CJC-1295 with DAC

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What Is CJC-1295 with DAC?

CJC-1295 is a synthetic 30-amino-acid analog of growth-hormone-releasing hormone (GHRH), specifically a modified form of the biologically-active GHRH (1-29) fragment. The “with DAC” suffix refers to a proprietary Drug Affinity Complex (DAC) — a maleimidopropionic acid residue attached to lysine-30 — which forms a covalent bond with serum albumin cysteine-34 in vivo.

That albumin tether is the key innovation. Native GHRH has a plasma half-life measured in minutes (rapid DPP-IV degradation); CJC-1295 with DAC circulates bound to albumin for approximately 7 ημέρες, enabling weekly or twice-weekly research dosing while sustaining GH/IGF-1 elevation between injections. This is a fundamentally different pharmacokinetic profile from the “without DAC” version (sometimes called Mod GRF 1-29) which retains native GHRH’s short half-life. Developed by ConjuChem, CJC-1295 is for laboratory research use only and is not intended for human or veterinary diagnosis or therapy. For mechanism, research context, and stacking protocols, see our Ipamorelin & CJC-1295 research guide.

Mechanism of Action — Extended-Release GHRH Agonism

CJC-1295 with DAC acts through two sequential mechanisms:

• GHRH receptor agonism — the peptide binds GHRH receptors on pituitary somatotropes, stimulating growth-hormone synthesis and release. This is the same receptor and downstream pathway as endogenous GHRH.
• Albumin-tethered extended half-life — the DAC lysine side chain forms a Michael-addition covalent bond with the free thiol on albumin cysteine-34. Albumin’s ~20-day half-life carries the peptide with it, protecting CJC-1295 from rapid DPP-IV cleavage and extending functional plasma half-life to ~7 days. The result is sustained exposure of pituitary cells to GHRH signal rather than the short pulses seen with native GHRH.
• Hepatic IGF-1 amplification — elevated and sustained GH exposure drives hepatic IGF-1 production. The extended-release kinetics means IGF-1 levels remain elevated throughout the dosing interval rather than spiking and falling within hours.

The practical research consequence: a single weekly injection maintains elevated GH and IGF-1 tone across the full interval, eliminating the need for multiple daily injections. When stacked with a GHRP such as ipamorelin (which acts on the parallel ghrelin-receptor pathway), the combination produces larger GH pulses than either alone — the canonical GH-axis research stack.

Published Research Applications

CJC-1295 with DAC is used in laboratory research contexts that investigate:

• Hepatic IGF-1 elevation — sustained plasma IGF-1 response via extended-release GHRH signal (Teichman et al., J Clin Endocrinol Metab 2006)
• Extended dosing protocols — weekly or twice-weekly research protocols made possible by the ~7-day half-life
• Body composition research — lean mass, fat mass, and body-composition research in GH-axis modulation studies
• Ipamorelin synergy research — the canonical “CJC-1295 + ipamorelin” research stack investigating GHRH + GHRP additive pharmacology
• Sleep architecture — slow-wave sleep and nocturnal GH-axis research in preclinical models
• Bone density research — osteoblast activity and bone mineral density research via GH/IGF-1 axis modulation
• Comparative GHRH research — side-by-side with sermorelin και tesamorelin (both GHRH analogs without DAC) to isolate the extended-half-life effect

For broader context on the GH-axis peptide landscape, see the research peptides catalog.

Available Strengths and Concentrations

MedsBase stocks CJC-1295 with DAC in the following lyophilized vial sizes. Each variation ships in 10-vial, 20-vial, or 30-vial pack formats:

Because CJC-1295 with DAC is typically dosed at 1–2 mg weekly (or 300–500 mcg twice-weekly), a single vial covers an extended research duration. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.

How It Compares — CJC-1295 with DAC vs Without DAC vs Ipamorelin

The three most-commonly-studied GH-axis peptides differ significantly in mechanism and dosing:

The full pharmacology comparison, stacking protocols, and when researchers select “with DAC” vs “without DAC” versions are covered in our Ipamorelin + CJC-1295 research guide.

Storage and Reconstitution

Before reconstitution: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.

Reconstitution procedure: inject bacteriostatic water down the side wall of the peptide vial per the dilution chart above. Swirl gently — do δεν shake — and allow 5–10 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless.

