Ebasil
✅ Relieves Allergy Symptoms
✅ Reduces Itching & Sneezing
✅ Controls Hay Fever
✅ Non-Drowsy Formula
✅ Prescribed Antihistamine Medication
Ebasil contains Ebastin.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Ebasil?
Ebasil is een merk van ebastine (10 mg), a second-generation, non-sedating oral antihistamine gebruikt voor hay fever (allergic rhinitis), chronic idiopathic urticaria (hives), itchy skin, and allergic conjunctivitis. It blocks histamine H1 receptors in the peripheral tissues that drive allergy symptoms — sneezing, runny nose, itchy eyes, skin hives — without crossing the blood-brain barrier meaningfully, so it does not make most people drowsy. Onset: 1–3 hours; duration: 24 hours. Once-daily dosing. A pro-drug converted in the liver to the active metabolite carebastine. Widely used across Europe, Latin America, and Asia; not marketed in the US or Canada. 20 mg dose approved for severe symptoms — a useful “step-up” option. Safe for long-term daily use (months to years) in most adults. Common side effects: mild headache, dry mouth, fatigue. Avoid in known hypersensitivity; dose-reduce in significant renal impairment.
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What Is Ebasil?
Ebasil is an oral antihistamine containing ebastine (10 mg), supplied as tablets. Manufactured by WHO-GMP certified manufacturer, in packs of 30, 60, 90 or 180 tablets. Originator brand: Kestine / Ebastel (Almirall, 1990s EU).
ebastine belongs to the second-generation (non-sedating) H1 antihistamine class — developed to keep the allergy-blocking effect of older drugs like diphenhydramine or pheniramine while removing the sedation, dry mouth, and cognitive impairment caused by their passage into the brain. Second-generation agents are the first-line oral antihistamines for allergic rhinitis and chronic urticaria in every major allergy guideline (ARIA, EAACI, AAAAI).
What Is Ebasil Used For?
- Seasonal allergic rhinitis (hay fever) — sneezing, runny nose, itchy nose, itchy/watery eyes caused by pollens (tree, grass, weed)
- Perennial allergic rhinitis — year-round symptoms from dust mites, pet dander, mould
- Chronic idiopathic urticaria (hives) — recurring itchy welts lasting > 6 weeks
- Allergische conjunctivitis — itchy, watery, red eyes from allergens
- Mild allergic skin reactions — pruritus (itch), insect bite reactions, mild contact urticaria
Het is niet a treatment for anaphylaxis (use adrenaline/epinephrine auto-injector), asthma (use inhaled corticosteroid + bronchodilator), or allergic food reactions beyond mild skin symptoms.
How Does Ebasil Work?
When you are exposed to an allergen (pollen, dust, animal dander), mast cells and basophils in the skin and mucosa release histamine. Histamine binds H1 receptors and causes the classic allergy cascade: vasodilation, vascular leakage, itch, sneeze, increased mucus secretion, and smooth-muscle contraction.
ebastine is a selective inverse agonist at H1 receptors. It stabilises the receptor in its inactive state, reducing signalling even at baseline histamine levels. Key features of the second-generation class:
- Peripheral H1 selectivity — strong binding in nose, skin, conjunctiva; minimal binding in the brain
- Poor blood-brain barrier penetration — so little to no sedation
- Minimal anticholinergic activity — unlike 1st-gen agents, no dry mouth, urinary retention, or constipation at therapeutic doses
- No tachyphylaxis — effect does not fade over weeks of daily use (a common misconception)
Dosering en toediening
Standaard dosering: 10 mg once daily in adults and children aged 12+; may be doubled to 20 mg/day for severe symptoms. Children 6–11: 5 mg/day.
- Onset of action: 1–3 hours.
- Peak effect: 2.6–4 hours.
- Duration: 24 hours — so once-daily dosing is sufficient for most patients.
- Dosis vergeten? Take it as soon as you remember unless your next dose is due within a few hours; do not double up.
- Seasonal use. Start 1–2 weeks before your usual pollen trigger season for best effect; continue daily through the season.
- Chronic urticaria. Guidelines allow up-dosing to 2–4× standard dose if symptoms are not controlled — done under medical supervision.
Bijwerkingen
Low sedation — similar to loratadine, less than cetirizine at equivalent doses.
