Thymalin (Khavinson Thymic Polypeptide Bioregulator)
✅ Multi-component thymic polypeptide preparation (Khavinson bioregulator class)
✅ Mixture of short oligopeptides (di- through hexapeptides) — not a single sequence
✅ Thymic-axis T-cell maturation + age-related thymic involution research
✅ Published Russian-research immune-modulator (St. Petersburg Gerontology Institute)
✅ Lyophilized HPLC ≥99% with batch-fingerprint COA
Thymalin contains multi-component thymic-derived polypeptide bioregulator preparation.
✓ Ιατρικά ελεγμένο από Morgan Ellis — Ερευνητής Φαρμακευτικής · 8 χρόνια εμπειρία · Τελευταία αναθεώρηση: Μάιος 2026
Quick Answer — What is Thymalin?
Thymalin is a polypeptide preparation extracted from calf or porcine thymus tissue, developed by Khavinson and colleagues at the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1970s. Unlike single-peptide research compounds, Thymalin is a multi-component peptide complex (typical MW range 1–10 kDa across the mixture) consisting of short oligopeptide bioregulators that originate in thymic stromal cells. The most cited active components are tetrapeptide EW (Glu-Trp) and other Khavinson-class short peptide bioregulators. Thymalin is used in published Russian and Eastern European research as a thymus-axis immune-modulator that promotes T-cell maturation, restores age-related thymic involution markers, and modulates neuroendocrine-immune crosstalk. For laboratory research use only. Polypeptide bioregulator preparation — not a single-sequence peptide.
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| Προδιαγραφή | Λεπτομέρεια |
|---|---|
| Compound Class | Polypeptide bioregulator preparation (multi-component thymic peptide mixture); Khavinson-class peptide bioregulator |
| Source | Tissue-extracted from calf or porcine thymus; purified by acid extraction + chromatographic fractionation |
| Αριθμός CAS | Multi-component preparation — no single canonical CAS; identification by HPLC fingerprint and bioactivity assay |
| Μοριακός Τύπος | Multi-component thymic polypeptide bioregulator (Khavinson preparation) — heterogeneous low-molecular-weight peptide pool from calf thymus ultrafiltrate, < 10 kDa. No single molecular formula due to multi-peptide composition; activity assigned to the short-peptide fraction. |
| Active Components | Mixture of short oligopeptides (di- through hexapeptides predominantly), MW range ~200–10,000 Da. Best-characterised components include thymic dipeptide EW (Glu-Trp) and other Khavinson short-peptide bioregulators. |
| Mechanism | Multi-component thymus-axis immune modulation. Published research attributes effects to: (1) promotion of T-cell precursor maturation in thymic cortex and medulla; (2) restoration of age-related thymic involution markers (improved TREC count, increased thymic-output naive T-cell production); (3) modulation of cytokine balance (IL-2, IFN-γ upregulation in lymphocyte cultures); (4) crosstalk with hypothalamic-pituitary axis via the Khavinson-peptide bioregulator network. |
| Form / Purity | Lyophilized white-to-pale-yellow amorphous powder; ≥99% HPLC purity (multi-component preparation; HPLC profile-fingerprint COA available) |
| Αποθήκευση | Lyophilized: 2–8 °C short-term, −20 °C long-term. Reconstituted: 2–8 °C, use within 30 days. Avoid freeze-thaw. |
| Ερευνητική Χρήση | For laboratory research use only. Not for human or veterinary diagnostic or therapeutic use. Thymalin has clinical-use approval in Russia and several CIS countries but is not approved by FDA / EMA / MHRA. Not on the WADA Prohibited List. |
Mechanism of Action — Thymic-Axis Bioregulator
Thymalin is the canonical Khavinson-class peptide bioregulator derived from thymic tissue. The Khavinson bioregulator concept (developed at the St. Petersburg Institute of Bioregulation and Gerontology from the 1970s) posits that tissue-specific short peptides act as inter-organ signalling molecules that maintain age-appropriate tissue function — and that age-related decline reflects loss of these peptide bioregulator signals from the source tissue. Thymalin is the original member of this class and is used in published Russian research as the canonical thymus-axis bioregulator.
