Risdone
Risdone (Risperidone 1/2/3/4 mg) — atypical antipsychotic for schizophrenia, bipolar mania, autism irritability. strong D2 blockade — highest prolactin elevation of atypicals.
✓ Lékařsky ověřeno Morgan Ellis — Pharmacy Researcher · 8 years experience Last reviewed: May 2026
⚡ Rychlá odpověď
Risdone (Risperidone 1 / 2 / 3 / 4 mg) is an atypical antipsychotic for schizophrenia, bipolar mania, irritability in autism (paediatric and adolescent), and short-term aggression in dementia. Highest prolactin elevation of any atypical — relevant for fertility, menstrual function, and bone density.
📦 Každá objednávka je pokryta naší Zárukou opětovného odeslání — pokud vaše zásilka nedorazí do 20 pracovních dnů, přeposíláme ji.
Proč objednávat z MedsBase
Risdone at MedsBase is supplied directly from a WHO-GMP certified manufacturer in plain, discreet packaging. Every order is covered by our Zárukou opětovného odeslání — 20pracovníchdenní lhůta pro doručení, nebo vám zásilku zdarma přepošleme — a opravňuje vás k účasti v našem věrnostním programu. Dodáváme do většiny zemí po celém světě.
What Risdone is and how it works
Risdone is a risperidone tablet supplied by Sun Pharma. Available strengths: 1 / 2 / 3 / 4 mg. Risperidone is a strong D2 and 5-HT2A antagonist with α1-adrenergic and H1 antihistamine activity, but minimal anticholinergic effect. The strong D2 blockade explains both the strong antipsychotic effect and the high rate of EPS and prolactin elevation.
Indikace a dávkování
| Indikace | Počáteční dávka | Cílová dávka | Maximální dávka |
|---|---|---|---|
| Schizophrenia (adult) | 1–2 mg OD or BID | 4–6 mg/day | 16 mg |
| Schizophrenia (adolescent ≥ 13 y) | 0.5 mg OD | 3 mg/day | 6 mg |
| Bipolar mania | 2–3 mg OD | 2–6 mg/day | 6 mg |
| Autism irritability (paediatric ≥ 5 y) | 0.25–0.5 mg OD | 0.5–3 mg/day weight-based | 2.5–3 mg |
| Older adults / dementia (off-label, last-resort) | 0.25 mg OD | 0.5–1 mg/day | 2 mg |
Důležité bezpečnostní aspekty
All atypical antipsychotics carry an FDA black-box warning for increased mortality (mostly cardiovascular and infectious) when used to treat behavioural disturbance in older adults with dementia. Atypicals are not approved for dementia-related psychosis or agitation. Use in this population is off-label, last-resort, time-limited, and requires explicit risk-benefit conversation.
Risperidone produces marked, dose-dependent hyperprolactinaemia. Clinical consequences: amenorrhoea, galactorrhoea, anovulation, and reduced bone density in women; loss of libido, erectile dysfunction, and gynaecomastia in men; in long-term use, accelerated osteoporosis. Check prolactin if symptoms suggest hyperprolactinaemia. If hyperprolactinaemia is symptomatic, consider switching to aripiprazole (lowers prolactin) or quetiapine.
Above approximately 6 mg/day, risperidone increasingly behaves like a typical antipsychotic on EPS — rigidity, tremor, akathisia, dystonia. Tardive dyskinesia risk is real but lower than typicals. Stay below 6 mg/day where possible.
α1 antagonism — common at initiation, particularly in older adults. Titrate slowly.
Less than olanzapine but real — weight gain typically 2–4 kg over 6 months. Monitor weight, fasting glucose, fasting lipids at baseline, 12 weeks, then 6-monthly.
Časté nežádoucí účinky
- Hyperprolactinaemia and downstream effects — distinguishing feature.
- EPS / akathisia — dose-dependent.
- Sedation, somnolence — common but moderate.
- Weight gain — moderate.
- Orthostatic hypotension — common at initiation.
