Ivrea Cream
✅ Treats skin parasites
✅ Topical application
✅ Eliminates mites
✅ Relieves scabies symptoms
✅ Soothes itching
Ivrea Cream bevat Ivermectine.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Ivrea Cream?
Ivrea Cream is een topical 1% ivermectin preparation in a 30 g tube. Its FDA-licensed use is papulopustular (inflammatory) rosacea, where it reduces the inflammation and redness driven by Demodex folliculorum skin mites. It is also used off-label for head lice and small-area scabies in some regions. Apply a pea-sized amount once daily to affected areas of clean, dry skin for up to 16 weeks. Generic equivalent of Galderma’s Soolantra®.
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Ivrea Cream is een topical ivermectin 1% w/w cream supplied in a 30 g tube. It is designed for once-daily application to the face to treat the inflammatory papules and pustules of rosacea, and is also used off-label for certain ectoparasite conditions.
Ivrea Cream contains the same active ingredient and strength as Galderma’s branded Soolantra® — a first-line topical therapy in current dermatology guidelines for papulopustular rosacea. By combining an antiparasitic en anti-inflammatory action on the skin’s surface, 1% ivermectin directly addresses the two mechanisms believed to drive rosacea-related lesions.
What Is Ivrea Cream?
Ivrea Cream delivers ivermectin 1% in a moisturising cream base suitable for the face. Topical ivermectin at this concentration has two relevant effects on the skin:
- Anti-parasitic — kills Demodex folliculorum mites that live in hair follicles, whose over-population is strongly associated with rosacea flares
- Ontstekingsremmend — directly modulates local inflammatory pathways in the skin, reducing the visible redness and papule formation independently of its mite-killing effect
Ivrea Cream is used for:
- Papulopustular rosacea (inflammatory rosacea) — the primary and licensed indication
- Demodex-associated facial dermatitis / demodicosis — where mite over-population drives itching, redness, or blepharitis
- Off-label head lice (pediculosis capitis) — a single 10-minute application to dry hair and scalp
- Off-label small-area scabies — oral ivermectin or 5% permethrin cream is usually preferred for whole-body treatment; topical 1% ivermectin may be used in limited lesions or adjunctively
Ivrea Cream is not the same as high-strength scabies creams. For widespread scabies infestation, permethrin 5% or oral ivermectin (e.g. Iverjohn, Iverheal) remain first-line.
How Does Ivrea Cream Work?
Ivermectin is a macrocyclic lactone derived originally from the soil bacterium Streptomyces avermitilis. Applied topically at 1%:
- It selectively binds glutamate-gated chloride channels in arthropod and nematode nerve cells, causing hyperpolarisation, paralysis, and death of the target organism
- In rosacea skin, it kills Demodex mites resident in the sebaceous ducts — reducing the inflammatory stimulus the mites create
- Independently, ivermectin has a direct anti-inflammatory effect: it suppresses LPS-induced inflammatory cytokine production, down-regulates toll-like receptor signalling, and reduces neutrophil activity in the skin
- Clinical response typically becomes visible within 4 weeks and peaks by 12–16 weken
In head lice, a single application is enough to paralyse both adult lice and newly-hatched nymphs — the cream remains in the hair long enough to kill the nymphs that emerge after treatment.
