Ivermectol
Ivermectol (ivermectin 12 mg, Sun Pharma) — oral antiparasitic tablet for scabies, strongyloidiasis, head lice, river blindness, and lymphatic filariasis. WHO essential medicine.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
⚡ Quick Answer — What is Ivermectol?
Ivermectol is een 12 mg oral ivermectin tablet gebruikt voor de behandeling van scabies, strongyloidiasis, onchocerciasis (river blindness), lymphatic filariasis, head lice, and selected worm infections. Manufactured by Sun Pharma, Ivermectol is clinically equivalent to Merck’s Stromectol®. De gebruikelijke dosering voor volwassenen is 200 µg/kg as a single oral dose, with a repeat at 7–14 days for scabies. Take on an empty stomach with water.
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Ivermectol is een oraal ivermectin 12 mg tablet used for a wide range of parasitic infections. Manufactured by Sun Pharma to pharmaceutical-grade standards, it contains the same active ingredient as Merck’s branded Stromectol® — at a fraction of the price.
Ivermectin is on the WHO Model-lijst van essentiële geneesmiddelen. Its discovery earned Satoshi Ōmura and William C. Campbell the 2015 Nobel Prize in Physiology or Medicine, and it has played a central role in eliminating river blindness and lymphatic filariasis across large parts of the tropical world.
What Is Ivermectol?
Ivermectol is the Sun Pharma brand of ivermectin — a macrocyclic lactone antiparasitic derived from Streptomyces avermitilis. It is active against a broad range of nematodes (roundworms) and ectoparasites (mites, lice) but has no meaningful activity against cestodes (tapeworms) or trematodes (flukes).
Ivermectol 12 mg tablets are commonly prescribed for:
- Scabies — including crusted (Norwegian) scabies and institutional outbreaks
- Strongyloidiasis (Strongyloides stercoralis) — a chronic intestinal worm found worldwide
- Onchocerciasis (river blindness) — mass drug administration in endemic regions
- Lymphatic filariasis (Wuchereria bancrofti, Brugia species) — in combination with albendazole or DEC
- Head lice (Pediculus humanus capitis) — for treatment-resistant cases
- Ascariasis and enterobiasis (roundworm and pinworm) — less common; albendazole is the standard first-line
For a deeper comparison of ivermectin versus albendazole — the two most commonly prescribed antiparasitics — see our comprehensive guide: Ivermectin vs Albendazole: Which to Choose?
How Does Ivermectol Work?
Ivermectin has a distinctive mechanism that explains its wide antiparasitic range and excellent mammalian safety:
- It binds glutamate-gated chloride channels present in the nerve and muscle cells of invertebrates (nematodes and arthropods)
- Binding opens these channels, letting chloride ions flow in and hyperpolarising the cell — paralysing the parasite
- At higher concentrations, it also potentiates GABA-gated chloride channels
- Mammals lack glutamate-gated chloride channels at relevant tissue levels, and ivermectin is actively pumped out of the mammalian CNS by the P-glycoprotein efflux pump — which is why therapeutic doses are so well tolerated in humans
- Ivermectin does not kill microfilariae (immature worms) directly — it paralyses them and temporarily suppresses the adult worms’ release of new microfilariae. This is why onchocerciasis treatment requires repeated annual doses over years
Peak plasma is reached about 4 hours after an oral dose. Half-life is roughly 18 hours. Absorption is higher on a full stomach (+2.5-fold), so some protocols (notably crusted scabies) specifically recommend taking with a fatty meal.
Toepassingen en Indicaties
- Classical scabies — single dose 200 µg/kg, repeated at day 7–14
- Crusted (Norwegian) scabies — multi-dose regimen (days 1, 2, 8, 9, 15) combined with topical permethrin or benzyl benzoate
- Strongyloidiasis — single dose 200 µg/kg; immunocompromised patients may need longer courses
- Onchocerciasis — single dose 150 µg/kg, repeated every 3–12 months depending on setting
- Lymphatic filariasis — combination with albendazole or diethylcarbamazine
- Head lice — single oral 200 µg/kg dose, repeated at day 7
- Gnathostomiasis, cutaneous larva migrans — less common indications
Ivermectol Dosage and Administration
Ivermectol dosing is weight-based at 200 µg/kg for most indications. The 12 mg tablet supplies the typical adult single dose for anyone 60 kg and over.
