Loratin
✅ Allergy relief
✅ Antihistamine action
✅ Itchy eyes alleviation
✅ Sneezing reduction
✅ Non-drowsy formula
Loratin contains Loratadine.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Loratin?
Loratin is een merk van loratadine (10 mg), a second-generation, non-sedating oral antihistamine gebruikt voor hay fever (allergic rhinitis), chronic idiopathic urticaria (hives), itchy skin, and allergic conjunctivitis. It blocks histamine H1 receptors in the peripheral tissues that drive allergy symptoms — sneezing, runny nose, itchy eyes, skin hives — without crossing the blood-brain barrier meaningfully, so it does not make most people drowsy. Onset: 1–3 hours; duration: 24 hours. Once-daily dosing. The most widely used OTC antihistamine worldwide; extremely low drowsiness profile but somewhat weaker anti-itch effect than cetirizine or levocetirizine. Safe for long-term daily use (months to years) in most adults. Common side effects: mild headache, dry mouth, fatigue. Avoid in known hypersensitivity; dose-reduce in significant renal impairment.
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What Is Loratin?
Loratin is an oral antihistamine containing loratadine (10 mg), supplied as tablets. Manufactured by WHO-GMP certified manufacturer, in packs of 30, 60, 90 or 180 tablets. Originator brand: Claritin (Bayer / Schering-Plough, 1993).
loratadine belongs to the second-generation (non-sedating) H1 antihistamine class — developed to keep the allergy-blocking effect of older drugs like diphenhydramine or pheniramine while removing the sedation, dry mouth, and cognitive impairment caused by their passage into the brain. Second-generation agents are the first-line oral antihistamines for allergic rhinitis and chronic urticaria in every major allergy guideline (ARIA, EAACI, AAAAI).
What Is Loratin Used For?
- Seasonal allergic rhinitis (hay fever) — sneezing, runny nose, itchy nose, itchy/watery eyes caused by pollens (tree, grass, weed)
- Perennial allergic rhinitis — year-round symptoms from dust mites, pet dander, mould
- Chronic idiopathic urticaria (hives) — recurring itchy welts lasting > 6 weeks
- Allergische conjunctivitis — itchy, watery, red eyes from allergens
- Mild allergic skin reactions — pruritus (itch), insect bite reactions, mild contact urticaria
It is niet a treatment for anaphylaxis (use adrenaline/epinephrine auto-injector), asthma (use inhaled corticosteroid + bronchodilator), or allergic food reactions beyond mild skin symptoms.
How Does Loratin Work?
When you are exposed to an allergen (pollen, dust, animal dander), mast cells and basophils in the skin and mucosa release histamine. Histamine binds H1 receptors and causes the classic allergy cascade: vasodilation, vascular leakage, itch, sneeze, increased mucus secretion, and smooth-muscle contraction.
loratadine is a selective inverse agonist at H1 receptors. It stabilises the receptor in its inactive state, reducing signalling even at baseline histamine levels. Key features of the second-generation class:
- Peripheral H1 selectivity — strong binding in nose, skin, conjunctiva; minimal binding in the brain
- Poor blood-brain barrier penetration — so little to no sedation
- Minimal anticholinergic activity — unlike 1st-gen agents, no dry mouth, urinary retention, or constipation at therapeutic doses
- No tachyphylaxis — effect does not fade over weeks of daily use (a common misconception)
Dosering en toediening
Standaard dosering: 10 mg once daily in adults and children aged 12+. Children 2–11 and <30 kg: 5 mg once daily. Can be taken with or without food.
- Onset of action: 1–3 hours.
- Peak effect: 8–12 hours.
- Duration: 24 hours — so once-daily dosing is sufficient for most patients.
- Dosis vergeten? Take it as soon as you remember unless your next dose is due within a few hours; do not double up.
- Seasonal use. Start 1–2 weeks before your usual pollen trigger season for best effect; continue daily through the season.
- Chronic urticaria. Guidelines allow up-dosing to 2–4× standard dose if symptoms are not controlled — done under medical supervision.
Bijwerkingen
Minimal sedation — among the least drowsy 2nd-generation antihistamines; sedation rates in large trials are similar to placebo at the 10 mg dose.
Common (< 5% in most trials):
- Mild headache
- Droge mond
- Vermoeidheid
- Nausea or abdominal discomfort
Minder vaak voorkomend:
- Dizziness, sleep disturbance
- QT-interval effects at supratherapeutic doses (exceedingly rare at standard doses; more relevant historically for the withdrawn agents terfenadine and astemizole, not for current second-generation antihistamines)
- Hypersensitivity reactions, rash
- Transient transaminase elevation
Geneesmiddelinteracties
- Alcohol and CNS depressants — additive drowsiness (minor for non-sedating agents; avoid high-dose combinations).
