Atlura
Atlura (Lurasidone 20/40/80 mg) — 5-HT7-active atypical for schizophrenia and bipolar depression. must be taken with food (≥350 kcal) or absorption halves.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Rychlá odpověď
Atlura (Lurasidone 20 / 40 / 80 mg) is an atypical antipsychotic for schizophrenia and bipolar depression. Must be taken with food (≥ 350 kcal) — fasting halves absorption and produces treatment failure. Metabolically among the cleanest atypicals.
📦 Každá objednávka je pokryta naší Zárukou opětovného odeslání — pokud vaše zásilka nedorazí do 20 pracovních dnů, přeposíláme ji.
Proč objednávat z MedsBase
Atlura at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Zárukou opětovného odeslání — 20pracovníchdenní lhůta pro doručení, nebo vám zásilku zdarma přepošleme — a opravňuje vás k účasti v našem věrnostním programu. Dodáváme do většiny zemí po celém světě.
What Atlura is and how it works
Atlura is a lurasidone tablet supplied by Healing Pharma. Available strengths: 20 / 40 / 80 mg. Lurasidone is a D2/5-HT2A antagonist with additional 5-HT7 antagonism (the 5-HT7 component is the basis for its bipolar-depression indication). It is one of the cleanest atypicals on metabolic markers — minimal weight gain, minimal lipid effect, minimal glucose effect.
Fasting bioavailability of lurasidone is approximately half the fed bioavailability. Patients who skip a meal or take the dose at a small snack reach inadequate plasma levels and frequently appear to “fail” therapy. Take with the largest meal of the day, every day, at the same time. A glass of milk or a small biscuit is not enough — aim for at least 350 kcal of mixed-macronutrient food.
Indikace a dávkování
| Indikace | Počáteční dávka | Cílová dávka | Maximální dávka |
|---|---|---|---|
| Schizophrenia (adult) | 40 mg OD with food | 40–80 mg OD | 160 mg |
| Schizophrenia (adolescent ≥ 13 y) | 40 mg OD with food | 40–80 mg OD | 80 mg |
| Bipolar depression (adult, monotherapy or adjunct) | 20 mg OD with food | 20–60 mg OD | 120 mg |
| Bipolar depression (paediatric ≥ 10 y) | 20 mg OD with food | 20–80 mg OD | 80 mg |
| Renal impairment (CrCl < 50) | 20 mg OD with food | up to 80 mg | 80 mg |
Důležité bezpečnostní aspekty
All atypical antipsychotics carry an FDA black-box warning for increased mortality (mostly cardiovascular and infectious) when used to treat behavioural disturbance in older adults with dementia. Atypicals are not approved for dementia-related psychosis or agitation. Use in this population is off-label, last-resort, time-limited, and requires explicit risk-benefit conversation.
Akathisia is common at higher doses. EPS (rigidity, tremor, dystonia) less common than first-generation antipsychotics but can occur. Manageable with dose reduction or anticholinergic adjunct.
Avoid concurrent strong CYP3A4 inhibitors (azoles, clarithromycin, ritonavir, grapefruit juice) — they raise lurasidone levels several-fold. Avoid strong inducers (rifampicin, carbamazepine, phenytoin, St John’s wort) — they reduce levels into the ineffective range.
All antidepressant-class indications carry the under-25 suicidality warning.
Časté nežádoucí účinky
- Somnolence and sedation — common; usually settles.
- Akathisia — dose-dependent.
- Nevolnost — first 1–2 weeks; mitigated by food (which is mandatory anyway).
- EPS — uncommon but possible.
- Přibývání na váze — modest, generally less than olanzapine/quetiapine.
- Prolactin — small dose-dependent rise.
- Významné absence: minimal effect on lipids, glucose, QT.
Interakce léků
- Silné inhibitory CYP3A4 — contraindicated.
- Silné induktory CYP3A4 — contraindicated.
- Moderate CYP3A4 inhibitors (diltiazem, verapamil, fluconazole, erythromycin) — halve lurasidone dose; max 40 mg.
- Other CNS depressants — additive sedation.
- Other antipsychotics — additive EPS, prolactin, NMS risk.
Těhotenství, kojení, pediatrie
Pregnancy: limited data; weigh against untreated illness. Breastfeeding: insufficient data; generally avoided. Paediatric: licensed from 13 (schizophrenia), 10 (bipolar depression).
Skladování
Skladujte při 15–30 °C v původním obalu.
Často kladené dotazy
Why does Atlura need to be taken with food?
Fasting absorption is approximately half of fed absorption. The food requirement is not optional — patients who take Atlura on an empty stomach often appear to fail therapy when in fact they are simply under-dosed. The minimum threshold for adequate absorption is approximately 350 kcal of mixed food (a normal meal, not a snack).
Why is Atlura preferred for bipolar depression?
Lurasidone has FDA approval for bipolar depression as monotherapy or adjunct (PREVAIL-2 trial) — one of only three atypicals with this indication (others are quetiapine and olanzapine-fluoxetine). The 5-HT7 antagonism is thought to underlie the antidepressant effect. Lurasidone is a metabolically cleaner choice than quetiapine or olanzapine for bipolar depression.
Will Atlura make me gain weight?
Less than olanzapine, clozapine, quetiapine, or risperidone — typically 1–2 kg over 6 months in monotherapy. One of the better metabolic profiles among atypicals.
How long until Atlura works?
Schizophrenia: positive symptoms typically improve over 2–4 weeks; full effect at 4–6 weeks. Bipolar depression: 2–6 weeks for full effect. Compliance with the food requirement matters — if response is poor, check that doses are being taken with adequate meals.
Can Atlura be combined with mood stabilisers?
Yes — lurasidone is FDA-approved as an adjunct to lithium or valproate in bipolar depression. Combination is common and well-tolerated.
What about driving on Atlura?
Sedation is dose-dependent. Most patients on stable doses drive normally; the first 1–2 weeks of titration can impair reaction time.
How is Atlura different from olanzapine?
Lurasidone has a substantially better metabolic profile (less weight gain, less glucose disturbance, less lipid disturbance) but a slightly higher rate of akathisia and somnolence. Olanzapine is more sedating and has stronger acute antipsychotic effect; lurasidone is preferred for long-term metabolic safety.
Can Atlura be stopped abruptly?
Generally taper over 1–2 weeks, although withdrawal is mild. The relapse risk in schizophrenia and bipolar disease is the main reason for caution — never stop without prescriber agreement.
Why is grapefruit juice a problem?
Grapefruit juice is a strong CYP3A4 inhibitor. Lurasidone is a CYP3A4 substrate; grapefruit raises levels several-fold, increasing sedation, akathisia, and EPS risk. Avoid grapefruit and grapefruit juice during Atlura therapy.
Does Atlura prolong the QT interval?
Less than ziprasidone, less than thioridazine. Lurasidone has a small QT signal but is generally regarded as one of the cleaner atypicals for QT. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.
Další léky na duševní zdraví
- Aripicon (Aripiprazole — D2 partial agonist)
- Olanzap (Olanzapine — robust antipsychotic)
- Risdone (Risperidone)
- Seroquit (Quetiapine — bipolar depression)
- Atlura (Lurasidone — metabolically clean)
Další možnosti v oblasti duševního zdraví a psychiatrických léků
Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 40 mg |
|---|---|
| Množství | 30 tablet/ks, 60 tablet/ks, 90 tablet/ks, 180 tablet/ks |
Atlura
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