Mebex

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What is Mebex?

Mebex is mebendazole 100 mg chewable from Cipla. Mebendazole was the first benzimidazole anthelmintic in routine human use and remains a WHO Essential Medicine. Albendazole has overtaken it as first-line in most settings, but mebendazole has a niche role: it is preferred in patients with concurrent moderate-to-severe hepatic impairment (less hepatic metabolism) and is the agent of choice in some paediatric whipworm protocols.

Mechanism of action

Mebendazole binds β-tubulin in parasite cells, preventing microtubule polymerisation. This blocks parasite glucose uptake and depletes glycogen stores — the worm starves over 2–3 days. Mebendazole’s oral bioavailability is very low (< 10%), which is therapeutically useful: high concentrations stay in the gut lumen where intestinal worms live, with minimal systemic exposure.

Mebex indications and dose

Tablets can be chewed, swallowed whole, or crushed and mixed with food.

Side effects

• Common: mild abdominal pain, transient diarrhoea, flatulence as worms pass
• Less common: headache, dizziness, mild rash
• Rare: reversible neutropenia (high-dose long courses), elevated transaminases, alopecia (very rare)
• Very rare: Stevens-Johnson syndrome, toxic epidermal necrolysis

Drug interactions

• Cimetidine — raises mebendazole plasma levels modestly; clinically relevant only in long courses for tissue parasites
• Phenytoin, carbamazepine, rifampicin — reduce mebendazole levels (CYP induction)
• Metronidazole — case reports of Stevens-Johnson syndrome with concurrent use; avoid if possible

Contraindications

• Hypersensitivity to mebendazole or other benzimidazoles
• Children < 1 year
• First trimester of pregnancy
• Severe hepatic impairment

Storage

Store Mebex below 30°C in the original blister, away from light and moisture.

Proč objednávat z MedsBase

Mebex is supplied from a WHO-GMP certified manufacturer, packaged discreetly, and shipped worldwide. Every order is covered by our Zárukou opětovného odeslání — you never wear the cost of a lost parcel.

Často kladené dotazy

Can I just take one tablet?

For pinworm, yes — one 100 mg dose, then a second at 2 weeks. For roundworm, hookworm, whipworm, or mixed infection, the standard course is 100 mg twice daily for 3 days.

Do I need to fast before Mebex?

No. Mebendazole works locally in the gut lumen and absorption is intentionally low. Take with or without food.

Can my child chew Mebex?

Yes — the tablet is designed to be chewed, swallowed whole, or crushed into food. Chewing is fine for children old enough to spit out anything they dislike (typically age 4+).

How is mebendazole different from albendazole?

Both are benzimidazoles with the same mechanism. Albendazole has higher systemic absorption (better for tissue-dwelling parasites like echinococcus), while mebendazole stays mostly in the gut lumen (preferred for some paediatric protocols and patients with hepatic impairment). For routine intestinal nematodes, both work.

Will Mebex treat tapeworm?

Mebendazole has activity against some intestinal cestodes (Hymenolepis nana) but is NOT first-line for tapeworm. Use niclosamide or praziquantel for confirmed Taenia infection.

How long until the worms are gone?

Adult worms are paralysed within 24–48 hours and pass in faeces over the following 3–5 days. Visible worms in stool are normal and a sign the drug is working. Itching and other symptoms resolve within 1–2 weeks.

Is Mebex safe in pregnancy?

Avoid in the first trimester. After week 13, mebendazole is acceptable for moderate-to-heavy worm burden — discuss with a clinician.

Can I drink alcohol with Mebex?

There is no specific alcohol interaction. Heavy alcohol use stresses the liver, and if the worm load is heavy enough to cause transient transaminase rise, abstaining for the treatment course is prudent.

Does Mebex treat lice or scabies?

No. Mebendazole has no activity against ectoparasites — use ivermectin or permethrin for scabies and pediculicide shampoos or oral ivermectin for lice.

Should I retest after treatment?

For routine pinworm or hookworm in an immunocompetent person with symptom resolution, no follow-up testing is needed. Persistent eosinophilia, weight loss, or recurring symptoms warrant repeat stool ova-and-parasite testing 2–4 weeks after treatment.

For broad-spectrum coverage beyond the standard mebendazole range offered by Mebex (mebendazole 100 mg), Wormentel (fenbendazole 222 / 500 mg) extends antiparasitic activity to Giardia, Trichinella, and tapeworm species not fully addressed by mebendazole monotherapy.

Other Antiparasitic Medications

• Mebex (mebendazole 100 mg)
• Lupimeb (mebendazole 100 mg)
• ABD 400 (albendazole 400 mg)
• Nemocid (pyrantel pamoate)
• Iverheal (ivermectin)

More options in Threadworm Treatment

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