Flexabenz
✅ Relieves muscle spasms
✅ Reduces muscle tension
✅ Alleviates pain
✅ Enhances flexibility
✅ Verbeterd mobiliteit
Flexabenz contains Cyclobenzaprime.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Flexabenz?
Flexabenz is een cyclobenzaprine 5 mg tablet (immediate release), a centrally-acting muscle relaxant used as a short-course adjunct for acute painful musculoskeletal spasm. Usual adult dose is 5 mg three times daily (may be increased to 10 mg three times daily if tolerated) for 2 to 3 weeks maximum. Cyclobenzaprine is structurally related to tricyclic antidepressants and is one of the more sedating muscle relaxants — it is often taken at bedtime where drowsiness is a useful side effect.
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Flexabenz 5 mg is an oral tablet form of cyclobenzaprine, the most widely prescribed centrally-acting muscle relaxant in the United States. Cyclobenzaprine is structurally related to the tricyclic antidepressants (amitriptyline, nortriptyline), but it does not have meaningful antidepressant activity at muscle-relaxant doses.
Flexabenz is the 5 mg “starter” and usual-dose tablet. A 10 mg tablet is also available for patients who need more effect and tolerate the 5 mg dose well. For chronic or long-acting dosing, the 15 mg extended-release formulation (Flexabenz ER) is often preferred because it allows once-daily dosing with a smoother plasma profile.
What Is Flexabenz Used For?
- Acute low back pain with muscle spasm
- Acute neck pain and torticollis
- Muscle strain — hamstring, calf, shoulder, paraspinal muscles
- Post-traumatic muscle spasm (whiplash, soft-tissue injury)
- Myofascial pain syndrome — adjunct
- Fibromyalgia-associated muscle pain and sleep disturbance (off-label; often at bedtime)
- Tension headache with prominent cervical muscle component (short course)
Flexabenz is niet indicated for spasticity due to upper motor neuron disease (cerebral palsy, spinal cord injury, multiple sclerosis). For those conditions, baclofen or tizanidine are preferred.
How Does Cyclobenzaprine Work?
Cyclobenzaprine reduces tonic somatic motor activity by acting on the brainstem — particularly at the locus coeruleus — rather than at the spinal cord or muscle itself. It modulates descending serotonergic and noradrenergic pathways, decreasing the excitatory drive to muscle spindles and reducing the involuntary tonic muscle contraction that follows painful musculoskeletal injury.
Flexabenz Dosing
- Startdosis: 5 mg three times daily; may increase to 10 mg TID if needed and tolerated
- Maximum: 30 mg per day in divided doses (rarely needed)
- Duration: up to 2–3 weeks. Not intended for long-term use.
- Elderly patients: start at 5 mg at bedtime; titrate slowly; anticholinergic effects are more prominent
- Mild hepatic impairment: reduce dose or use less frequently
- Moderate/severe hepatic impairment: vermijden
Many patients take the largest dose at bedtime to make use of the drowsiness for sleep.
Driving and CNS safety for Flexabenz. Centrally-acting muscle relaxants cause drowsiness, dizziness, and slowed reaction time — especially in the first few days of treatment. Do not drive, operate machinery, or make safety-critical decisions until you know how you react to this medicine. The effect is stronger with alcohol, opioid pain medication, sleeping tablets, or anti-anxiety medication — avoid these combinations unless your doctor has cleared them. Muscle relaxants are short-course medicines — typically used for 1–3 weeks at the start of a musculoskeletal injury while physiotherapy and exercise do the longer-term work.
Who Should Not Take Flexabenz?
