Trazonil

✅ Eases depression symptoms
✅ Enhances sleep quality
✅ Alleviates anxiety
✅ Manages PTSD
✅ Reduces side effects

Trazonil contains Trazodone Hydrochloride.

SKU: N/A Categorie: Categorieoverzicht, Chronische aandoeningen, Behandeling van situationele angst Tag: Trazodone, Trazonil

✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026

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Sterkte

25 mg
50 mg
100 mg

Hoeveelheid

30 tablet/ten
60 Tablet/s
90 tabletten
180 Tablet/s

Wissen

⚡ Quick Answer — What is Trazonil?

Trazonil bevat trazodone hydrochloride (50 mg / 100 mg) from a WHO-GMP certified manufacturer (Intas Pharmaceuticals) — a SARI antidepressant whose primary modern use is insomnia at low dose (25–100 mg at bedtime) rather than depression. Mechanism: 5-HT_2A antagonism plus weak SRI plus alpha-1 antagonism plus H₁ antagonism — the 5-HT_2A/H₁/alpha-1 combination drives sedation. Antidepressant doses (150–400 mg/day) are uncommon today — SSRIs and SNRIs largely replaced trazodone for MDD. Off-label insomnia is its dominant use. Important warnings: priapism (rare, 1 in 1,000–10,000 — emergency if > 4 h), orthostatic hypotension (alpha-1), QT prolongation at high doses. Very safe in overdose compared to TCAs.

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Important — this is not a situational-anxiety medication. Trazonil is a serotonin antagonist and reuptake inhibitor (SARI), prescribed and titrated over weeks for major depressive disorder (MDD); off-label widely used at low dose for chronic insomnia. It is niet the right drug for acute, performance-related anxiety (flying, public speaking, exams) — for those use cases beta-blockers (propranolol), benzodiazepines, or hydroxyzine are clinically appropriate. If you do not have a diagnosed mood, anxiety, or psychiatric disorder, do not start this medication.

FDA black-box warning — suicidality. All antidepressants carry an FDA black-box warning for increased risk of suicidal thinking and behaviour in children, adolescents, and young adults under 25, particularly during the first weeks of treatment or after dose changes. Family members and prescribers should monitor closely for worsening mood, agitation, or suicidal ideation in this age group.

What Is Trazonil?

Trazonil is an oral tablet of trazodone hydrochloride (50 mg / 100 mg) manufactured by Intas Pharmaceuticals. Trazodone (US brand Desyrel) is a serotonin antagonist and reuptake inhibitor (SARI) introduced in 1981. It blocks 5-HT_2A receptors potently, weakly inhibits the serotonin transporter, and antagonises alpha-1 adrenergic and H₁ histamine receptors. The combination is heavily sedating — which is why trazodone has become predominantly an off-label hypnotic rather than an antidepressant in modern practice.

Indicaties

Major depressive disorder — on-label, but uncommon today (SSRIs / SNRIs are first-line)
Insomnia (off-label, low-dose) — the most common modern use; 25–100 mg at bedtime
Off-label adjuncts: SSRI-induced insomnia, anxiety with insomnia, agitation in dementia (used with caution)

Dosering

Indicatie	Start	Typical	Maximum	Opmerkingen
Insomnia (off-label)	25–50 mg at bedtime	50–100 mg at bedtime	150 mg at bedtime	Most commonly used dose range; effective hypnotic without significant antidepressant action
MDD (on-label)	50–75 mg/day in divided doses	150–400 mg/day	600 mg/day inpatient	Daytime divided doses for antidepressant effect; sedation often prohibitive
Elderly insomnia	25 mg at bedtime	25–50 mg at bedtime	100 mg	Caution — orthostasis and falls
Leverfunctiestoornis	Reduce by 25–50%	—	—	Slower titration

Bijwerkingen

Side-effect profile

Frequentie	Effect	Opmerkingen
Vaak voorkomend	Sedation, drowsiness	The point of off-label hypnotic use; problematic for daytime dosing
Vaak voorkomend	Orthostatische hypotensie, duizeligheid	Alpha-1 blockade — falls risk in elderly
Vaak voorkomend	Dry mouth, blurred vision	Mild anticholinergic
Vaak voorkomend	Misselijkheid, braken	— verbetert de verdraagzaamheid van metformine.
Less common	Headache, nasal congestion	Alpha-1 blockade
Less common	Weight gain (modest)	Less than mirtazapine or paroxetine
Zeldzaam	Priapism (1 in 1,000–10,000)	Persistent erection > 4 h is a urological emergency — mechanism is alpha-1 blockade interfering with detumescence; men should be counselled and report immediately
Zeldzaam	QT-verlenging	Dose-related; caution with other QT-prolonging drugs
Zeldzaam	Serotonin syndrome	See interactions

Geneesmiddelinteracties

Absolute contraindications: MAOIs (14-day washout).

