Urispas

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What is Urispas?

Urispas is a brand of flavoxate hydrochloride 200 mg tablets manufactured for relief of urinary tract spasm and discomfort. Flavoxate has been in clinical use since the 1960s and remains widely prescribed in India, parts of Asia, and South America for symptomatic relief of urinary symptoms. International equivalents include Bladderon and Genurin. Pack sizes available at MedsBase: 30, 60, 90 or 180 tablets.

How flavoxate works

Flavoxate has a multi-component mechanism that distinguishes it from pure anticholinergic OAB drugs:

• Direct smooth-muscle relaxation — via inhibition of phosphodiesterase and calcium influx in detrusor smooth muscle. This is the dominant mechanism.
• Weak anticholinergic effect — mild competitive inhibition at muscarinic receptors
• Mild local analgesic effect — reduces sensory urgency from inflamed bladder mucosa

The combination makes flavoxate particularly useful for the burning, frequency, and spasm of acute infectious cystitis, urethritis, or post-procedural irritation — where you want symptomatic relief while the underlying infection or healing is addressed. It is generally less effective than dedicated OAB drugs for chronic detrusor overactivity.

When flavoxate is used

• Symptomatic relief of cystitis (acute infectious cystitis with antibiotics; interstitial cystitis adjunct)
• Urethritis, urethrocystitis, urethrotrigonitis
• Prostatitis — for the urinary urgency and frequency component
• Post-cystoscopy or post-prostatectomy urinary discomfort
• Post-catheterisation bladder spasm — relieves the painful spasms associated with indwelling catheters
• Suprapubic pain, urgency, frequency, dysuria, nocturia from any benign cause
• Adjunct to antibiotics in UTI for symptomatic relief while the antibiotic addresses the infection

Flavoxate is NOT a treatment for urinary tract infection (it has no antibacterial activity) — if you have a UTI, you also need an appropriate antibiotic (nitrofurantoin, fosfomycin, trimethoprim-sulfamethoxazole, ciprofloxacin, depending on culture). Flavoxate provides symptom relief in parallel.

Dosering & hoe in te nemen

• Standard adult dose: 200 mg three or four times daily (600-800 mg per day)
• Take with food and a glass of water; food reduces gastrointestinal side effects
• Onset of symptom relief is usually within 1-3 hours; full effect over a few days
• Treatment is typically short-term (a few days to 2 weeks) for an acute episode of cystitis or post-procedural symptom relief; longer use is appropriate for chronic conditions only under medical supervision
• Children <12: not recommended (lack of paediatric data)
• Ouderen: standard dosing — flavoxate has milder anticholinergic activity than oxybutynin/tolterodine and is generally well-tolerated in older adults, though the same caution applies if multiple anticholinergics are stacked
• Renal/hepatic impairment: use with caution; reduce dose if severe

Bijwerkingen & veiligheid

• Vaak (1 op de 10): nausea, vomiting, dry mouth (mild), drowsiness, headache, dizziness, blurred vision
• Minder vaak: palpitations, tachycardia, urinary retention or hesitancy, constipation, fatigue, mental confusion (especially elderly with high doses)
• Zeldzaam: rash, urticaria, allergic reactions, eosinophilia, leucopenia, hepatic enzyme elevation
• Very rare: increased intraocular pressure (caution if narrow-angle glaucoma)

Contra-indicaties & waarschuwingen

Do not take flavoxate if you have:

• Pyloric or duodenal obstruction
• Obstructive intestinal lesion or ileus
• Achalasia
• GI haemorrhage
• Obstructive uropathy (lower urinary tract obstruction)
• Hypersensitivity to flavoxate

Wees voorzichtig bij: narrow-angle glaucoma, benign prostatic hyperplasia (urinary retention risk), elderly age (cognitive effects with high doses), pregnancy and breastfeeding (limited data; use only if benefit outweighs risk).