- Anxiety, insomnia — common.
- Sialorrhoea (drooling) — particularly in clozapine-experienced patients.
Interakce léků
- Strong CYP2D6 inhibitors (paroxetine, fluoxetine, bupropion, quinidine) — raise risperidone levels; halve dose.
- Strong CYP3A4 inducers (rifampicin, carbamazepine, phenytoin) — reduce levels; may need dose increase.
- Other QT-prolonging drugs — additive risk.
- Antihypertenziva — additive orthostasis.
- CNS depressants — additive sedation.
Těhotenství, kojení, pediatrie
Pregnancy: limited data; late-pregnancy exposure can produce neonatal EPS or withdrawal. Breastfeeding: passes into milk; usually requires monitoring. Paediatric: licensed from 5 (autism), 10 (bipolar), 13 (schizophrenia).
Skladování
Skladujte při 15–30 °C v původním obalu.
Často kladené dotazy
Why does Risdone cause amenorrhoea / breast effects / sexual dysfunction?
Risperidone has the strongest dopamine D2 blockade among atypicals, and the pituitary lactotroph is regulated by tonic dopamine inhibition. Block D2 in the pituitary, and prolactin rises — sometimes 5–10× normal. The downstream hormonal effects (amenorrhoea, galactorrhoea, sexual dysfunction, accelerated osteoporosis) are common. Switching to aripiprazole or quetiapine usually normalises prolactin within weeks.
How is Risdone different from olanzapine?
Risperidone has a stronger acute antipsychotic effect for many positive symptoms but produces more EPS and far more hyperprolactinaemia. Olanzapine is metabolically heavier but doesn’t affect prolactin much. Choice depends on patient priorities: avoid weight gain → risperidone; avoid prolactin/EPS → olanzapine or aripiprazole.
Will Risdone make me gain weight?
Yes — moderate, typically 2–4 kg over 6 months. Less than olanzapine or quetiapine, more than aripiprazole or lurasidone.
Can Risdone be used in children?
Yes — risperidone is one of the most-prescribed atypicals in paediatrics, particularly for autism-associated irritability (FDA approval from age 5) and bipolar disorder (from age 10). Long-term use in children carries growth and prolactin concerns; specialist supervision recommended.
How long until Risdone works?
Acute calming and reduced agitation within hours of the first oral dose. Antipsychotic effect on positive symptoms usually within 1–2 weeks; full effect at 4–6 weeks. Bipolar mania response within days.
What about the orodispersible form?
Risperidone is also available as an orodispersible MT formulation that dissolves on the tongue — useful in acute psychosis or dysphagia.
Are LAI versions available?
Yes — Risperdal Consta (biweekly), Perseris (monthly subcutaneous), and Uzedy (monthly or bimonthly) are the three depot risperidone formulations, used for adherence support. The oral form is the standard initiation and titration formulation.
What about driving on Risdone?
The first 1–2 weeks of titration can impair reaction time. Most patients on stable doses drive normally. Avoid alcohol and other CNS depressants when driving.
Can Risdone be stopped abruptly?
Taper over 2–4 weeks. The relapse risk in schizophrenia and bipolar disease is the main reason for caution.
Does Risdone prolong the QT interval?
Modest effect; less than ziprasidone or thioridazine. Pre-treatment ECG is not routinely required but is reasonable in patients with cardiac risk factors.
Další léky na duševní zdraví
- Aripicon (Aripiprazole — D2 partial agonist)
- Olanzap (Olanzapine — robust antipsychotic)
- Risdone (Risperidone)
- Seroquit (Quetiapine — bipolar depression)
- Atlura (Lurasidone — metabolically clean)
Další možnosti v oblasti duševního zdraví a psychiatrických léků
Řazeno podle nedávného objemu objednávek na MedsBase — co si ostatní zákazníci v této kategorii vybírají.
| Síla | 1 mg |
|---|---|
| Množství | 30 tablet/ks, 60 tablet/ks, 90 tablet/ks, 180 tablet/ks |
Risdone
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