After reconstitution: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution — freeze-thaw cycles degrade peptide integrity.

Συχνές Ερωτήσεις

What is CJC-1295 with DAC used for in research?

CJC-1295 with DAC is used in laboratory research investigating extended-release GHRH signaling, hepatic IGF-1 elevation, body composition, GH-axis kinetics, sleep research, and synergistic stacking with GHRP peptides such as ipamorelin. It is δεν FDA-approved and is sold here strictly for laboratory research use only.

What does “with DAC” mean?

DAC stands for Drug Affinity Complex — a maleimidopropionic-acid residue attached to the peptide that binds covalently to cysteine-34 on serum albumin. The albumin tether extends plasma half-life from ~30 minutes (native GHRH) to approximately 7 days, enabling weekly research dosing.

What is the difference between CJC-1295 with DAC and without DAC?

The core peptide sequence is the same. The “with DAC” version has the albumin-binding maleimide attached, giving ~7-day half-life and weekly dosing. The “without DAC” version (also called Mod GRF 1-29) lacks the albumin tether, has ~30-minute half-life, and requires multiple daily doses. Both have their research use cases. See our CJC-1295 without DAC product page.

What is the typical CJC-1295 with DAC research dose?

Published preclinical protocols typically use 1–2 mg once weekly, or 300–500 mcg twice weekly. A 2 mg vial reconstituted with 2.0 mL bacteriostatic water yields 1.0 mg/mL — 30 ticks on a U-100 syringe delivers 300 mcg.

Is CJC-1295 FDA approved?

No. CJC-1295 was originally developed by ConjuChem but never received FDA or EMA regulatory approval for any indication. All CJC-1295 sold by research-use-only suppliers is for laboratory investigation, not therapy.

How should CJC-1295 with DAC be stored?

Lyophilized vials: refrigerated at 2–8 °C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2–8 °C, use within 30 days. Do not freeze reconstituted solution.

How do I reconstitute CJC-1295 with DAC?

Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do δεν shake the vial.

Should I stack CJC-1295 with DAC with ipamorelin in research?

The CJC-1295 + ipamorelin pairing is the canonical GH-axis research stack. The two peptides bind different receptors (GHRH-R vs ghrelin-R) on the same pituitary cells, and their effects on GH release are synergistic — combined use produces larger GH pulses than either alone. See our stack research guide for protocols.

What strengths does MedsBase stock?

MedsBase carries CJC-1295 with DAC in 2 mg and 5 mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.

Does CJC-1295 with DAC cause side effects in research?

Published preclinical research has reported a reasonable safety profile at typical research doses. The most commonly reported finding is transient injection-site redness. Long-term human safety data are not available because human trials were discontinued. Some studies have identified a risk of “GH bleed” (sustained elevation producing IGF-1 saturation) with very high doses.

What is the half-life of CJC-1295 With DAC?

CJC-1295 with DAC has a half-life of approximately 6–8 days, achieved through the Drug Affinity Complex (DAC) technology — a maleimidopropionic acid group that forms a covalent bond with circulating serum albumin. This dramatically extends the dosing interval; most research protocols use once-weekly or twice-weekly administration.

What does DAC mean in CJC-1295 with DAC?

DAC stands for Drug Affinity Complex — a reactive group attached to the peptide that, once injected, binds covalently to circulating albumin (half-life ~19 days), dramatically extending the peptide’s active period. The result is a continuous, non-pulsatile GH release pattern (often called a “GH bleed”), which differs from the pulsatile secretion produced by CJC-1295 without DAC or by Sermorelin.

Can I order CJC-1295 with DAC for international shipping?

Yes. MedsBase ships CJC-1295 with DAC worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.

Other Peptides for Recovery and Performance Research

• BPC-157 — Body Protection Compound — tendon, ligament, gut recovery research
• TB-500 — Thymosin Beta-4 fragment — soft tissue and vascular recovery research
• Ipamorelin — Selective ghrelin agonist — clean GH pulse without cortisol/prolactin
• GHK-Cu — Copper peptide — skin and connective tissue regeneration research
• IGF-1 LR3 — Long-R3 IGF-1 analog — anabolic / regenerative research

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