Montek Plus
✅ Manages asthma
✅ Controls wheezing
✅ Reduces bronchoconstriction
✅ Eases breathing
✅ Prevents airway inflammation
Montek Plus contains Montelukast & Bambuterol.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Montek Plus?
Montek Plus bevat montelukast + levocetirizine, an oral preventer for asthma and allergic rhinitis. The combination delivers montelukast (a leukotriene receptor antagonist that blocks LTD4 mediator action) plus levocetirizine (a non-sedating second-generation H1 antihistamine). Used for allergy-driven asthma where rhinitis and bronchospasm coexist (the United Airways disease). Each tablet contains montelukast 10 mg + levocetirizine 5 mg, geproduceerd door Sun Pharma. Taken once daily in the evening.
Important — neuropsychiatric warning: the FDA added a black-box warning in 2020 noting reports of mood changes, sleep disturbance, anxiety, depression, and (rarely) suicidal ideation with montelukast. Discuss any new mood symptoms with your prescriber.
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What Is Montek Plus?
Montek Plus is a combination of montelukast (LTRA) and levocetirizine (antihistamine) manufactured by Sun Pharma at WHO-GMP certified facilities. Available as 4 mg, 5 mg, and 10 mg tablets — strengths chosen by age and indication.
How Does Montek Plus Work?
- Montelukast selectively antagonises the CysLT1 receptor — preventing LTD4-mediated bronchoconstriction, eosinophil recruitment, mucus hypersecretion, and microvascular leak.
- Levocetirizine (active R-isomer of cetirizine) blocks histamine H1 receptors with high selectivity — controls itching, sneezing, runny nose, and mild bronchospasm without significant sedation.
- Combined the two molecules cover the leukotriene and histamine arms of the allergy cascade, giving more complete control of allergic asthma and rhinitis than either alone.
Toepassingen en Indicaties
- Persistent asthma — add-on preventer in patients not controlled by ICS alone (alternative to LABA or LAMA add-on)
- Exercise-induced asthma — particularly effective; taken 2 hours before exercise
- Aspirin-exacerbated respiratory disease (AERD) — leukotrienes are central to this phenotype
- Allergic rhinitis — both seasonal (hay fever) and perennial
- Allergic asthma with concomitant rhinitis — the combo addresses both compartments simultaneously
- Chronic urticaria — montelukast as adjunct to high-dose antihistamine
Montek Plus Dosage
| Patient | Dosering | Frequentie |
|---|---|---|
| Adults & children >15 yr | 1 tablet | Once daily in the evening |
| Children 6–14 yr (Montek Plus 5 strength) | 1 tablet (5 mg + 2.5 mg) | Once daily in the evening |
Side Effects of Montek Plus
- Hoofdpijn
- Mild abdominal pain or nausea
- Sleep disturbance (vivid dreams, insomnia)
- Mood changes — irritability, anxiety, depression (FDA black-box warning, 2020)
- Mild drowsiness from levocetirizine in some users (less than first-generation antihistamines)
- Rash
Serious — stop and seek help:
- Severe allergic reaction / angio-oedema
- Suicidal ideation or severe depression — STOP and seek urgent psychiatric review
- Churg-Strauss syndrome (eosinophilic vasculitis) — rare; suspect in ICS-tapering patients with new vasculitic features (rash, neuropathy, eosinophilia)
- Hepatitis (rare)
Waarschuwingen en voorzorgsmaatregelen
- Black-box warning — neuropsychiatric events. If new mood changes, anxiety, sleep disturbance, agitation, depression, or suicidal thoughts occur, stop Montek Plus and contact your prescriber.
- Not a rescue medication. Do not use in acute asthma attacks — onset is too slow.
- Continue ICS if previously prescribed; montelukast does not replace inhaled corticosteroids.
- Leverfunctiestoornis: use cautiously in moderate-to-severe disease.
- Zwangerschap en borstvoeding: reasonable safety data; use when benefits outweigh risks.
- Children may show increased risk of behavioural changes — counsel parents to monitor mood.
Contra-indicaties
- Hypersensitivity to montelukast, levocetirizine, or excipients
- Severe hepatic impairment — relative
- Severe renal impairment — levocetirizine accumulates
Geneesmiddelinteracties
| Interacting drug | Effect | Wat te doen |
|---|---|---|
| Phenobarbital, phenytoin, rifampicin | Induce CYP enzymes — reduce montelukast levels | Monitor asthma control |
| Gemfibrozil | Inhibits CYP2C8 — increases montelukast levels | Voorzichtig gebruiken |
| Warfarine | Theoretical INR change reported in case reports | Monitor INR after starting/stopping |
Opslag
- Store below 25°C in a cool, dry place away from direct sunlight.
- Keep in original packaging until use to protect from moisture and light.
- Do not use after the expiry date printed on the strip.
- Keep out of reach of children.
Gerelateerde alternatieven op MedsBase
- Asthalin Inhaler — salbutamol reliever
- Budecort Inhaler — budesonide ICS preventer
- Foracort Inhaler — budesonide + formoterol ICS-LABA
- Tiova Inhaler — tiotropium LAMA for COPD
- Montair — montelukast LTRA tablet
Veelgestelde vragen
When should I take montelukast?
Once daily in the evening, with or without food. Evening dosing matches the typical overnight rise in leukotriene mediators and gives best protection against early-morning symptoms.
How long until montelukast works?
Some symptom relief within 24–48 hours. Full effect on asthma exacerbation rate develops over 4–8 weeks.
Should I worry about the FDA black-box warning?
The 2020 FDA black-box warning highlighted reports of mood changes, sleep disturbance, anxiety, depression, and rarely suicidal ideation — particularly in children. The absolute risk is low but real. Watch for any new mood symptoms in yourself or your child; stop the drug and contact your prescriber if they appear.
Can montelukast replace my inhaler?
No — montelukast is an add-on preventer. It does not replace inhaled corticosteroids (Budecort, Beclate, Foracort, Seretide). Continue ICS as prescribed.
Is montelukast a rescue medication?
No — onset is too slow. Use a SABA (Asthalin, Levolin) for acute attacks.
Can children take montelukast?
Yes from 6 months of age in age-appropriate strengths (4 mg granules, 4 mg or 5 mg chewable, 10 mg tablet). Counsel parents to monitor mood and behaviour.
Is montelukast safe in pregnancy?
Reasonable observational data; use when benefits outweigh risks, particularly in patients whose asthma is well-controlled on it.
Does montelukast help allergic rhinitis?
Yes — montelukast is licensed for both asthma and allergic rhinitis. Particularly useful when both coexist (United Airways disease).
Should I stop montelukast if I feel better?
No — continue daily for as long as your prescriber advises. Stopping leads to gradual return of symptoms over days-to-weeks.
When is the Montek Plus combination used?
When asthma and allergic rhinitis coexist (the United Airways disease). The fixed-dose combination simplifies the regimen — one tablet covers both leukotriene and histamine arms of the allergy cascade.
Will Montek Plus make me drowsy?
Levocetirizine is a non-sedating second-generation antihistamine — drowsiness is uncommon (about 5–7% in trials, less than cetirizine). The drowsiness, if any, is usually mild.
Gerelateerde alternatieven
Andere producten in Chronische aandoeningen die klanten ook bekijken:
More options in Asthma/COPD Treatment
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 10+10 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Montek Plus
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