Xyzal
✅ Relieves allergy symptoms
✅ Reduces itching
✅ Controls sneezing
✅ Manages runny nose
✅ Contains Levocetirizine
Xyzal contains Levocetirizine.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Xyzal?
Xyzal is een merk van levocetirizine (5 mg), een second-generation, non-sedating oral antihistamine gebruikt voor hay fever (allergic rhinitis), chronic idiopathic urticaria (hives), itchy skin, and allergic conjunctivitis. It blocks histamine H1 receptors in the peripheral tissues that drive allergy symptoms — sneezing, runny nose, itchy eyes, skin hives — without crossing the blood-brain barrier meaningfully, so it does not make most people drowsy. Onset: 30–60 minutes; duration: 24 hours. Once-daily dosing. Pure active (R)-enantiomer of cetirizine — you get the same receptor binding at half the dose with about half the drowsiness. Evening dosing is standard. Safe for long-term daily use (months to years) in most adults. Common side effects: mild headache, dry mouth, fatigue. Avoid in known hypersensitivity; dose-reduce in significant renal impairment.
📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.
Waarom bestellen bij MedsBase
Onze generieke medicijnen zijn afkomstig van WHO-GMP gecertificeerde fabrikanten en worden wereldwijd verzonden in discrete, eenvoudige verpakkingen — geen medicijnnaam op de buitenkant van het pakket. Betalingen met kaart worden verwerkt via een gereguleerde processor (betalingsoverzichten vermelden een gereguleerde kaartbetalingprocessor — nooit “MedsBase” of een medicijnnaam). Crypto en SEPA bankoverschrijvingen worden ook geaccepteerd. Elke bestelling wordt ondersteund door ons Reshipment Assurance Policy.
What Is Xyzal?
Xyzal is an oral antihistamine containing levocetirizine (5 mg), supplied as tablets. Manufactured by UCB Pharma, in packs of 30, 60, 90 or 180 tablets. Originator brand: Xyzal (UCB, 2001 EU / 2007 US).
levocetirizine belongs to the second-generation (non-sedating) H1 antihistamine class — developed to keep the allergy-blocking effect of older drugs like diphenhydramine or pheniramine while removing the sedation, dry mouth, and cognitive impairment caused by their passage into the brain. Second-generation agents are the first-line oral antihistamines for allergic rhinitis and chronic urticaria in every major allergy guideline (ARIA, EAACI, AAAAI).
What Is Xyzal Used For?
- Seasonal allergic rhinitis (hay fever) — sneezing, runny nose, itchy nose, itchy/watery eyes caused by pollens (tree, grass, weed)
- Perennial allergic rhinitis — year-round symptoms from dust mites, pet dander, mould
- Chronic idiopathic urticaria (hives) — recurring itchy welts lasting > 6 weeks
- Allergic conjunctivitis — itchy, watery, red eyes from allergens
- Mild allergic skin reactions — pruritus (itch), insect bite reactions, mild contact urticaria
It is niet a treatment for anaphylaxis (use adrenaline/epinephrine auto-injector), asthma (use inhaled corticosteroid + bronchodilator), or allergic food reactions beyond mild skin symptoms.
How Does Xyzal Work?
When you are exposed to an allergen (pollen, dust, animal dander), mast cells and basophils in the skin and mucosa release histamine. Histamine binds H1 receptors and causes the classic allergy cascade: vasodilation, vascular leakage, itch, sneeze, increased mucus secretion, and smooth-muscle contraction.
levocetirizine is a selective inverse agonist at H1 receptors. It stabilises the receptor in its inactive state, reducing signalling even at baseline histamine levels. Key features of the second-generation class:
- Peripheral H1 selectivity — strong binding in nose, skin, conjunctiva; minimal binding in the brain
- Poor blood-brain barrier penetration — so little to no sedation
- Minimal anticholinergic activity — unlike 1st-gen agents, no dry mouth, urinary retention, or constipation at therapeutic doses
- No tachyphylaxis — effect does not fade over weeks of daily use (a common misconception)
Dosering en toediening
Standaard dosering: 5 mg once daily in the evening. Children 6–11: 2.5 mg once daily. Reduce dose or frequency in renal impairment.
- Onset of action: 30–60 minutes.
- Peak effect: 0.8–1 hour.
- Duration: 24 hours — so once-daily dosing is sufficient for most patients.
- Dosis vergeten? Take it as soon as you remember unless your next dose is due within a few hours; do not double up.
- Seasonal use. Start 1–2 weeks before your usual pollen trigger season for best effect; continue daily through the season.
- Chronic urticaria. Guidelines allow up-dosing to 2–4× standard dose if symptoms are not controlled — done under medical supervision.
Bijwerkingen
Less sedating than its parent cetirizine at equivalent clinical potency — drowsiness rates in trials are about half those of cetirizine 10 mg.
