Bulet SR
Bulet SR (Bupropion 150 mg SR) — NDRI antidepressant for major depression and smoking cessation. no sexual dysfunction, weight-neutral, activating.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Rychlá odpověď
Bulet SR (Bupropion 150 mg, sustained-release (SR)) is a dopamine-noradrenaline reuptake inhibitor (NDRI) used for major depression, smoking cessation (Zyban indication), and seasonal affective disorder. Distinct profile: stimulating rather than sedating, weight-neutral or weight-reducing, no sexual side effects. SR is dosed BID; XL is OD. Both share the same pharmacology and indications.
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Proč objednávat z MedsBase
Bulet SR at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Zárukou opětovného odeslání — 20pracovníchdenní lhůta pro doručení, nebo vám zásilku zdarma přepošleme — a opravňuje vás k účasti v našem věrnostním programu. Dodáváme do většiny zemí po celém světě.
What Bulet SR is and how it works
Bulet SR is a 150 mg bupropion sustained-release (SR) tablet supplied by Intas. Bupropion is the only widely-prescribed antidepressant whose primary action is dopamine-noradrenaline reuptake inhibition — not serotonin reuptake. This makes it pharmacologically distinct from SSRIs/SNRIs/TCAs and explains its different side-effect signature.
The clinical translation: bupropion does not cause sexual dysfunction, does not cause weight gain (often weight loss), and is activating rather than sedating. The trade-off is a meaningful increase in seizure risk at high doses, an absolute contraindication in eating disorders, and an insomnia/anxiety burden in some patients.
Indikace a dávkování
| Indikace | Počáteční dávka | Cílová dávka | Maximální dávka |
|---|---|---|---|
| Major depression — XL | 150 mg OD morning | 300 mg OD | 450 mg |
| Major depression — SR | 150 mg OD × 3 d → BID | 150 mg BID | 200 mg BID |
| Smoking cessation | 150 mg OD × 3 d → BID (SR) or 150 mg OD × 1 wk → 300 mg (XL) | 150 mg BID or 300 mg OD × 7–12 weeks | — |
| Seasonal affective disorder (XL) | 150 mg OD autumn start | 300 mg OD | — |
| SSRI sexual dysfunction (off-label) | 75–150 mg OD | 150 mg OD | 300 mg |
Důležité bezpečnostní aspekty
Bupropion lowers seizure threshold. Absolute contraindications: any seizure disorder, current or historical anorexia nervosa or bulimia, abrupt withdrawal from alcohol or sedatives. The seizure risk at 300 mg/day is approximately 0.1%; at 450 mg/day it is approximately 0.4% — a 4-fold rise. Single doses must not exceed 150 mg (SR) or 450 mg total (XL).
Anorexia and bulimia are absolute contraindications — both because eating-disorder physiology lowers seizure threshold (electrolyte derangement, ketotic state) and because bupropion’s appetite-suppressant effect can entrench restrictive behaviour. This is one of the few clear “do not use” boxes in psychiatry.
14-day washout each direction. Concurrent use risks hypertensive crisis.
Všechna antidepresiva nesou černé varování FDA ohledně zvýšeného rizika sebevražedných myšlenek u pacientů mladších 25 let.
Časté nežádoucí účinky
- Stimulating profile: insomnia (avoid evening dosing), dry mouth, headache, agitation, tremor.
- Kardiovaskulární: small BP rise, tachycardia, palpitations.
- Váha: weight loss is common — bupropion is one of the components of the Contrave anti-obesity combination.
- Sexuální funkce: none; often improves SSRI-induced sexual dysfunction when added.
- Gastrointestinální: nausea (worse with high single doses), constipation.
- Skin: rash, occasionally serious cutaneous reactions.
Interakce léků
- MAOIs — absolute contraindication.
- Strong CYP2B6 inducers/inhibitors (rifampicin, ritonavir, efavirenz, ticlopidine, clopidogrel, prasugrel) — alter bupropion levels; CYP2B6 inhibition by clopidogrel reduces hydroxybupropion (active metabolite) — modest clinical impact.
