Ciplactin
✅ Promotes appetite
✅ Supports weight gain
✅ Alleviates allergies
✅ Relieves itching
✅ Manages migraine
Ciplactin contains Cyproheptadine.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Ciplactin?
Ciplactin is een merk van cyproheptadine hydrochloride (4 mg), a first-generation (sedating) oral antihistamine of the piperidine class (also a serotonin 5-HT2 antagonist). Used for allergic rhinitis, urticaria (hives), itchy skin, insect-bite reactions, and mild allergic reactions. Onset: 30–60 minutes; duration: 4–6 hours — so doses are typically spread 2–3 times daily. A dual H1 + 5-HT2 antagonist. Strongest anti-itch effect of the 1st-gen antihistamines, but with prominent sedation, appetite stimulation, and weight gain. Widely used in India, Latin America, and Asia — less common in Western countries, where 2nd-generation antihistamines dominate. Causes drowsiness in most users — do not drive or operate machinery after a dose until you know how it affects you. Avoid in narrow-angle glaucoma, bladder-outflow obstruction, severe asthma attack, and in older adults where alternatives exist. Not a treatment for anaphylaxis — severe allergic reactions need adrenaline.
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What Is Ciplactin?
Ciplactin is an oral antihistamine containing cyproheptadine hydrochloride (4 mg), manufactured by Cipla Inc. Supplied in packs of 30, 60, 90 or 180 tablets. Originator brand: Periactin (Merck, 1961).
cyproheptadine hydrochloride belongs to the first-generation H1 antihistamine class — the original antihistamines developed in the 1940s and 50s. They are effective but, unlike newer agents, cross the blood-brain barrier readily, which causes sedation and anticholinergic side effects. First-generation antihistamines are still useful for acute allergic episodes, short-term night-time itch, and specialised uses (motion sickness, certain migraine protocols, appetite stimulation).
What Is Ciplactin Used For?
Allergic rhinitis, urticaria, itchy skin, serotonin syndrome (antidote use), cyproheptadine is also widely used off-label as an appetite stimulant in poor-appetite states and failure-to-thrive. Historically used in migraine prevention, carcinoid syndrome (for diarrhoea/flushing), and SSRI-induced sexual dysfunction.
How Does Ciplactin Work?
cyproheptadine hydrochloride blocks histamine H1 receptors throughout the body. Histamine is released from mast cells and basophils during allergic reactions and causes the classic symptoms: sneezing, runny nose, itchy eyes, vasodilation, urticaria, bronchoconstriction, and mucus secretion. Blocking H1 receptors interrupts these effects.
Unlike newer (2nd-generation) antihistamines, first-generation agents readily cross the blood-brain barrier and bind central H1 receptors — producing sedation. They also have appreciable affinity for muscarinic acetylcholine receptors, causing classic anticholinergic effects (dry mouth, urinary hesitancy, blurred vision, constipation). Cyproheptadine additionally blocks serotonin 5-HT2 receptors, giving it unique uses in serotonin syndrome, carcinoid syndrome, and appetite stimulation.
Dosering en toediening
Dosering: Adults: 4 mg 3 times daily (usual range 4–20 mg/day; max 32 mg/day). Children 7–14: 4 mg 2–3 times daily. Children 2–6: 2 mg 2–3 times daily.
- Onset of action: 30–60 minutes.
- Duration: 4–6 hours — this is why 2–3 doses per day are needed, compared with once-daily dosing for 2nd-generation antihistamines.
- Take with or without food; food may reduce early drowsiness slightly.
- A bedtime dose is useful when drowsiness and night-time itch are issues; daytime doses may impair concentration.
- Miss a dose — take as soon as you remember unless the next dose is due; do not double up.
- Not intended for long-term daily use when 2nd-generation alternatives are available.
Bijwerkingen
Sedation: Cyproheptadine is markedly sedating and commonly causes drowsiness. Most patients experience sedation at standard doses; tolerance may develop partially over 1–2 weeks.
Anticholinergic: Moderate — dry mouth, blurred vision, urinary hesitancy, constipation. Avoid in narrow-angle glaucoma, bladder-outflow obstruction, and elderly with falls risk.
Gewicht: Significant appetite stimulation and weight gain are characteristic effects — cyproheptadine is routinely prescribed off-label as a weight-gain aid in children with anorexia or failure to thrive. Can be a desired or undesired effect depending on context.