Common (< 5% in most trials):
- Mild headache
- Droge mond
- Vermoeidheid
- Nausea or abdominal discomfort
Minder vaak voorkomend:
- Dizziness, sleep disturbance
- QT-interval effects at supratherapeutic doses (exceedingly rare at standard doses; more relevant historically for the withdrawn agents terfenadine and astemizole, not for current second-generation antihistamines)
- Hypersensitivity reactions, rash
- Transient transaminase elevation
Geneesmiddelinteracties
- Alcohol and CNS depressants — additive drowsiness (minor for non-sedating agents; avoid high-dose combinations).
- Ketoconazole, erythromycin, clarithromycin, ritonavir — may modestly raise plasma levels of loratadine/desloratadine/ebastine via CYP3A4 inhibition. Clinical effect usually small.
- Fruit juice (grapefruit, orange, apple) — significantly reduces fexofenadine absorption (~30–40%). Take with water.
- Antacids containing aluminium/magnesium — reduce fexofenadine absorption; separate by 2 hours.
- Pimozide, QT-prolonging drugs — caution; avoid high-dose combinations.
Use in Pregnancy and Children
Pregnancy: Limited pregnancy-specific data, but as the active enantiomer of cetirizine it is generally considered compatible; cetirizine or loratadine are usually preferred first-line where choice exists.
Breastfeeding: second-generation antihistamines pass into breast milk in tiny amounts and are considered compatible with breastfeeding. Loratadine and cetirizine have the most data.
Kinderen: Approved from age 6 months (syrup) in most markets; 5 mg tablet from age 6.
Who Should Not Take Xyzal?
- Known hypersensitivity to levocetirizine or other antihistamines in the same class
- Severe renal impairment without dose adjustment
- End-stage renal disease on haemodialysis (dose per nephrology guidance)
- Severe hepatic impairment — dose reduction recommended for some molecules
- Children below the age cutoff for the formulation
- Pregnancy / breastfeeding — use only under medical advice; loratadine and cetirizine are preferred where choice exists
Opslag
Store Xyzal below 25°C in a dry place, in the original blister. Keep out of reach of children.
Veelgestelde vragen
Is Xyzal the same as levocetirizine?
Yes — Xyzal contains the active ingredient levocetirizine. Bioequivalence to the originator brand (Xyzal (UCB, 2001 EU / 2007 US)) is required by regulatory authorities, so clinical effect is the same at the same dose.
What is the difference between Xyzal (levocetirizine) and Zyrtec (cetirizine)?
Cetirizine is a racemic mixture of two enantiomers; only the (R)-enantiomer binds the H1 receptor. Levocetirizine is that active enantiomer purified. Clinical effect is very similar, but 5 mg levocetirizine causes less sedation than 10 mg cetirizine. Either works; levocetirizine is a touch cleaner.
Will Xyzal make me drowsy?
Less sedating than its parent cetirizine at equivalent clinical potency — drowsiness rates in trials are about half those of cetirizine 10 mg. If you do feel drowsy, take your dose in the evening, or switch to fexofenadine (the least-sedating 2nd-generation antihistamine).
Is it safe to take Xyzal every day for months or years?
Yes — long-term daily use of 2nd-generation antihistamines is well-studied and safe for most adults. There is no tachyphylaxis (the effect does not fade), no cumulative organ toxicity, and no withdrawal syndrome. Chronic urticaria patients often take an antihistamine daily for years.
Can I take Xyzal with other allergy medications?
Yes, in most cases. Combining an oral antihistamine with an intranasal corticosteroid (e.g. mometasone, fluticasone) is the standard combination for moderate hay fever. Eye drops (olopatadine, ketotifen) can be added for eye symptoms. Avoid combining two oral antihistamines at the same time without medical advice.
How quickly does Xyzal work?
Onset is usually 30–60 minutes, with peak effect at 0.8–1 hour. For seasonal hay fever, starting 1–2 weeks before your usual trigger season gives the best control.
What happens if I take more than the recommended dose?
Single-dose overdoses of 2nd-generation antihistamines rarely cause serious harm at a few multiples of the standard dose, but can cause drowsiness, tachycardia, and (rarely) QT prolongation. Seek medical advice if more than 5× the standard dose has been taken, especially in children.
Where can I buy Xyzal online?
You can order Xyzal (5 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.
Related Allergy Medications
- Allegra — Fexofenadine (least-sedating antihistamine)
- Xyzal — Levocetirizine (cetirizine’s active enantiomer)
- Okacet — Cetirizine (generic Zyrtec)
- Lorfast Meltab — Loratadine orally dissolving
- Dazit — Desloratadine
- Meta Spray — Mometasone intranasal corticosteroid
- Arzep — Azelastine + Fluticasone nasal spray
- Browse all Hay Fever & Allergy Medications
Gerelateerde alternatieven
Andere producten in Chronische aandoeningen die klanten ook bekijken:
More options in Hay Fever/Allergies Treatment
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 5 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Xyzal
Vragen & antwoorden
Xyzal
Gerelateerde producten
Beoordelingen
Er zijn nog geen beoordelingen