Common (< 5% in most trials):
- Mild headache
- Droge mond
- Vermoeidheid
- Nausea or abdominal discomfort
Minder vaak voorkomend:
- Dizziness, sleep disturbance
- QT-interval effects at supratherapeutic doses (exceedingly rare at standard doses; more relevant historically for the withdrawn agents terfenadine and astemizole, not for current second-generation antihistamines)
- Hypersensitivity reactions, rash
- Transient transaminase elevation
Geneesmiddelinteracties
- Alcohol and CNS depressants — additive drowsiness (minor for non-sedating agents; avoid high-dose combinations).
- Ketoconazole, erythromycin, clarithromycin, ritonavir — may modestly raise plasma levels of loratadine/desloratadine/ebastine via CYP3A4 inhibition. Clinical effect usually small.
- Fruit juice (grapefruit, orange, apple) — significantly reduces fexofenadine absorption (~30–40%). Take with water.
- Antacids containing aluminium/magnesium — reduce fexofenadine absorption; separate by 2 hours.
- Pimozide, QT-prolonging drugs — caution; avoid high-dose combinations.
Use in Pregnancy and Children
Zwangerschap: Limited dedicated data; cetirizine and loratadine are usually preferred first-line in pregnancy where choice exists.
Borstvoeding: second-generation antihistamines pass into breast milk in tiny amounts and are considered compatible with breastfeeding. Loratadine and cetirizine have the most data.
Kinderen: Approved from age 6 years in many markets.
Who Should Not Take Ebasil?
- Known hypersensitivity to ebastine or other antihistamines in the same class
- Severe renal impairment without dose adjustment
- End-stage renal disease on haemodialysis (dose per nephrology guidance)
- Severe hepatic impairment — dose reduction recommended for some molecules
- Children below the age cutoff for the formulation
- Pregnancy / breastfeeding — use only under medical advice; loratadine and cetirizine are preferred where choice exists
Opslag
Store Ebasil below 25°C in a dry place, in the original blister. Keep out of reach of children.
Veelgestelde vragen
Is Ebasil the same as ebastine?
Yes — Ebasil contains the active ingredient ebastine. Bioequivalence to the originator brand (Kestine / Ebastel (Almirall, 1990s EU)) is required by regulatory authorities, so clinical effect is the same at the same dose.
Is ebastine as effective as loratadine or cetirizine?
In head-to-head trials, ebastine 10 mg has shown similar efficacy to loratadine 10 mg and cetirizine 10 mg for allergic rhinitis. Ebastine 20 mg is moderately more effective than either — a useful option when standard doses of other antihistamines are insufficient.
Will Ebasil make me drowsy?
Low sedation — similar to loratadine, less than cetirizine at equivalent doses. If you do feel drowsy, take your dose in the evening, or switch to fexofenadine (the least-sedating 2nd-generation antihistamine).
Is it safe to take Ebasil every day for months or years?
Yes — long-term daily use of 2nd-generation antihistamines is well-studied and safe for most adults. There is no tachyphylaxis (the effect does not fade), no cumulative organ toxicity, and no withdrawal syndrome. Chronic urticaria patients often take an antihistamine daily for years.
Can I take Ebasil with other allergy medications?
Yes, in most cases. Combining an oral antihistamine with an intranasal corticosteroid (e.g. mometasone, fluticasone) is the standard combination for moderate hay fever. Eye drops (olopatadine, ketotifen) can be added for eye symptoms. Avoid combining two oral antihistamines at the same time without medical advice.
How quickly does Ebasil work?
Onset is usually 1–3 hours, with peak effect at 2.6–4 hours. For seasonal hay fever, starting 1–2 weeks before your usual trigger season gives the best control.
What happens if I take more than the recommended dose?
Single-dose overdoses of 2nd-generation antihistamines rarely cause serious harm at a few multiples of the standard dose, but can cause drowsiness, tachycardia, and (rarely) QT prolongation. Seek medical advice if more than 5× the standard dose has been taken, especially in children.
Where can I buy Ebasil online?
You can order Ebasil (10 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.
Related Allergy Medications
- Allegra — Fexofenadine (least-sedating antihistamine)
- Xyzal — Levocetirizine (cetirizine’s active enantiomer)
- Okacet — Cetirizine (generic Zyrtec)
- Lorfast Meltab — Loratadine orally dissolving
- Dazit — Desloratadine
- Meta Spray — Mometasone intranasal corticosteroid
- Arzep — Azelastine + Fluticasone nasal spray
- Browse all Hay Fever & Allergy Medications
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| Sterkte | 10 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
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