Cushingoid appearance — moon face, central obesity, buffalo hump
- Cataracts, glaucoma
- Infection susceptibility (bacterial, viral, fungal, parasitic)
- Avascular necrosis of the femoral head
- HPA-axis suppression — risk of adrenal crisis on abrupt withdrawal
- Psychiatric effects — depression, mania, psychosis
- Peptic ulcer, especially when combined with NSAIDs
Zeldzaam maar ernstig: steroid psychosis, pancreatitis, posterior subcapsular cataract, severe osteonecrosis.
Never stop corticosteroids abruptly after a prolonged course. Any course longer than 2–3 weeks, or any dose above a physiological replacement level (approximately 7.5 mg prednisolone or 40 mg hydrocortisone per day) suppresses the hypothalamic-pituitary-adrenal axis. Stopping suddenly can trigger a life-threatening adrenal crisis — nausea, vomiting, low blood pressure, shock. Courses longer than 3 weeks must be tapered down, typically over 1–4 weeks depending on duration and dose. Carry a steroid warning card during prolonged treatment and inform any doctor, dentist, or surgeon you see about your steroid use.
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Medisch disclaimer. De informatie op deze pagina is alleen bedoeld voor algemene educatie. Het is geen vervanging voor advies van uw eigen arts of apotheker. Overleg met een gekwalificeerde zorgprofessional voordat u een therapie start, stopt of wijzigt.
Veelgestelde vragen
What is Decdan used for?
Decdan (dexamethasone 0.5 mg) is used for inflammatory, allergic, autoimmune, and malignant conditions. At 0.5 mg strength it is particularly useful for low-dose maintenance, dose tapering, paediatric weight-based dosing, and the overnight dexamethasone suppression test.
Is Decdan the same as Dexona?
Yes. Both are dexamethasone 0.5 mg tablets. Decdan is a Cadila brand; Dexona is a Zydus Cadila brand. Clinically equivalent.
Is Decdan the same as Decmax?
Same molecule (dexamethasone) but different strength. Decdan is 0.5 mg; Decmax is 4 mg. Higher-strength Decmax is used for acute inflammatory conditions, cerebral oedema, and anti-emetic cover in chemotherapy.
How long does Decdan take to work?
Oral dexamethasone reaches peak plasma level in 1–2 hours. Because of the long half-life (36–54 hours), a single dose continues to act for up to 2 days.
Why is dexamethasone used in the overnight suppression test?
Because of its long half-life and strong negative-feedback effect on the HPA axis. A 1 mg dose at 11 pm suppresses next-morning cortisol in healthy people; failure of suppression suggests Cushing syndrome.
Can I take Decdan long-term?
Long-term dexamethasone is generally avoided where possible because of its strong HPA suppression. When chronic low-dose steroid therapy is needed (e.g. maintenance in inflammatory disease), prednisolone is usually preferred. Consult your specialist.
Can I stop Decdan suddenly?
Short courses under 2 weeks can usually be stopped without tapering. Longer courses need a formal taper to avoid adrenal crisis.
Is Decdan safe in pregnancy?
Dexamethasone crosses the placenta readily and is used antenatally to promote fetal lung maturation. For maternal disease, prednisolone is usually preferred unless dexamethasone is specifically indicated.
Can Decdan be used in children?
Yes, particularly for croup and as part of paediatric chemotherapy protocols. Dosing is weight-based under paediatric supervision.
Does Decdan raise blood sugar?
Yes — dexamethasone raises blood glucose. Diabetic patients need closer monitoring and possibly dose adjustment of insulin or oral hypoglycaemics during therapy.
What if I miss a dose of Decdan?
Take it when you remember unless the next scheduled dose is due within 12 hours — then skip. Never double up.
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| Sterkte | 0.5 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
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