Duphaston
✅ Regulates Menstrual Cycle
✅ Treats Menstrual Disorders
✅ Supports Pregnancy
✅ Prevents Miscarriage
✅ Prescribed Hormonal Therapy
Duphaston contains Dydrogesterone.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
💡 Snel antwoord
Duphaston is dydrogesterone 10 mg, a retroprogesterone (stereoisomer of progesterone) with selective progestogenic activity — no androgenic, estrogenic, or glucocorticoid effects. Used for: HRT progestin opposition, threatened and recurrent miscarriage, endometriosis, secondary amenorrhoea, dysfunctional uterine bleeding, en PMS. Favourable safety profile — no breast cancer signal in observational studies.
📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.
Waarom bestellen bij MedsBase
Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.
What Is Duphaston?
Duphaston is a branded generic of dydrogesterone, a stereoisomer of natural progesterone. Its molecular structure gives it highly selective progesterone receptor activity — without the androgenic, estrogenic, anti-mineralocorticoid, or glucocorticoid effects of other progestins. It is orally bioavailable (unlike micronized progesterone, which requires a special formulation) and has a 16–18 hour half-life. Manufactured by Abbott.
Genitale herpes (eerste episode):
- HRT progestin opposition: 10 mg daily (continuous-combined) or 10 mg for 14 days/cycle (sequential).
- Threatened miscarriage: 40 mg loading then 10 mg twice daily until bleeding stops (PRISM trial subgroups).
- Recurrent miscarriage: 10 mg twice daily from ovulation through week 12–20 (LOTUS I and II trials show improved pregnancy rates in IVF).
- Secondary amenorrhoea: 10 mg twice daily for 10 days with estradiol.
- Dysfunctional uterine bleeding: 10 mg twice daily for 5–7 days to stop bleeding, cyclic thereafter.
- Endometriosis: 10 mg 2–3 times daily from day 5 to day 25 of cycle.
- IVF luteal phase support: 10 mg three times daily starting at embryo transfer.
- PMS / PMDD: 10 mg twice daily from day 12 to day 26 of cycle.
Hoe in te nemen
- Swallow tablet whole with water, with or without food.
- Dose and timing depend on indication — follow the prescribing clinician’s schedule carefully.
- For HRT, dydrogesterone is the oral progestin of choice for women who dislike the sedation of micronized progesterone.
- For pregnancy support, continue until week 12–20 per fertility specialist; do not stop abruptly during active use.
Dydrogesterone vs Other Progestins
| Progestin | Profile |
|---|---|
| Dydrogesterone | Selective progesterone receptor; no androgenic, estrogenic, or glucocorticoid effects; no known breast cancer signal |
| Micronized progesterone | Bioidentical; sedative (via GABA-A metabolite); poor oral bioavailability unless micronized |
| Medroxyprogesterone | Mild androgenic, mild glucocorticoid; associated with modestly elevated breast cancer risk in WHI data |
| Norethisterone | Androgenic; effective in dysfunctional bleeding and endometriosis; cardiovascular considerations |
Bijwerkingen
Vaak voorkomend: headache, migraine, nausea, breast tenderness, breakthrough bleeding, spotting.
Minder vaak: depression, allergic skin reaction, weight change.
Zeldzaam: cholestasis, jaundice, VTE (much less than estrogens or combined OCPs).
Who Should Not Take Duphaston
- Known or suspected pregnancy (unless used as pregnancy support under clinical guidance)
- Undiagnosed vaginal bleeding
- History of breast cancer
- Actieve leverziekte
- Active thromboembolic disorder
- Overgevoeligheid bekend
Opslag
Store at room temperature (below 30 °C). Keep in original blister. Keep out of reach of children.
Veelgestelde vragen
How does dydrogesterone differ from natural progesterone?
Dydrogesterone is a stereoisomer — the molecules have the same atoms but a flipped 3D shape. The flip gives selective progesterone-receptor binding (no androgenic/estrogenic/mineralocorticoid effects) and eliminates the sedative property of natural progesterone.
Is duphaston safe in pregnancy?
Widely used for threatened miscarriage and IVF support. The LOTUS and PRISM trials support its safety and efficacy in these indications. Generally considered safe in pregnancy under clinician guidance.
Can I use duphaston for PMS?
Yes — cyclic dydrogesterone (day 12–26) is traditionally used for luteal phase support in PMS. Modern evidence favours SSRIs for severe PMS/PMDD, but dydrogesterone remains an option particularly when SSRIs are not tolerated.
Will duphaston make me gain weight?
Small weight fluctuations reported; generally considered weight-neutral in trials.
Is dydrogesterone safer than medroxyprogesterone?
Observational data (E3N cohort) suggest dydrogesterone and micronized progesterone have a more favourable breast-cancer profile than synthetic progestins like medroxyprogesterone when used for HRT.
Can I take duphaston while breastfeeding?
Small amounts pass into breast milk. Generally considered compatible with breastfeeding for short courses; discuss with clinician.
Wat als ik een dosis vergeet?
Take as soon as you remember unless nearly time for the next dose. Do not double-dose.
Can I use duphaston for endometriosis?
Yes — 10 mg 2–3 times daily cyclically (day 5–25). Modern alternatives (combined OCPs, Mirena IUD, GnRH agonists) are often preferred, but dydrogesterone remains useful in specific cases.
Related Women’s Health Products
- Tamodex (Tamoxifen 10 mg)
- Tamilong (Tamoxifen 20 mg)
- Letroheal (Letrozole 2.5 mg)
- Etibo (Lapatinib 250 mg)
- Deviry (Medroxyprogesterone 10 mg)
- Naprosyn (Naproxen 250 mg)
- Candid-V Gel (Clotrimazole)
⚕️ Medische disclaimer: Information is educational and does not replace medical advice. Consult a clinician before starting, stopping, or changing any medication, particularly for cancer therapy, hormonal treatments, and prescription products.
Gerelateerde alternatieven
Andere producten in Vrouwengezondheid die klanten ook bekijken:
More options in Fertility Supplements for Women
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 10 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Duphaston
Vragen & antwoorden
Duphaston
Gerelateerde producten
Beoordelingen
Er zijn nog geen beoordelingen