L-Glutathione 250mg
✅ Supports detoxification process
✅ Promotes healthier skin
✅ Enhances immune function
✅ Reduces oxidative stress
✅ Improves cellular repair
Contains L-Glutathione 250mg (reduced) (Free form).
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
Snelle antwoord
L-Glutathione 250mg is reduced glutathione (GSH) in free form — the body’s master intracellular antioxidant. Each capsule supplies 250 mg. Typical adult use is 250–500 mg once or twice daily for antioxidant support, hepatic detox adjunct, and skin pigmentation interest. Taken with food. Not a substitute for prescription liver therapy in diagnosed hepatic disease.
📦 Elke bestelling is gedekt door onze Reshipment Assurance Policy — als uw pakket niet binnen 20 werkdagen arriveert, sturen wij het opnieuw.
What L-Glutathione is
Glutathione is a tripeptide of glutamate, cysteine and glycine, synthesised by every cell in the body. It is the dominant intracellular antioxidant — the GSH/GSSG redox pair maintains cellular reducing capacity, regenerates vitamin C and vitamin E from their oxidised forms, and serves as a co-substrate for glutathione peroxidases (which detoxify peroxides) and glutathione S-transferases (which conjugate xenobiotics for biliary excretion).
The 250 mg capsule supplies reduced (GSH) free-form L-glutathione, not oxidised glutathione (GSSG) and not glutathione precursors (NAC, glycine). This matters because oral GSH bioavailability has historically been controversial: gastric peptidases hydrolyse a fraction of the dose, but human pharmacokinetic studies (Allen 2011; Richie 2015) show that sustained 250–1,000 mg/day oral GSH measurably raises whole-blood GSH levels at 1–6 months.
Indications and supportive evidence
- Antioxidant support — general nutritional adjunct in oxidative stress states (intense training, smoking cessation, ageing).
- Hepatic detoxification adjunct — supports phase-II conjugation in mild-to-moderate steatosis, alcohol-related hepatic strain, paracetamol-induced subclinical liver irritation. Not a substitute for medical care in diagnosed liver disease.
- Skin pigmentation interest — oral glutathione is widely used in cosmetic dermatology for tyrosinase modulation and dyschromia. The clinical evidence is mixed (Sonthalia 2018 review): some studies show modest melanin-index reduction at 250–500 mg/day over 4–12 weeks; others show no consistent effect. Effect size is smaller and slower than topical hydroquinone or tretinoin.
- Adjunct in PCOS, insulin resistance and metabolic syndrome — small studies suggest improved insulin sensitivity markers; not a primary therapy.
Typical dosing
| Gebruik | Dosering | Duur |
|---|---|---|
| General antioxidant | 250 mg once or twice daily | Ongoing |
| Hepatic adjunct | 500 mg once or twice daily | 3–6 months, then reassess |
| Skin / pigmentation interest | 500 mg/day with vitamin C 500–1,000 mg | Min 4–12 weeks for any visible change |
Take with a meal containing fat for absorption. Vitamin C 500–1,000 mg/day commonly co-prescribed because ascorbate regenerates GSH from GSSG and is consumed in parallel.
What this is NOT
This product is oral glutathione. Black-market intravenous glutathione for skin lightening has caused fatal Stevens-Johnson syndrome, toxic epidermal necrolysis, kidney injury and lead-contamination outbreaks (Philippines 2011, Korea 2014). The Philippine FDA and US FDA have repeatedly warned against IV glutathione for non-medical use. We do not supply or recommend it.
Bijwerkingen
Oral glutathione is well tolerated. Reported effects: mild bloating, abdominal cramping, occasional loose stool. Rare allergic reactions. Long-term oral use up to 1 g/day for 6 months has not produced safety signals.
Interactions and special populations
- Pregnancy / breastfeeding — not enough data; avoid unless advised by a clinician.
- Asthma — case reports of nebulised (not oral) glutathione triggering bronchospasm in sulphite-sensitive asthmatics. Oral capsules do not contain free sulphite.
- Chemotherapy — the GSH/GSSG axis interacts with many cytotoxic agents (cisplatin, doxorubicin). Discuss with oncology before adding any antioxidant.
