Lobet
Lobet is labetalol 100 mg tablets — combined alpha-1 + non-selective beta blocker. Preferred antihypertensive in pregnancy (first-line for gestational hypertension and preeclampsia). Also for hypertensive urgency / emergency (IV formulation) and aortic dissection. Standard oral dose 100-400 mg twice daily.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Quick Answer — What is Lobet?
Lobet je 100 mg labetalol tablet from a WHO-GMP certified manufacturer — non-selective beta-blocker with additional alpha-1 blockade (beta:alpha ratio ~3:1 oral, 7:1 IV). Primary use is hypertension; also used for angina, arrhythmia control, post-myocardial-infarction secondary prevention, and as first-line antihypertensive in pregnancy. Typical hypertension dose: 100 mg twice daily; titrate to 200-400 mg BID if needed (800 mg/day usual max; up to 2,400 mg/day in severe cases). Contraindicated in asthma, severe bradycardia, second/third-degree heart block, acute decompensated heart failure, and phaeochromocytoma without prior alpha-blockade. Do NOT stop abruptly — taper over 1-2 weeks to avoid rebound tachycardia / angina / MI.
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What Is Lobet?
Lobet is an oral tablet containing labetalol 100 mg from a WHO-GMP certified manufacturer, supplied in 30-180 tablets. Labetalol is a non-selective beta-blocker with additional alpha-1 blockade (beta:alpha ratio ~3:1 oral, 7:1 IV). Combined alpha-1 and non-selective beta blockade gives rapid BP-lowering without reflex tachycardia. First-line antihypertensive in pregnancy — one of the three “pregnancy-safe” options alongside methyldopa and nifedipine. Also the standard drug for hypertensive emergencies including preeclampsia, hypertensive crisis, and phaeochromocytoma (after alpha-blockade).
How Labetalol Lowers Blood Pressure
Beta-blockers reduce blood pressure through four mechanisms:
- Reduction of cardiac output — beta-1 blockade in the sinoatrial node reduces heart rate, and blockade in ventricular myocardium reduces contractility. Lower cardiac output = lower blood pressure.
- Renin-angiotensin suppression — beta-1 blockade in juxtaglomerular cells reduces renin release, lowering angiotensin II and aldosterone over 2-4 weeks. This accounts for much of the long-term BP effect.
- Central sympathetic reduction — lipophilic beta-blockers cross the blood-brain barrier and reduce central sympathetic outflow.
- Alpha-1 blockade — direct peripheral vasodilation (labetalol-specific), giving a faster BP reduction than pure beta-blockers.
Beta-blockers are moderately lipophilic. Plasma half-life of labetalol is 6-8 hours.
Approved and Evidence-Based Uses
- Hypertension (primary indication)
- Hypertension in pregnancy — first-line; safer than most other BP drugs (no teratogenic signal, preferable to methyldopa in many UK/EU guidelines)
- Preeclampsia / severe gestational hypertension
- Hypertensive emergency / urgency (IV)
- Phaeochromocytoma — ONLY after alpha-blockade established (like all beta-blockers; never as first agent)
- Aortic dissection — IV labetalol plus morphine for BP/HR control
Lobet Dosage
Adult hypertension dose: 100 mg twice daily; titrate to 200-400 mg BID if needed (800 mg/day usual max; up to 2,400 mg/day in severe cases).
Start low, titrate upward over 2-4 weeks to target BP (typically <140/90 in uncomplicated hypertension; <130/80 in diabetes, chronic kidney disease, or established cardiovascular disease). Check resting pulse before each dose-increase — do not titrate if <55 bpm.
Monitoring:
- Resting pulse and BP at 2, 4, and 8 weeks after starting or dose change
- Baseline ECG if any cardiac history; periodic ECG if symptoms change
Administration: swallow whole with water. Take at approximately the same time each day.