- Ketoconazole, erythromycin, clarithromycin, ritonavir — may modestly raise plasma levels of loratadine/desloratadine/ebastine via CYP3A4 inhibition. Clinical effect usually small.
- Fruit juice (grapefruit, orange, apple) — significantly reduces fexofenadine absorption (~30–40%). Take with water.
- Antacids containing aluminium/magnesium — reduce fexofenadine absorption; separate by 2 hours.
- Pimozide, QT-prolonging drugs — caution; avoid high-dose combinations.
Use in Pregnancy and Children
Zwangerschap: Loratadine is one of two first-line antihistamines in pregnancy (alongside cetirizine) in ACOG and ASCIA guidelines. Large cohort data show no excess risk of major birth defects.
Borstvoeding: second-generation antihistamines pass into breast milk in tiny amounts and are considered compatible with breastfeeding. Loratadine and cetirizine have the most data.
Kinderen: Approved from age 2 years (5 mg syrup); 10 mg tablet from age 12.
Who Should Not Take Loratin?
- Known hypersensitivity to loratadine or other antihistamines in the same class
- Severe renal impairment without dose adjustment
- End-stage renal disease on haemodialysis (dose per nephrology guidance)
- Severe hepatic impairment — dose reduction recommended for some molecules
- Children below the age cutoff for the formulation
- Pregnancy / breastfeeding — use only under medical advice; loratadine and cetirizine are preferred where choice exists
Opslag
Store Loratin below 25°C in a dry place, in the original blister. Keep out of reach of children.
Veelgestelde vragen
Is Loratin the same as loratadine?
Yes — Loratin contains the active ingredient loratadine. Bioequivalence to the originator brand (Claritin (Bayer / Schering-Plough, 1993)) is required by regulatory authorities, so clinical effect is the same at the same dose.
Loratadine vs cetirizine vs fexofenadine — which is best?
All three are effective for allergic rhinitis and chronic urticaria. Cetirizine is generally the most potent (best for itch/hives) but causes drowsiness in about 10% of users. Fexofenadine is the least sedating (zero BBB penetration). Loratadine sits between them — very non-drowsy but weaker than cetirizine for itchy skin. For hay fever, pick whichever suits; for hives/itch, cetirizine often works best; for people who need to drive/operate machinery, fexofenadine is safest.
Will Loratin make me drowsy?
Minimal sedation — among the least drowsy 2nd-generation antihistamines; sedation rates in large trials are similar to placebo at the 10 mg dose. If you do feel drowsy, take your dose in the evening, or switch to fexofenadine (the least-sedating 2nd-generation antihistamine).
Is it safe to take Loratin every day for months or years?
Yes — long-term daily use of 2nd-generation antihistamines is well-studied and safe for most adults. There is no tachyphylaxis (the effect does not fade), no cumulative organ toxicity, and no withdrawal syndrome. Chronic urticaria patients often take an antihistamine daily for years.
Can I take Loratin with other allergy medications?
Yes, in most cases. Combining an oral antihistamine with an intranasal corticosteroid (e.g. mometasone, fluticasone) is the standard combination for moderate hay fever. Eye drops (olopatadine, ketotifen) can be added for eye symptoms. Avoid combining two oral antihistamines at the same time without medical advice.
How quickly does Loratin work?
Onset is usually 1–3 hours, with peak effect at 8–12 hours. For seasonal hay fever, starting 1–2 weeks before your usual trigger season gives the best control.
What happens if I take more than the recommended dose?
Single-dose overdoses of 2nd-generation antihistamines rarely cause serious harm at a few multiples of the standard dose, but can cause drowsiness, tachycardia, and (rarely) QT prolongation. Seek medical advice if more than 5× the standard dose has been taken, especially in children.
Where can I buy Loratin online?
You can order Loratin (10 mg) from MedsBase in packs of 30, 60, 90 or 180 tablets. We ship worldwide with discreet packaging and genuine WHO-GMP certified manufacturer stock.
Related Allergy Medications
- Allegra — Fexofenadine (least-sedating antihistamine)
- Xyzal — Levocetirizine (cetirizine’s active enantiomer)
- Okacet — Cetirizine (generic Zyrtec)
- Lorfast Meltab — Loratadine orally dissolving
- Dazit — Desloratadine
- Meta Spray — Mometasone intranasal corticosteroid
- Arzep — Azelastine + Fluticasone nasal spray
- Browse all Hay Fever & Allergy Medications
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| Sterkte | 10 mg |
|---|---|
| Hoeveelheid | 30 Tabletten, 60 Tabletten, 90 Tabletten, 180 Tabletten |
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