Geneesmiddelinteracties

• Other anticholinergics (oxybutynin, tolterodine, hyoscyamine, scopolamine, diphenhydramine, amitriptyline) — additive effects; minimise stacking
• CNS depressants (alcohol, benzodiazepines, opioids) — additive sedation
• Cholinesterase inhibitors (donepezil, rivastigmine for dementia) — opposing mechanisms

How flavoxate compares

Flavoxate occupies a niche distinct from the dedicated OAB drugs:

• Flavoxate (Urispas) — mild, broad-spectrum urinary antispasmodic; best for short-term symptomatic relief of UTI/post-procedure spasm
• Oxybutynin (Oxyspas) — classic anticholinergic OAB drug; more potent, more side effects, better for chronic OAB
• Tolterodine IR (Roliten) / Tolterodine LA (Terol LA) — better-tolerated anticholinergic OAB drug; LA form once-daily
• Mirabegron (Mirago) — β3 agonist with no anticholinergic burden; preferred first-line for chronic OAB in older adults

For an acute UTI, the right combination is usually antibiotic + flavoxate for symptom relief (not flavoxate alone). For chronic OAB, dedicated OAB drugs (mirabegron or anticholinergics) are typically more effective long-term.

Opslag & houdbaarheid

Store Urispas tablets below 25°C in the original blister pack. Protect from moisture and light. Keep out of reach of children. Do not use after the expiry date.

Veelgestelde vragen

How quickly does Urispas relieve urinary spasm?

Symptomatic relief is typically noticeable within 1-3 hours of the first dose, with steadier relief over the first 1-2 days of regular dosing. For an acute UTI, you should be feeling better symptomatically within 24-48 hours of starting both the antibiotic and flavoxate.

Is flavoxate an antibiotic?

No — flavoxate has no antibacterial activity. It relieves the urinary spasm and burning that accompany cystitis but does not treat the infection itself. If you have a UTI you also need an appropriate antibiotic (nitrofurantoin, fosfomycin, trimethoprim, or based on urine culture) and flavoxate is the symptom-relief adjunct.

Can flavoxate replace oxybutynin or tolterodine for OAB?

For mild OAB symptoms, flavoxate may provide adequate relief and is gentler than oxybutynin/tolterodine. For moderate-to-severe OAB symptoms, the dedicated OAB drugs are typically more effective — mirabegron is preferred first-line, especially in older adults; tolterodine LA is the better-tolerated anticholinergic option.

Is Urispas safe in pregnancy?

Limited human pregnancy data — use only if benefit clearly outweighs risk. For UTI in pregnancy, the principal management is appropriate antibiotic; flavoxate is generally avoided in the first trimester unless symptoms are severe.

Why do I feel drowsy after taking it?

Mild central anticholinergic activity contributes to drowsiness in some patients, especially at the four-times-daily dose. Avoid driving or operating machinery until you know how flavoxate affects you. Effects usually settle within a few days.

How long can I stay on flavoxate?

Flavoxate is typically prescribed for short courses (a few days to 2-3 weeks) to cover an acute episode of cystitis, post-procedural irritation, or a flare of interstitial cystitis. Longer use is appropriate for chronic conditions only under medical supervision. If you find you need flavoxate continuously for more than a few weeks, ask your doctor about evaluation for the underlying condition and switching to a dedicated OAB drug.

Can I take flavoxate with antibiotics?

Yes — flavoxate has no significant interaction with the antibiotics used for UTI (nitrofurantoin, fosfomycin, trimethoprim-sulfamethoxazole, ciprofloxacin, cephalosporins). The combination is the standard approach for symptomatic UTI — antibiotic to clear the infection, flavoxate for symptom relief during the first 24-72 hours.

Where can I order Urispas online?

You can order Urispas 200 mg tablets from MedsBase in pack sizes of 30 to 180 tablets. Orders ship worldwide with discreet packaging. Flavoxate is specialist-supervised in many countries.

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