Discontinuation: NEVER stop abruptly. Taper over 1-2 weeks (reduce by 25-50% every 3-5 days). Abrupt discontinuation causes rebound tachycardia, worsened angina, and — in patients with coronary disease — can precipitate myocardial infarction. This is one of the most important safety points for beta-blockers.
Side Effects
Common (>5%):
- Fatigue, lethargy — often adapts over 2-4 weeks
- Cold hands and feet (peripheral vasoconstriction)
- Bradycardia (check pulse; stop if <50 bpm)
- Exercise intolerance — maximum heart rate is blunted by beta blockade
- Dizziness, postural hypotension
- CNS effects possible but less common than with propranolol
- Postural dizziness (more common due to vasodilator component)
Less common: depression, reduced libido / erectile dysfunction, gastrointestinal upset, Raynaud-like cold intolerance, bronchospasm (more common with non-selective agents).
Important but uncommon:
- Masked hypoglycaemia in diabetics — beta-blockers blunt the tachycardia / tremor warning signs of low blood sugar. Monitor glucose more carefully; prefer nebivolol or bisoprolol in insulin-treated diabetes.
- Bronchospasm — can be severe in asthma / COPD. Absolute contraindication for non-selective agents; relative for cardioselective.
- Heart block or worsening heart failure — in susceptible patients. Start low, titrate slowly.
Contraindications & Cautions
- Asthma / severe COPD / any bronchospastic disorder — absolute contraindication (non-selective beta blockade)
- Second or third-degree atrioventricular block (without pacemaker)
- Sinus bradycardia <50 bpm
- Cardiogenic shock, decompensated heart failure requiring inotropes
- Severe peripheral arterial disease, Raynaud’s syndrome (relative)
- Phaeochromocytoma without prior alpha-blockade — paradoxical hypertensive crisis (Labetalol has alpha-1 blocker component, which softens but does not eliminate this risk)
- Severe hepatic impairment (for extensively hepatic-metabolised agents: propranolol, metoprolol, carvedilol, labetalol)
- Severe renal impairment — dose adjustment needed for renal-excreted agents (atenolol, nadolol)
- Hypersensitivity to labetalol
Pregnancy: Labetalol is the first-line antihypertensive in pregnancy — safer than most alternatives; no teratogenic signal; widely used for gestational hypertension and preeclampsia.
Breastfeeding: compatible (low milk transfer).
Interakce s léčivy
- Verapamil, diltiazem (non-dihydropyridine CCBs) — additive bradycardia, heart block, and negative inotropy; generally avoid combination. Dihydropyridine CCBs (amlodipine, nifedipine) are safer to combine with beta-blockers.
- Other beta-blockers — do not combine; additive bradycardia
- Clonidine — if stopping clonidine, stop the beta-blocker first (several days before) to avoid rebound hypertensive crisis
- Insulin and sulphonylureas — mask hypoglycaemia warning signs; monitor glucose closely
- NSAIDs — reduce the antihypertensive effect of beta-blockers; avoid chronic combination
- Alkohol — additive hypotension and CNS depression (particularly for lipophilic agents)
Beta-Blocker Class at a Glance
| Beta-blocker | Selectivity | Best for |
|---|---|---|
| Propranolol (Inderal, Ciplar, Beloc) | Non-selective | Migraine, tremor, thyrotoxicosis, performance anxiety, HTN |
| Metoprolol | Cardioselective | Post-MI, HF-REF (succinate ER), angina, AF rate control |
| Carvedilol | Non-selective + α-1 | HF-REF (mortality evidence), post-MI |
| Bisoprolol | Highly cardioselective | HF-REF, HTN, angina, AF rate control |
| Nebivolol | Ultra-selective + NO | Elderly, metabolic syndrome, erectile dysfunction |
| Atenolol | Cardioselective (hydrophilic) | Angina, AF rate control (second-line for HTN) |
| Labetalol | Non-selective + α-1 | Pregnancy hypertension, hypertensive crisis |
The combined alpha + beta profile avoids reflex tachycardia seen with pure alpha-blockers (prazosin) and the reflex vasoconstriction seen with pure beta-blockers. First-choice beta-blocker in pregnancy. Do not use as monotherapy for phaeochromocytoma before alpha-blockade — paradoxical hypertensive crisis.
