Reactin SR
✅ Sustained pain relief
✅ Extended anti-inflammatory action
✅ Reduces swelling
✅ Manages chronic pain
✅ Enhanced joint mobility
Reactin SR contains Diclofenac.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Reactin SR?
Reactin SR is een diclofenac 100 mg sustained-release tablet, a once-daily form of one of the most widely used oral NSAIDs. It is indicated for chronic inflammatory conditions — osteoarthritis, rheumatoid arthritis, ankylosing spondylitis — and for moderate to severe musculoskeletal pain where steady 24-hour cover is required. Usual adult dose is one 100 mg SR tablet once daily with food. Diclofenac has higher cardiovascular risk than ibuprofen — use at the lowest effective dose for the shortest reasonable time.
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Reactin SR 100 mg is a sustained-release diclofenac tablet formulated to deliver a steady plasma level over 24 hours from a single daily dose. This is useful for chronic inflammatory pain where round-the-clock anti-inflammatory cover is needed and adherence with multi-dose regimens is difficult.
At 100 mg, Reactin SR is the stronger sibling of the 75 mg SR diclofenac tablets (Voveran SR). It is typically chosen when:
- The patient needs a higher total daily diclofenac dose
- Simple once-daily dosing is clinically preferable
- Smooth plasma levels are required to avoid peak-related GI symptoms
What Is Reactin SR Used For?
- Osteoarthritis — long-term symptom control
- Rheumatoid arthritis
- Ankylosing spondylitis
- Chronic musculoskeletal pain with inflammatory component
- Post-surgical pain (step-down from higher-intensity analgesia)
- Low back pain with a marked inflammatory component (short to intermediate courses)
How Does Diclofenac Work?
Diclofenac is a non-selective NSAID. It blocks the cyclooxygenase (COX-1 and COX-2) enzymes that convert arachidonic acid to prostaglandins — the molecules that drive pain, swelling, and fever at sites of tissue injury. Less prostaglandin means less pain and inflammation. Because COX-1-derived prostaglandins also protect the stomach lining and regulate kidney blood flow, the same mechanism that gives NSAIDs their benefit also accounts for their main side effects.
Reactin SR Dosing
- Adults: one 100 mg SR tablet once daily with food
- Maximum: 150 mg/day of diclofenac from all sources
- Duration: short-course for acute conditions (10–14 days); longer in chronic inflammatory arthritis with regular review
- Ouderen: use with caution; consider the 75 mg SR or 50 mg IR form instead
- Nierfunctiestoornis: avoid if CrCl < 30 mL/min
- Leverfunctiestoornis: avoid in severe impairment
Swallow the SR tablet whole with water, with or after food. Do not crush, split, or chew — this destroys the sustained-release matrix and converts a 24-hour dose into an immediate burst, greatly increasing GI and cardiovascular risk.
Take at a consistent time each day (morning with breakfast works for most patients).
GI safety. Every oral NSAID — including Reactin SR — carries real risk of gastritis, peptic ulcer, and upper-GI bleeding. Risk is highest in patients over 65, those with prior ulcer disease, and anyone also on low-dose aspirin, corticosteroids, SSRIs, or anticoagulants. Take Reactin SR with food, at the lowest effective dose for the shortest reasonable time, and ask your doctor about a proton pump inhibitor (omeprazole, pantoprazole) for courses over 2–4 weeks.
Who Should Not Take Reactin SR?
- Known hypersensitivity to diclofenac or any NSAID
- Active or recurrent peptic ulcer or GI bleed
- Aspirin- or NSAID-induced asthma, urticaria, or angioedema
- Severe heart failure (NYHA IV)
- Established ischaemic heart disease, peripheral arterial disease, cerebrovascular disease (use an alternative NSAID)
- Recent CABG surgery
- Ernstige leverfunctiestoornis
- Severe renal impairment (CrCl < 30 mL/min)
- Third trimester of pregnancy
Cardiovascular and renal safety
All non-aspirin NSAIDs carry some increase in heart attack, stroke, and heart-failure risk — particularly diclofenac and COX-2 selectives. They can also raise blood pressure and reduce kidney function, especially in elderly patients and in anyone combining an NSAID with an ACE inhibitor/ARB plus a diuretic. Use the lowest effective dose for the shortest duration, and discuss a long course with your doctor if you have cardiovascular or kidney risk factors.