Other common side effects:
- Hoofdpijn, duizeligheid
- Impaired concentration, slowed reaction time
- Photosensitivity (occasional)
- Thickened bronchial secretions (relevant in asthma)
Zeldzaam maar belangrijk:
- Paradoxical CNS stimulation in children (hyperactivity, irritability, rarely seizures at high doses)
- Urinary retention in men with prostate enlargement
- Precipitation of narrow-angle glaucoma
- Falls in older adults (from sedation + anticholinergic delirium risk)
- Hypersensitivity reactions
Geneesmiddelinteracties
- Alcohol, benzodiazepines, opioids, hypnotics — additive CNS depression. Avoid or use with great caution.
- Tricyclic antidepressants, MAO inhibitors — additive anticholinergic effect; MAOIs may prolong and intensify antihistamine effects — avoid within 14 days.
- Other anticholinergic drugs (oxybutynin, scopolamine, atropine) — additive dry mouth, urinary retention, constipation, cognitive blunting.
- SSRIs / SNRIs — cyproheptadine is sometimes used to treat SSRI-induced sexual dysfunction but may reduce SSRI antidepressant effect; use under medical advice.
- Metoclopramide, prochlorperazine — additive sedation and extrapyramidal effects.
Who Should Not Take Ciplactin?
- Newborns and premature infants
- Nursing mothers — first-generation antihistamines pass into breast milk and may cause irritability or feeding difficulty in the infant; 2nd-generation agents are preferred if treatment is needed
- Acute asthma attack — anticholinergic effect thickens secretions
- Narrow-angle glaucoma
- Bladder-outflow obstruction or symptomatic prostatic hypertrophy
- Peptic ulcer with pyloric obstruction
- Use of monoamine oxidase inhibitors (MAOIs) within 14 days
- Known hypersensitivity to cyproheptadine hydrochloride or similar antihistamines
- Older adults — avoid where 2nd-generation alternatives exist (falls, confusion, urinary retention risks)
Use in Pregnancy and Children
Zwangerschap: first-generation antihistamines have been used for decades with a reasonable safety record, but 2nd-generation agents (loratadine, cetirizine) are preferred first-line. Discuss with your obstetrician before starting.
Borstvoeding: 1st-generation antihistamines pass into breast milk and may sedate the infant. They can also reduce milk supply. Prefer loratadine or cetirizine when treatment is needed in a breastfeeding mother.
Kinderen: age cutoffs in the Dosage section. Paradoxical excitation can occur in young children.
Opslag
Store Ciplactin below 25°C in a dry place, in the original blister. Keep out of reach of children.
Veelgestelde vragen
Is Ciplactin the same as cyproheptadine hydrochloride?
Yes — Ciplactin contains the active ingredient cyproheptadine hydrochloride. Bioequivalence to the originator brand (Periactin (Merck, 1961)) is required by regulatory authorities.
Is cyproheptadine used for weight gain?
Yes — cyproheptadine is one of the most commonly prescribed off-label appetite stimulants in children with failure-to-thrive, poor appetite, or cachexia, and sometimes in adults. Typical dose is 2–4 mg 2–3 times daily; weight gain of 1–3 kg over 4–8 weeks is typical. It is not approved as a weight-gain agent in most countries, and the effect is driven by H1 blockade and serotonin antagonism in the hypothalamic appetite centre. Discuss with a doctor before using for this purpose.
How drowsy will Ciplactin make me?
Cyproheptadine is markedly sedating and commonly causes drowsiness. Most patients experience sedation at standard doses; tolerance may develop partially over 1–2 weeks. Plan your first dose for a time when you do not need to drive or operate machinery for at least 6–8 hours. Effect is dose-dependent; smaller split doses often cause less sedation than a single large dose.
Can I take Ciplactin every day?
First-generation antihistamines are generally not recommended for long-term daily use when 2nd-generation agents are available — the anticholinergic burden and sedation add up. For chronic hay fever or urticaria, switch to loratadine, cetirizine, or fexofenadine. Short courses are safe for acute episodes.
Can I drink alcohol with Ciplactin?
No. Alcohol and first-generation antihistamines both depress the central nervous system; combining them significantly increases drowsiness, impaired coordination, and risk of accidents.
Can I give Ciplactin to my child?
Age cutoffs differ by formulation — see the dosage section. Paradoxical excitation (irritability, hyperactivity, trouble sleeping) is a recognised reaction in young children; if it occurs, stop and consult a doctor. For routine allergies in children, cetirizine or loratadine are preferred first-line.
Where can I buy Ciplactin online?
You can order Ciplactin (4 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.
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| Sterkte | 4 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
Ciplactin
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