- CYP2D6 substrates (most TCAs, many antipsychotics, type 1c antiarrhythmics, codeine, tramadol, tamoxifen) — bupropion is a strong CYP2D6 inhibitor; raises substrate levels.
- Other seizure-threshold-lowering drugs (tramadol, fluoroquinolones, theophylline, antipsychotics) — additive risk.
Těhotenství, kojení, pediatrie
Pregnancy: limited data; not first-line antidepressant in pregnancy but no clear teratogenic signal. Breastfeeding: passes into milk; sometimes preferred for postpartum depression where weight gain or sedation would be problematic. Paediatric: not first-line; off-label use for ADHD is described.
Skladování
Store at 15–25 °C in original packaging.
Často kladené dotazy
Why is Bulet SR sometimes preferred over SSRIs?
Three reasons: no sexual side effects, weight-neutral or weight-reducing, and activating rather than sedating. Patients who develop SSRI-induced sexual dysfunction or weight gain often do well on bupropion, alone or as augmentation.
Can Bulet SR be used to quit smoking?
Yes — bupropion is FDA-approved for smoking cessation under the trade name Zyban. The dose schedule is the same as for depression (300 mg/day). Start 1–2 weeks before the planned quit date and continue for 7–12 weeks. The mechanism for nicotine cessation is partly noradrenergic withdrawal-symptom suppression and partly dopamine-mediated craving reduction.
How is Bulet SR different from a stimulant?
Bupropion has weak stimulant properties but is not a controlled substance, does not produce euphoria at therapeutic doses, and has no abuse potential in oral form. Recreational misuse via insufflation has been described but is rare and unrewarding compared to true stimulants.
Can Bulet SR cause anxiety?
Yes — the activating profile produces anxiety, jitteriness, or insomnia in some patients, particularly in the first 1–2 weeks. This is why bupropion is generally not first-line for depression with prominent anxiety symptoms. Take in the morning to minimise insomnia.
Why is Bulet SR contraindicated in eating disorders?
Anorexia and bulimia produce electrolyte derangement and ketotic state, both of which lower seizure threshold. Bupropion further lowers seizure threshold, and the combination produced unacceptable seizure rates in early trials. The contraindication is absolute, not relative.
Will Bulet SR keep me awake at night?
If taken in the evening, often yes. Standard practice is to take Bulet SR in the morning; for SR, BID dosing is morning and early afternoon (not evening).
How do I stop Bulet SR?
Bupropion has a relatively short half-life and modest withdrawal — but a taper over 1–2 weeks is still the conservative move. Halve the dose for 1–2 weeks, then stop.
Can Bulet SR be combined with an SSRI?
Yes — common combination, particularly when adding bupropion to an SSRI to counter sexual side effects or to augment partial response. Both drugs influence different neurotransmitter systems; combination is well-tolerated. Specialist supervision recommended.
What is the seizure risk?
At 300 mg/day (typical target dose), seizure risk is approximately 0.1% per year — low but real. At 450 mg/day, the risk rises to approximately 0.4%. The risk is concentrated in patients with predisposing factors: head injury history, seizure disorder, eating disorder, alcohol or sedative withdrawal.
Co když vynechám dávku?
Take as soon as remembered the same day. Do not double up — the dose-dependent seizure risk is the reason. If close to next dose, skip.
Další léky na duševní zdraví
- Mirtaz (Mirtazapine NaSSA)
- Agoprex (Agomelatine — melatonergic)
- Flunil (Fluoxetine SSRI)
- Duvanta (Duloxetine SNRI)
- Champix (Varenicline — smoking cessation alternative)
Další možnosti v oblasti duševního zdraví a psychiatrických léků
Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 150 mg |
|---|---|
| Množství | 30 tablet/ks, 60 tablet/ks, 90 tablet/ks, 180 tablet/ks |
Bulet SR
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Bulet SR
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