Opslag
Store below 30 °C in a dry place, original blister/bottle. Glutathione oxidises with humidity exposure — keep desiccant intact.
Waarom bestellen bij MedsBase
L-Glutathione 250mg is supplied through a WHO-GMP certified manufacturer with full COA documentation. We ship worldwide in plain, discreet packaging, and every order is covered by our Reshipment Assurance Policy. Your statement descriptor when paying by card shows the regulated payment processor (a regulated card-payment processor), never "MedsBase" or any medication name.
Veelgestelde vragen
Does oral L-glutathione actually raise blood glutathione levels?
Yes, in sustained dosing. Whole-blood GSH rises measurably after 1–6 months at 250–1,000 mg/day in human studies (Richie 2015 EJCN). Single doses produce only transient peaks. Daily dosing is what works.
How long until I see skin-tone changes if I am using it for pigmentation?
Plan for at least 4–12 weeks. Effect size is modest and gradual. Combine with daily SPF 50, vitamin C 500–1,000 mg, and treat any underlying cause (UV exposure, hormonal melasma, post-inflammatory hyperpigmentation). Topical agents (hydroquinone, azelaic, tretinoin) act faster and more strongly.
Is intravenous glutathione for skin lightening safe?
No. IV glutathione for cosmetic skin lightening is not approved by the FDA, EMA, or Philippine FDA. Reported harms include Stevens-Johnson syndrome, toxic epidermal necrolysis, acute kidney injury, thyroid dysfunction and lead contamination from unregulated compounding. We strongly advise against it.
How does L-glutathione differ from N-acetylcysteine (NAC)?
NAC is a precursor — the body converts it to cysteine and then to glutathione. NAC is cheaper, has stronger evidence for paracetamol overdose (intravenous), and is better studied. Direct GSH supplementation bypasses the conversion step but has historically had lower oral bioavailability. Both are used; in practice, daily oral GSH 250–500 mg or NAC 600 mg is the common range.
Can I take it with vitamin C?
Yes — they are commonly combined. Vitamin C regenerates oxidised glutathione (GSSG) back to active GSH and is depleted in parallel. 500–1,000 mg/day vitamin C is typical alongside.
Will glutathione cause any laboratory abnormalities?
No clinically significant abnormalities at oral 250–500 mg/day. Some labs note a small drop in plasma cysteine and slight rise in whole-blood GSH on long-term use.
Can I take it during pregnancy?
Insufficient safety data. Avoid in pregnancy and breastfeeding unless your clinician has specifically advised it.
Do I need to take it on an empty stomach?
Take with a meal containing some fat. Stomach acid degrades a fraction of any oral peptide, but absorption is more reliable with food.
How does this product compare to liposomal glutathione?
Liposomal GSH is encapsulated in phospholipid spheres for improved gastrointestinal absorption, with some PK studies showing higher whole-blood GSH at lower doses. The 250 mg standard capsule format works at higher daily totals (500–1,000 mg) and at a fraction of the price; the choice is mostly cost vs convenience.
Can I open the capsule and mix into food?
Yes — the contents are an off-white powder. Mix into yogurt, smoothies or juice. Take immediately after mixing because dissolved GSH oxidises within minutes.
Other Antioxidant & Skin Care Products
- Andere Vitamines & Mineralen
- Melanorm Cream (hydroquinone 2%) — direct topical depigmentation
- Skinlite Cream (Kligman triple, HQ 2%) — multi-modal
- Skinshine Cream (Kligman triple, HQ 4%) — stronger triple
- Eflora Cream (eflornithine) — facial-hair adjunct
- Celin (vitamin C 500 mg) — antioxidant pair for GSH regeneration
Medische Disclaimer
This information is provided for educational purposes only and is not a substitute for medical advice. Always consult a qualified healthcare professional before starting, changing, or stopping any medication.
Meer opties in Vitaminen en Mineralen
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 250 mg |
|---|---|
| Hoeveelheid | 1 Bottle, 2 Bottles, 3 Bottles, 6 Bottles |
L-Glutathione 250mg
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L-Glutathione 250mg
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