Mechanism of action across published research:
- T-cell precursor maturation — promotes differentiation of CD4-CD8- thymocyte precursors through CD4+CD8+ double-positive stage and into mature CD4+ or CD8+ T-cell exit populations
- Thymic involution reversal — published rodent and human-subject research reports improvement in age-related thymic-involution markers (increased thymic-output TREC count, improved naive-T-cell ratio)
- Cytokine modulation — published in-vitro lymphocyte culture work reports upregulation of IL-2 and IFN-γ production
- Neuroendocrine-immune crosstalk — Khavinson-class peptides are proposed to modulate hypothalamic-pituitary-immune integration
- Anti-ageing / longevity research — multi-decade Russian-research cohort follow-up has reported reduced age-adjusted mortality in elderly populations receiving repeated Thymalin courses (controversial — not replicated in Western trials)
Published Research Applications
- Khavinson bioregulator pharmacology — canonical thymic-axis research compound
- Thymic involution research — age-related T-cell production decline
- Immune-system aging research — naive-T-cell production, TREC count
- Cytokine-network modulation — IL-2, IFN-γ research
- Comparative thymic-peptide research — compared with Επιταλόν (pineal-axis bioregulator) and other Khavinson short peptides
For broader context, see Επιταλόν (Khavinson pineal tetrapeptide), Pinealon (Khavinson tripeptide), Thymosin Alpha-1 (single-sequence thymic immune peptide — direct comparison), and the full peptide research catalog.
Available Strengths
| Vial Strength | Pack Sizes |
|---|---|
| 10 mg — research-protocol standard; mirrors clinical-use vial format from Russian Thymalin preparations | 10 or 20 vials |
How It Compares — Thymalin vs Thymosin Alpha-1
Both are thymic-derived immune peptides, but they differ fundamentally in molecular nature. Thymosin Alpha-1 is a defined single-sequence 28-amino-acid peptide (CAS 62304-98-7, MW 3108) with characterised mechanism (PRR-pathway and T-cell-axis modulation). Thymalin is a multi-component polypeptide preparation derived from whole thymic tissue extract — containing multiple short oligopeptides whose individual identities and proportions vary slightly between batches. Researchers studying defined-mechanism single-peptide pharmacology use Thymosin Alpha-1; those studying broader Khavinson-bioregulator-class thymic-extract effects use Thymalin.
Storage and Reconstitution
Lyophilized 2–8 °C short-term, −20 °C long-term. Reconstitute in bacteriostatic water (1.0 mL per 10 mg vial → 10 mg/mL). Swirl gently. Store reconstituted at 2–8 °C, use within 30 days.
FAQ
Is Thymalin a single peptide or a mixture?
Thymalin is a multi-component polypeptide preparation — a mixture of short oligopeptides (mostly di-, tri-, tetra- and hexapeptides) extracted from thymic tissue. It is not a single-sequence peptide. The HPLC fingerprint is reproducible batch-to-batch but the preparation is characterised by mixture composition rather than single CAS / sequence.
How is Thymalin different from Thymosin Alpha-1?
Thymalin is a multi-component thymic extract; Thymosin Alpha-1 is a defined single-sequence 28-aa peptide. They are mechanistically related (both modulate thymic-axis immune function) but molecularly distinct.
What dose ranges are used in research?
Russian-clinical protocols use 5–20 mg/d IM for 5-10 day courses. In-vitro lymphocyte-culture studies use micromolar peptide-mixture concentrations.
Other Khavinson / Immune Bioregulator Research Peptides
- Thymosin Alpha-1 — Defined single-sequence 28-aa thymic peptide — direct comparison
- Επιταλόν — Khavinson pineal-axis tetrapeptide
- Pinealon — Khavinson tripeptide bioregulator
- Selank — Russian-developed anxiolytic / immune-modulating peptide
- Semax — Russian-developed nootropic peptide
- BAC Water (Bacteriostatic Water) — Required for reconstituting any lyophilized vial — sterile, 0.9% benzyl-alcohol-preserved diluent
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| Ισχύς | 10 mg |
|---|---|
| Ποσότητα | 10 Vials, 20 Vials, 30 Vials |
Thymalin (Khavinson Thymic Polypeptide Bioregulator)
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Thymalin (Khavinson Thymic Polypeptide Bioregulator)
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