| Indicatie | Dosering | Schema |
|---|---|---|
| Scabies (classical) | 200 µg/kg | Single oral dose; repeat at day 7–14 |
| Crusted scabies | 200 µg/kg | Days 1, 2, 8, 9, 15 + topical permethrin/benzyl benzoate |
| Strongyloidiasis | 200 µg/kg | Single dose; repeat after 2 weeks in severe or immunocompromised cases |
| Onchocerciasis (river blindness) | 150 µg/kg | Single dose every 6–12 months |
| Lymphatic filariasis | 200 µg/kg + albendazole 400 mg | Annual single dose |
| Head lice | 200 µg/kg | Single dose; repeat at day 7 |
| Weight <15 kg / children under 5 | Niet aanbevolen | Safety data limited; topical alternatives preferred |
| Ouderen | Standard weight-based dose | Geen routinematige aanpassing |
| Renal / hepatic impairment | Standard dose, caution | No specific adjustment data; clinical judgement |
Weight-based dosing at 200 µg/kg (12 mg tablet)
| Body weight | Number of 12 mg tablets |
|---|---|
| 15–24 kg | Quarter tablet (3 mg) — use scored tablet / liquid formulation if available |
| 25–35 kg | Half tablet (6 mg) |
| 36–50 kg | Three-quarters tablet (9 mg) |
| 51–65 kg | 1 tablet (12 mg) |
| 66–79 kg | 1.25 tablets (15 mg) |
| 80–94 kg | 1.5 tablets (18 mg) |
| 95–110 kg | 1.75 tablets (21 mg) |
| >110 kg | 2 tablets (24 mg) |
How to Take Ivermectol Properly
- Swallow the tablet whole with a full glass of water
- For classical scabies and most worm infections, take on an lege maag (at least 1 hour before or 2 hours after food)
- Voor crusted scabies or onchocerciasis with heavy microfilarial load, take with a fatty meal to maximise absorption
- Treat all close household contacts simultaneously for scabies, even if asymptomatic — otherwise re-infestation is almost guaranteed
- Wash bedding, clothing, and towels in hot water ≥60 °C on the treatment day
- A second dose at 7–14 days is essential for scabies to kill newly-hatched mites from eggs surviving the first dose
- Post-scabies itch can persist for 2–4 weeks after successful treatment — this is an allergic response to retained mite debris, not a treatment failure
Side Effects of Ivermectol
Ivermectol is extraordinarily well tolerated at therapeutic doses. Side effects are usually mild and short-lived.
| Ernst | Bijwerking |
|---|---|
| Vaak (≥1 op de 100) | Mild nausea, abdominal discomfort, transient headache, dizziness, drowsiness, fatigue |
| Treatment-related reactions (onchocerciasis / filariasis) | Mazzotti reaction: fever, itch, rash, lymphadenopathy, muscle ache — caused by dying microfilariae releasing antigen, not by the drug itself |
| Minder vaak | Rash, elevated liver enzymes, orthostatic hypotension, tachycardia |
| Zeldzaam maar ernstig | Encephalopathy (almost exclusively in patients with heavy Loa loa co-infection), severe hypersensitivity reactions, Stevens-Johnson syndrome |
Zoek medische hulp if you develop fever with severe headache, confusion, swollen glands, extensive rash, or breathing difficulty — these may reflect Mazzotti reaction or, in African regions, serious Loa loa complications.
Waarschuwingen en voorzorgsmaatregelen
- Loa loa co-infection. In Central and West Africa, rare but severe neurological reactions have occurred in patients with high Loa loa microfilarial loads. Pre-treatment screening is recommended in endemic regions
- Zwangerschap. Animal reproductive toxicity at high doses; avoid in the first trimester. WHO considers mass drug administration for onchocerciasis acceptable from second trimester onward in endemic areas
- Borstvoeding. Small amounts pass into breast milk; considered compatible with breastfeeding in most settings
- Young children. Limited safety data below 15 kg or under age 5 — use topical alternatives where possible
- Household treatment in scabies. Treating the index case alone virtually guarantees re-infestation — all contacts and bedding/clothing must be treated simultaneously
- Post-scabies itch. Persistent itch for 2–4 weeks after treatment is normal and is not a sign of treatment failure. Symptomatic antihistamines or a short course of topical steroid can help
Contraindications — Who Should NOT Take Ivermectol
- Known hypersensitivity to ivermectin or any excipient
- First trimester of pregnancy (relative contraindication)
- Children under 15 kg body weight — use topical alternatives
- Severe hepatic impairment — use cautiously
- Patients with heavy Loa loa microfilarial load until screened
Geneesmiddelinteracties
| Geneesmiddel / Klasse | Interactie |
|---|---|
| Potent CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, clarithromycin) | Raise ivermectin plasma levels — clinically manageable but monitor for side effects |
| P-glycoprotein inhibitors (ciclosporin, verapamil, amiodarone, quinidine) | May increase CNS penetration of ivermectin — theoretical encephalopathy risk; use cautiously |
| Warfarine | Case reports of mild INR elevation — monitor INR if on anticoagulation |
| Albendazole | Commonly co-prescribed for filariasis and broad-spectrum deworming — no pharmacokinetic concern |
| Alcohol | No specific interaction but may increase ivermectin absorption; moderate |
Always share a full list of prescription and non-prescription medications, including herbal supplements, with your prescriber before starting Ivermectol.