Additive sedation: alcohol, benzodiazepines, opioids, antihistamines, sedating antipsychotics — main interaction concern in older adults.

QT-verlenging: caution with citalopram (high dose), ondansetron, methadone, fluoroquinolones.

CYP3A4 substrate: levels rise with strong inhibitors (ketoconazole, ritonavir, clarithromycin) — reduce dose or avoid.

Antihypertensiva: additive orthostasis with alpha-blockers, doxazosin, prazosin, terazosin.

Why Trazodone for Insomnia?

Trazodone has become the most-prescribed off-label sleep medication in many countries despite very thin formal sleep-disorder evidence. The reasons are pragmatic:

Heavy sedation at low dose (25–100 mg)
No physiological dependence or rebound insomnia (unlike benzodiazepines / Z-drugs)
No DEA scheduling
Low overdose toxicity
Generic and inexpensive
Useful when SSRI-induced insomnia complicates depression treatment

Limitations: orthostatic falls (especially in older adults), priapism risk in men, and limited objective data on sleep-architecture preservation. Daytime grogginess can persist with low-dose 100 mg use.

Veelgestelde vragen

How long does Trazonil take to work for sleep?

Sedation begins within 1–2 hours of taking the dose. Take 30 minutes before intended bedtime.

Will Trazonil help with depression at low dose?

No — antidepressant effect requires 150–400 mg/day in divided doses. Bedtime 25–100 mg is purely a hypnotic dose.

Is Trazonil safer than zolpidem (Ambien) or benzodiazepines for sleep?

Different risk profile. Trazodone has no dependence potential and far lower overdose risk, but more orthostasis, falls, priapism (rare), and daytime grogginess. The right choice depends on patient age, fall risk, sex (priapism in men), and history of substance use.

What is priapism and how worried should I be?

Priapism is a persistent erection unrelieved by ejaculation, usually painful, lasting more than 4 hours. It is a urological emergency — without prompt treatment, permanent erectile dysfunction can result. Trazodone-related priapism is rare (1 in 1,000–10,000) but real. Men starting trazodone should be told to seek emergency care for any erection lasting more than 4 hours.

Can I drink alcohol on Trazonil?

Avoid — additive sedation and orthostasis. Combining trazodone with alcohol significantly increases sedation and fall risk.

Does Trazonil cause sexual dysfunction?

Less than SSRIs. Mechanism is different — the 5-HT_2A blockade does not cause SSRI-style sexual side effects. Priapism in men is the rare specific concern.

Can I stop Trazonil abruptly?

Better to taper, but discontinuation syndrome is much milder than SSRIs / SNRIs. Tapering over 1–2 weeks is usually sufficient.

Is Trazonil safe in pregnancy?

Limited data — not first-line. Discuss individually with the prescriber.

Can Trazonil cause weight gain?

Modest weight gain over months — less than mirtazapine, paroxetine, or olanzapine. Not a major concern at hypnotic doses.

How should Trazonil be stored?

Store at 15–30 °C in the original blister packaging away from moisture and sunlight. Keep out of reach of children — trazodone is much safer in overdose than TCAs but still medically significant.

Medische disclaimer: Information on this page is intended for adults using prescribed psychiatric medication and is not a substitute for individualised medical care. Antidepressants, antipsychotics, and related medications can interact with other drugs, alcohol, and pre-existing conditions. Discuss any new medication, dose change, or planned discontinuation with a qualified prescriber. If you experience suicidal thoughts, mania, severe akathisia, signs of serotonin syndrome (high fever, confusion, muscle rigidity, rapid heart rate), or neuroleptic malignant syndrome, seek emergency care immediately.