Toepassingen en Indicaties
- Papulopustular rosacea — first-line topical, included in global dermatology guidelines (AAD, BAD, German S2k)
- Ocular rosacea with blepharitis — off-label adjunct
- Demodex folliculorum overgrowth — facial or eyelid-margin infestation
- Head lice (pediculosis capitis) — single application to scalp and hair
- Localised scabies lesions — off-label, usually alongside oral or whole-body topical therapy
Ivrea Cream Dosage and Administration
| Indicatie | Amount | Frequency / Duration |
|---|---|---|
| Papulopustular rosacea | Pea-sized amount per affected area (~5 small dots spread over the face) | Once daily for up to 16 weeks; can repeat 16-week courses |
| Ocular rosacea / blepharitis | Thin layer applied to eyelid margin (avoid eye) | Once daily for 4–8 weeks under ophthalmological supervision |
| Head lice | Enough to thoroughly coat dry hair and scalp | Single application left in place for 10 minutes, then rinse; repeat in 7–10 days if needed |
| Localised scabies (adjunct) | Thin layer to affected area | Once daily for 7 days — usually combined with oral ivermectin or permethrin |
| Kinderen | Not routinely recommended under 18 | Off-label paediatric use under dermatology guidance |
| Ouderen | Standaarddosering | Geen aanpassing nodig |
| Ernstige leverfunctiestoornis | Caution | Systemic absorption of topical ivermectin is minimal, so clinical risk is low |
How to Apply Ivrea Cream Properly
- Clean the affected skin with a mild, soap-free cleanser and pat dry. Do not apply to wet skin
- Dispense a pea-sized amount and divide it into 5 small dots across forehead, cheeks, chin, and nose
- Spread a thin, even layer — rub in gently until the cream disappears. Do not pile it on
- Avoid the eyes, lips, and mucous membranes
- Wash hands after application
- Allow several minutes to absorb before applying moisturisers, sunscreen, or makeup over it
- Continue nightly even if initial response is subtle — most benefit builds between weeks 4 and 16
- Do not combine with other topical rosacea treatments (e.g. metronidazole, azelaic acid) on the same day without medical advice
Side Effects of Ivrea Cream
Topical ivermectin is very well tolerated — systemic absorption is minimal so systemic side effects are rare.
| Ernst | Bijwerking |
|---|---|
| Vaak (≥1 op de 100) | Mild burning or stinging on application, dry skin, mild transient itching |
| Minder vaak | Skin irritation, contact dermatitis, worsening rosacea during the first 1–2 weeks (“initial flare”) |
| Zeldzaam | Allergic contact dermatitis, urticaria, photosensitivity |
Initial flare: some patients see a transient worsening of rosacea in the first 1–2 weeks as dying Demodex mites release inflammatory contents — this usually settles and is not a reason to stop treatment. If discomfort is marked, reduce to alternate-day application for the first 2 weeks and resume daily dosing afterward.
Waarschuwingen en voorzorgsmaatregelen
- Avoid eye contact. If accidental contact occurs, rinse with plenty of water
- Do not swallow. Oral ingestion of topical ivermectin is unlikely to cause serious harm at the quantities in a 30 g tube, but seek medical advice if ingestion is significant
- Zwangerschap. Limited human data — use only if the potential benefit justifies the risk. Topical absorption is minimal
- Borstvoeding. Small amounts of oral ivermectin pass into breast milk; topical exposure is expected to be far lower. Avoid applying to the breast area while breastfeeding
- Children under 18. Not routinely recommended — paediatric use only under dermatology supervision
- Sun exposure. Rosacea is worsened by UV — daily broad-spectrum sunscreen (SPF 30+) alongside Ivrea Cream improves long-term outcomes
- Triggers. Continue avoiding rosacea triggers (alcohol, spicy food, temperature extremes, harsh skincare)
Contraindications — Who Should NOT Use Ivrea Cream
- Known hypersensitivity to ivermectin or any excipient
- Application to broken, weeping, or severely inflamed skin where another dermatitis is present
- Application to mucous membranes or directly into the eye
Geneesmiddelinteracties
Topical ivermectin has minimal systemic absorption, so clinically significant drug interactions are rare.
| Agent | Interactie |
|---|---|
| Other topical rosacea therapies (metronidazole gel, azelaic acid, brimonidine) | Do not apply at the same time of day; separate by 12 hours or alternate days |
| Retinoids (tretinoin, adapalene, tazarotene) | Can be combined if skin tolerates; start on alternate days and build up |
| Cosmetics and sunscreens | Apply after Ivrea Cream has absorbed — allow 5–10 minutes |
| Corticosteroid creams | Do not apply alongside topical steroids; they can trigger rebound rosacea |
Tell your doctor about all skincare products you use, including over-the-counter cleansers, exfoliants, and acid treatments — these can irritate rosacea-prone skin.
Wat te doen bij overdosering
Accidental swallowing of a small amount is unlikely to cause significant toxicity because topical formulations contain dilute active ingredient. In case of large-volume ingestion, contact your local poisons service or emergency department. Skin over-application can cause increased local irritation but not systemic toxicity.
Bewaaradvies
- Bewaren onder 30 °C op een droge plaats, uit direct zonlicht
- Do not freeze
- Recap the tube tightly after use
- Discard 6 months after first opening even if product remains
- Buiten bereik van kinderen en huisdieren houden
Gerelateerde alternatieven op MedsBase
Looking for related rosacea, Demodex, or parasite-treatment options?