Wat te doen bij overdosering
Acute ivermectin overdose can cause ataxia, sedation, mydriasis, hypotension, seizures, and coma — mainly in settings where CNS penetration is increased (P-glycoprotein inhibitors or infants). Management is supportive. No specific antidote. Contact your local poisons service urgently if a significant overdose is suspected.
Bewaaradvies
- Bewaren onder 30 °C op een droge plaats, uit direct zonlicht
- Bewaren in de originele blisterverpakking
- Buiten bereik van kinderen houden
- Niet gebruiken na de vervaldatum die op de verpakking staat vermeld
- Ongebruikte tabletten inleveren bij een apotheek met innameprogramma, indien beschikbaar
Gerelateerde alternatieven op MedsBase
Looking for related antiparasitic options?
- Iverjohn — ivermectin 6/12 mg, alternative brand
- Iverheal — Healing Pharma ivermectin 3/6/12 mg
- ABD 400 (Albendazole) — standard first-line for roundworm, pinworm, and most intestinal worms
- Wormentel — alternative albendazole brand
- Bandy-Plus — albendazole + ivermectin combination for broad-spectrum deworming
- Mebex — mebendazole, an alternative benzimidazole antiparasitic
- Guide: Ivermectin vs Albendazole — which to choose
- Browse all Parasitic Infection treatments →
Veelgestelde vragen
What is Ivermectol used for?
Ivermectol is an oral ivermectin 12 mg tablet used for scabies, strongyloidiasis, onchocerciasis (river blindness), lymphatic filariasis, head lice, and selected worm infections. It is one of the most widely used antiparasitics worldwide.
How much Ivermectol should I take?
The standard dose is 200 µg/kg. For a 60–65 kg adult, that is one 12 mg tablet. See the weight-based table above for exact dosing. For scabies, the dose is typically repeated at day 7–14.
How fast does Ivermectol work?
For scabies, itching usually starts easing in a few days and is largely resolved by 2–4 weeks. Residual itch is common and reflects immune response to dead-mite debris, not treatment failure. For head lice, a single dose typically resolves the infestation by day 7.
Ivermectin or albendazole — which should I use?
It depends on the parasite. Ivermectine is first-line for scabies, strongyloidiasis, onchocerciasis, and head lice. Albendazole is first-line for pinworm, roundworm, hookworm, tapeworm, and hydatid disease. For a full comparison see our Ivermectin vs Albendazole guide.
Should I take Ivermectol with food?
For classical scabies and most worm infections, take on an lege maag (1 hour before or 2 hours after food) — this is how clinical trials were dosed. For crusted scabies or heavy microfilarial burden, take with a fatty meal to increase absorption.
Do I need to treat my whole household for scabies?
Yes — all close household contacts must be treated simultaneously, even if they are asymptomatic. Scabies has an asymptomatic incubation of 2–6 weeks, so untreated contacts will re-infest everyone. Wash bedding, clothing, and towels in hot water the same day.
Is post-scabies itch normal?
Yes — intense itch persisting 2–4 weeks after successful treatment is expected. It reflects the immune system’s allergic response to retained mite debris. Use antihistamines and a short course of topical steroid for symptom relief. Do not repeat ivermectin unless new burrows appear.
Is Ivermectol safe during pregnancy?
Use in the first trimester should be avoided. WHO considers mass drug administration for onchocerciasis acceptable from the second trimester in endemic regions. Discuss individual risk with a doctor.
Does Ivermectol treat tapeworms?
No. Ivermectin is ineffective against cestodes (tapeworms) and trematodes (flukes). Tapeworm treatment uses praziquantel or albendazole.
Does Ivermectol treat COVID-19?
Nee. Large, high-quality randomised trials (TOGETHER, ACTIV-6, PRINCIPLE) have shown no meaningful benefit of ivermectin in COVID-19. The FDA, WHO, and EMA all recommend against its use for COVID-19 outside of clinical trials.
What is the difference between Ivermectol and Iverjohn?
Both contain ivermectin at the same strength. Ivermectol is the Sun Pharma brand; Iverjohn is an alternative brand. Clinically equivalent at equivalent doses — use what is stocked or what your prescriber recommends.
Users wanting both ivermectin and fenbendazole in one order can switch to our Ivermectine & Fenbendazol Combinatiepakket — bundles both molecules at a combined price, useful for multi-pet households and broad-spectrum protocols.
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Andere producten in Algemene gezondheid die klanten ook bekijken:
📚 Meer informatie: Buy Ivermectin for Humans Online (2026): Dosage, Safety & Where to Order
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| Sterkte | 12 mg |
|---|---|
| Hoeveelheid | 10 Tablet/s, 20 Tablet/s, 30 Tablet/s, 60 Tablet/s |
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