- Known hypersensitivity to cyclobenzaprine
- Concurrent use of a monoamine oxidase inhibitor (MAOI) or within 14 days of stopping one
- Acute recovery phase from myocardial infarction
- Heart block, arrhythmias, or conduction disturbances
- Congestive heart failure
- Hyperthyreoïdie
- Moderate or severe hepatic impairment
- Angle-closure glaucoma
- Urinary retention, benign prostatic hypertrophy with significant obstruction
- Narcotic-induced respiratory depression
Bijwerkingen
- Very common (> 10%): drowsiness, dry mouth, dizziness
- Common (1–10%): fatigue, headache, nausea, constipation, blurred vision, urinary retention, palpitations
- Minder vaak voorkomend: confusion (especially in elderly), elevated liver enzymes, skin rash
- Zeldzaam maar ernstig: serotonin syndrome (when combined with SSRIs, SNRIs, tramadol, MAOIs), hepatotoxicity, cardiac arrhythmias, anaphylaxis
Stop and seek urgent care if you develop chest pain, rapid heart rate, severe agitation or confusion, tremor, hyperreflexia, or fever (possible serotonin syndrome).
Key Drug Interactions
- MAOIs — absolute contraindication (risk of hyperpyrexia, seizures)
- SSRIs, SNRIs, tramadol, triptans — serotonin syndrome risk
- Alcohol, opioids, benzodiazepines, sleeping tablets — additive CNS depression
- Anticholinergic drugs (hyoscine, tricyclic antidepressants, some antihistamines) — additive anticholinergic effects
- CYP1A2/CYP3A4 inhibitors (ciprofloxacin, fluvoxamine) — may raise cyclobenzaprine levels
Bestellen & Levering
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Medisch disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, liver disease, or are pregnant.
Veelgestelde vragen
What is Flexabenz used for?
Flexabenz (cyclobenzaprine 5 mg) is used for acute muscle spasm associated with musculoskeletal conditions — low back pain, neck strain, torticollis, and muscle injuries. It is a short-course medication.
Does Flexabenz make you sleepy?
Yes. Drowsiness affects more than 1 in 3 users and is the most common side effect. Many patients take the largest dose at bedtime to use the drowsiness for sleep. Do not drive until you know how it affects you.
How long can I take Flexabenz?
Up to 2 to 3 weeks. Cyclobenzaprine is not intended for long-term use. If pain persists beyond 3 weeks, the underlying cause needs reassessment.
Is Flexabenz addictive?
Cyclobenzaprine is not classified as a controlled substance in most jurisdictions and is not considered to cause meaningful physical dependence. Psychological misuse does occur, particularly in combination with opioids — use as prescribed.
Can I take Flexabenz with ibuprofen, paracetamol, or diclofenac?
Yes — these combinations are standard for acute musculoskeletal pain and work on complementary mechanisms.
Can I take Flexabenz with sertraline, fluoxetine, or another SSRI?
Caution is needed — the combination raises the risk of serotonin syndrome. Discuss with your doctor before starting. If used together, watch for agitation, confusion, shivering, diarrhoea, rapid heart rate, and fever — seek urgent care if these occur.
Can I take Flexabenz with tramadol?
Avoid if possible — both drugs increase serotonin availability and together they raise serotonin-syndrome risk. If both are required, close supervision is needed.
Can I drink alcohol while on Flexabenz?
Avoid alcohol. The combination greatly increases drowsiness, dizziness, and fall risk.
Is Flexabenz safe in pregnancy?
Data are limited. Avoid in the first trimester unless clearly needed; use in pregnancy should be only on specialist advice.
What is the difference between Flexabenz and Flexabenz ER?
Both contain cyclobenzaprine. Flexabenz is 5 mg immediate release, dosed 3 times daily. Flexabenz ER is 15 mg extended release, dosed once daily — smoother plasma profile and simpler adherence.
Can I stop Flexabenz suddenly?
After short courses (2–3 weeks), yes — no taper needed. Long-term use (> 4 weeks) can rarely produce mild rebound symptoms; taper over a few days if you have been on high-dose therapy for longer than label recommends.
Patients on cyclobenzaprine who experience excessive sedation or anticholinergic side effects can switch to Synaptol (tolperisone 150 mg) — a centrally-acting muscle relaxant with a much cleaner side-effect profile and no anticholinergic burden.
Zie ook: this tolperisone brand — tolperisone alternative when cyclobenzaprine sedation is unacceptable — centrally acting without H1 antihistamine drowsiness.
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| Sterkte | 5 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Flexabenz
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Flexabenz
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