Storage
Store Lobet below 25°C. Keep out of reach of children — accidental paediatric beta-blocker ingestion can cause life-threatening bradycardia and hypoglycaemia.
Často kladené dotazy
How long does Lobet take to lower blood pressure?
You should see some BP reduction within 1-2 days of starting; the full antihypertensive effect takes 2-4 weeks (driven by the gradual renin-angiotensin suppression, not the immediate heart-rate effect). Measure BP at home at the same time each day to track response.
Can I take Lobet if I have asthma?
No — Labetalol is non-selective and can cause severe bronchospasm in asthmatics. Absolute contraindication. For asthmatic patients needing a beta-blocker, nebivolol or bisoprolol (highly cardioselective) are safer alternatives — though no beta-blocker is completely safe in asthma.
Why should I never stop Lobet abruptly?
Abrupt discontinuation causes rebound tachycardia and worsened angina within 24-48 hours, driven by up-regulation of beta receptors during chronic blockade. In patients with coronary artery disease, this can precipitate myocardial infarction or unstable angina. Always taper over 1-2 weeks when stopping.
Will Lobet affect my exercise performance?
Yes — beta blockade blunts the heart-rate response to exercise, so your maximum pulse is lower and you fatigue faster at high intensities. For recreational exercise most people adapt; for competitive endurance athletes, beta-blockers can meaningfully impair performance and are banned in precision sports (shooting, archery — where they reduce physiological tremor).
Will Lobet affect my blood sugar if I have diabetes?
Beta-blockers mask the tachycardia / tremor / palpitation warning signs of hypoglycaemia, making low blood sugar harder to detect. They can also blunt the counter-regulatory glucose response. Monitor glucose more frequently on a beta-blocker, particularly if on insulin or sulphonylureas. Nebivolol and bisoprolol have the best metabolic profile.
Can I drink alcohol on Lobet?
Moderate alcohol is generally acceptable but alcohol potentiates the hypotensive and CNS-depressant effects. Stand up slowly after drinking. Alcohol is also an independent BP-raiser; reducing intake can improve BP control independent of Lobet.
Does Lobet cause weight gain?
Older beta-blockers (propranolol, atenolol, metoprolol) are associated with modest weight gain (1-3 kg) and worsening of insulin sensitivity over time. Nebivolol and carvedilol are weight-neutral or slightly weight-favourable due to their vasodilator components. For patients with metabolic syndrome, nebivolol is the preferred beta-blocker when one is needed.
Is Lobet safe in pregnancy?
Yes — labetalol is the first-line antihypertensive in pregnancy. Widely used for gestational hypertension and preeclampsia; decades of real-world safety data.
Can I take Lobet with other BP medications?
Yes — beta-blockers combine well with dihydropyridine calcium-channel blockers (amlodipine), ACE inhibitors (ramipril, lisinopril), ARBs (losartan, telmisartan, olmesartan), and thiazide diuretics (HCTZ). Avoid combination with non-dihydropyridine CCBs (verapamil, diltiazem) — additive bradycardia and heart-block risk.
Where can I buy Lobet online?
You can buy Lobet (labetalol 100 mg tablet, 30-180 tablets) from MedsBase with discreet packaging and worldwide shipping.
Related Beta-Blockers & Antihypertensives
- Carvejohn — Carvedilol 12.5/25 mg
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- Concor — Bisoprolol 5/10 mg (HTN dose)
- Concor Cor — Bisoprolol 2.5 mg (HF starter)
- Metomac — Metoprolol 25 mg
- Provanol SR — Propranolol 80 mg SR
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