- Metrogyl — metronidazole, an alternative topical rosacea treatment
- Iverjohn — oral ivermectin tablets for scabies and widespread demodicosis
- Iverheal — alternative oral ivermectin tablet brand
- Ivermectol — Sun Pharma oral ivermectin
- Browse all Lice & Scabies treatments →
Veelgestelde vragen
What is Ivrea Cream used for?
Ivrea Cream is a topical 1% ivermectin preparation. Its primary licensed indication is papulopustular rosacea, where it reduces inflammatory papules, pustules, and redness. It is also used off-label for head lice and localised scabies lesions.
How fast does Ivrea Cream work?
For rosacea, early improvement usually appears by 4 weeks, with peak effect at 12–16 weken. A transient “initial flare” in the first 1–2 weeks is common as Demodex mites die off — persist through this.
Is Ivrea Cream the same as Soolantra?
Yes in active ingredients and strength — both contain 1% ivermectin. Ivrea Cream is the generic equivalent of Galderma’s branded Soolantra®, at a fraction of the price.
Can Ivrea Cream treat scabies?
It can help with small, localised scabies lesions, but it is not the first-line therapy for widespread scabies. For whole-body scabies, permethrin 5% cream of oral ivermectin tablets (e.g. Iverjohn) are standard. Always treat household contacts at the same time and decontaminate bedding and clothing.
How much should I apply?
A pea-sized amount for the whole face. More is not better — excess cream increases irritation without improving response.
Can I use Ivrea Cream with other rosacea treatments?
Yes, but not at the same time. Many patients use Ivrea Cream at night and a different agent (e.g. brimonidine gel for redness, or azelaic acid) in the morning. Do niet combine with topical steroids — they trigger rebound rosacea.
Do I still need to avoid rosacea triggers?
Yes. Topical ivermectin treats inflammation but does not change underlying skin vascular reactivity. Continue to avoid triggers (alcohol, spicy food, hot drinks, heat, harsh cleansers) and use daily broad-spectrum sunscreen.
Is Ivrea Cream safe during pregnancy?
Topical absorption is minimal, but safety data in pregnancy is limited. Use only if clearly needed and discuss with your doctor. Avoid during breastfeeding on the breast area.
How long can I use Ivrea Cream?
Licensed treatment courses are up to 16 weeks. Repeat courses are common in rosacea, which is a chronic condition. Many patients use it long-term at reduced frequency (e.g. 2–3 nights weekly) as maintenance, under dermatology guidance.
Can I use Ivrea Cream for acne?
It is not licensed for acne vulgaris, which is a different condition driven by Cutibacterium acnes (voorheen P. acnes) rather than Demodex. If you have overlapping acne and rosacea, discuss a combined approach with a dermatologist.
What if my skin stings the first time?
Mild burning or stinging in the first few applications is common and usually settles. If strong or persistent, reduce to alternate-day application for 1–2 weeks, use a gentle moisturiser underneath, and rebuild tolerance. Stop if a true contact dermatitis develops (widespread rash, severe burning).
Waarom bestellen bij MedsBase
Choosing Ivrea Cream from MedsBase gives you:
- WHO-GMP gecertificeerd — sourced from inspected manufacturing facilities
- Discrete verpakking — plain envelope, no medication name or pharmacy branding visible
- Wereldwijde verzending met Reshipment Assurance — every order covered
- Geverifieerde klantbeoordelingen — 1,400+ reviews across the catalogue
- Multiple payment options — including a 10% discount when you pay with cryptocurrency
Patients already using Ivrea Cream (ivermectin 1% topical cream) for papulopustular rosacea who develop concurrent scalp pediculosis can stay within the same ivermectin platform by adding Ivrea Shampoo (ivermectine 1% shampoo), avoiding the need to introduce a chemically unrelated pediculicide.
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| Sterkte | 1% w/w 30 g |
|---|---|
| Hoeveelheid | 1 Tube/s, 2 Tube/s, 3 Tube/s, 6 Tube/s |
2 beoordeling voor Ivrea Cream
| 5 sterren | 50% | |
| 4 sterren | 50% | |
| 3 sterren | 0% | |
| 2 sterren | 0% | |
| 1 ster | 0% |
Ivrea Cream
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