Reglan

📦 Každá objednávka je pokryta naší Zárukou opětovného odeslání — pokud vaše zásilka nedorazí do 20 pracovních dnů, přeposíláme ji.

Proč objednávat z MedsBase

Naše generické léky pocházejí od výrobců certifikovaných WHO-GMP a jsou expedovány po celém světě v diskrétním, nenápadném balení – na vnější straně balíku není uveden název léku. Platby kartou jsou směrovány prostřednictvím regulovaného procesoru (popisky na výpisu zahrnují regulovaného procesora plateb kartou – nikdy “MedsBase” nebo název léku). Přijímáme také kryptoměny a bankovní převody SEPA. Každá objednávka je zajištěna naší politikou přeposlání.

Proč objednávat z MedsBase

Reglan is supplied from a výrobce certifikovaného WHO-GMP. Every order ships discreetly worldwide and is covered by our Zárukou opětovného odeslání — if it does not arrive within 20 business days, we reship at no cost. Metoclopramide remains a first-line agent for several niche indications (migraine-associated nausea, post-operative ileus prevention, lactation enhancement) where its central D2 effect is helpful.

Mechanismus účinku

Metoclopramide blocks dopamine D2 receptors centrally (in the chemoreceptor trigger zone, the nigrostriatum, and the tuberoinfundibular system) and peripherally (gut). At higher doses it also blocks 5-HT3 and stimulates 5-HT4 receptors in the gut, which contributes to its prokinetic effect. CNS penetration distinguishes it from domperidone and explains both its higher antiemetic potency and its extrapyramidal side-effect profile.

Indikace

• Nausea and vomiting (chemotherapy-induced, post-operative, migraine-associated)
• Diabetic and idiopathic gastroparesis (12-week max under EMA)
• Aspiration prevention pre-anaesthesia (rapid-sequence induction adjunct)
• Adjunct in radiology to speed barium transit
• Off-label: galactagogue

Dávka

Adults: 10 mg up to three times daily, 30 minutes before meals and at bedtime if needed. Maximum cumulative duration: 5 days for nausea/vomiting (FDA), 12 weeks for gastroparesis (EMA, specialist). CrCl < 60: reduce dose 50 percent. Hepatic impairment: reduce dose. Children: avoid < 1 year; restricted use in > 1 year for chemo-induced or post-op nausea, weight-based.

Vedlejší účinky

• Common: drowsiness, restlessness, fatigue, diarrhoea
• Extrapyramidal: acute dystonia, akathisia, parkinsonism, tardive dyskinesia (BLACK-BOX)
• Hyperprolactinaemia: galactorrhoea, gynaecomastia, menstrual disturbance
• Rare: neuroleptic malignant syndrome, seizures, methaemoglobinaemia (G6PD-deficient infants)
• Cardiac: bradycardia and hypotension after rapid IV push

Interakce léků

• Anticholinergics, opioids: oppose the prokinetic effect.
• Other dopamine antagonists (haloperidol, risperidone, prochlorperazine): additive extrapyramidal risk — avoid stacking.
• MAO inhibitors: hypertensive crisis — avoid.
• SSRIs, SNRIs: serotonin syndrome (rare).
• Levodopa: each blocks the other's effect — do not co-prescribe.
• Digoxin: gastric-emptying acceleration may reduce digoxin absorption.

Často kladené dotazy

How is Reglan different from domperidone?

Both block D2 receptors. Metoclopramide crosses the blood-brain barrier and is more potent as an antiemetic but causes extrapyramidal side effects (FDA black-box). Domperidone is peripheral-only with minimal EPS but has a QT-prolongation signal.

What does the FDA black-box mean for me?

Use the lowest dose for the shortest time. Tell the prescriber immediately about any involuntary tongue, jaw, lip, or limb movements — these may be early tardive dyskinesia and the drug must be stopped.

Can I take it for travel sickness?

There are better-tolerated alternatives (cinnarizine, hyoscine, antihistamines). Metoclopramide is not first-line for motion sickness because it does not act on the vestibular system.

Is it safe in pregnancy?

Category B in the US. Used in pregnancy for nausea/vomiting and is the second-line after pyridoxine-doxylamine when first-line fails. Discuss with obstetric prescriber.

Can I drive on this?

Drowsiness is common, especially in the first few days. Do not drive or operate machinery until you know how it affects you.

What if I develop a stiff neck or strange jaw movements?

Stop the drug and seek medical help. Acute dystonia is treated with IV anticholinergic (procyclidine or benztropine) and is fully reversible.

Why do I have leaky breasts on this medication?

Metoclopramide raises prolactin via pituitary D2 blockade. The effect is reversible on discontinuation.

Can it interact with my Parkinson’s drugs?

Yes — metoclopramide blocks central D2 receptors and can dramatically worsen Parkinson’s motor symptoms. Avoid in Parkinson’s disease.

Skladování

Below 25°C in a dry place. Keep out of reach of children.

Co když vynechám dávku?

Take it before the next meal, then continue. Do not double up.

Other Gastro Health Medications

• Dompewal — Domperidone (peripheral D2 antagonist)
• Stemetil — Prochlorperazine (antiemetic)
• Doxinate — Doxylamine + B6 (NVP first-line)
• Omez D — Omeprazole + Domperidone SR
• GR8-OD — Pantoprazole + Domperidone SR
• Browse all Gastro Health Medications

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