Bijwerkingen
- Vaak voorkomend: dyspepsia, nausea, abdominal pain, headache, dizziness, ankle swelling, rash, diarrhoea or constipation
- Minder vaak voorkomend: peptic ulcer, GI bleeding, hypertension, elevated liver enzymes, tinnitus, reduced kidney function, heart failure aggravation
- Zeldzaam: myocardial infarction, stroke, severe hepatotoxicity, Stevens-Johnson syndrome, aseptic meningitis, anaphylaxis
Stop Reactin SR and seek urgent medical care for: blood in stools or vomit, severe abdominal pain, yellowing of skin or eyes, chest pain, sudden-onset weakness or slurred speech, a widespread or blistering rash, or reduced urine output.
Bestellen & Levering
MedsBase offers worldwide shipping on every order. Orders are dispatched in discreet packaging and arrive in branded manufacturer packs. If your preferred pack size is out of stock, contact customer support for an ETA.
Medisch disclaimer. The information on this page is provided for general education only. It is not a substitute for advice from your own doctor or pharmacist. Talk to a qualified healthcare professional before starting, stopping, or changing therapy, especially if you have a history of ulcer disease, heart disease, kidney disease, asthma, liver disease, or are pregnant.
Veelgestelde vragen
What is Reactin SR used for?
Reactin SR (diclofenac 100 mg sustained-release) is used for chronic inflammatory conditions — osteoarthritis, rheumatoid arthritis, ankylosing spondylitis — and for chronic musculoskeletal pain where 24-hour anti-inflammatory cover is required.
How is Reactin SR different from Reactin 50 mg?
Same molecule (diclofenac). Reactin 50 mg is immediate release, dosed 2–3 times a day — suited to acute short courses. Reactin SR is 100 mg sustained release, dosed once a day — suited to chronic inflammatory conditions where simple once-daily dosing is preferred.
How is Reactin SR 100 mg different from Voveran SR 75 mg?
Both are sustained-release diclofenac. Reactin SR is the stronger 100 mg once-daily preparation; Voveran SR is a 75 mg preparation, usually dosed twice daily. Choice depends on total daily dose needed and patient preference.
Should I take Reactin SR with food?
Yes — always. Take with or immediately after food to reduce gastric irritation.
Can I split or crush the Reactin SR tablet?
No. The sustained-release matrix must stay intact. Crushing releases the full 100 mg at once, causing a rapid peak and much higher GI and cardiovascular risk.
How long does Reactin SR take to work?
Pain relief usually begins within 1–2 hours of the first dose. Steady-state anti-inflammatory effect builds over 3–7 days of daily use.
Can I take Reactin SR long-term?
Yes, for chronic inflammatory arthritis, at the lowest effective dose and with regular review of blood pressure, kidney function, and liver enzymes. A proton pump inhibitor (omeprazole, pantoprazole) is usually co-prescribed for GI protection.
Can I take Reactin SR with paracetamol?
Yes. The combination is safe and commonly used for stronger pain relief via complementary mechanisms.
Can I take Reactin SR with another NSAID like ibuprofen?
No. Never combine two NSAIDs. This adds GI bleed and renal injury risk without additional pain-relief benefit.
Can I drink alcohol while on Reactin SR?
Light drinking is usually tolerated. Regular or heavy drinking sharply raises GI bleed risk — avoid during treatment.
Is Reactin SR safe in pregnancy?
Avoid after 20 weeks; contraindicated in the third trimester. Use in early pregnancy only on specialist advice.
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| Sterkte | 100 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Reactin SR
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Reactin SR
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