KPV (Lysine-Proline-Valine)

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What Is KPV?

KPV is the three-letter one-letter-code shorthand for the Lys-Pro-Val tripeptide — the C-terminal three amino acids (positions 11–13) of alpha-melanocyte stimulating hormone (α-MSH). In the 1980s–1990s, multiple research groups noticed that the full α-MSH molecule produced two functionally separable effects: the well-known N-terminal MC-receptor pigmentation/arousal activity, and a C-terminal anti-inflammatory activity. When the C-terminal KPV tripeptide was synthesised and tested in isolation, it reproduced the anti-inflammatory effects without the pigmentation side-effects.

Molecular weight approximately 342.4 Da. KPV is one of the smallest peptides in the melanocortin family and one of the most-studied anti-inflammatory research tripeptides. It is supplied as a high-purity lyophilized powder. KPV is uitsluitend voor laboratoriumonderzoek and is not intended for human or veterinary diagnosis or therapy. For mechanism, IBD research history, and stacking context, see our KPV research guide.

Mechanism of Action — Three Anti-Inflammatory Pathways

KPV’s anti-inflammatory activity operates through at least three complementary pathways, all of which converge on reducing inflammatory signaling without affecting other melanocortin functions:

• NFkB inhibition — KPV blocks the translocation of NFkB into the nucleus, preventing transcription of pro-inflammatory cytokines including TNF-alpha, IL-6, IL-1β, and IL-8. NFkB is the master regulator of inflammatory gene expression, so blocking its activation produces a broad, upstream anti-inflammatory effect.
• Mast-cell stabilization — KPV reduces mast-cell degranulation and histamine release in research models. This is a distinct mechanism from NFkB inhibition and is particularly relevant to allergic-inflammation research and topical skin-inflammation models.
• Peptide-vs-MSH separation — because KPV is only the C-terminal fragment, it does not activate MC1R (the pigmentation receptor) or MC4R (the arousal/feeding receptor). This mechanistically separates the anti-inflammatory activity from α-MSH’s other effects — distinct from broader MC analogs such as Melanotan II of PT-141.

The practical research implication: KPV is a “clean” anti-inflammatory research tool that produces the α-MSH anti-inflammatory signal without the tanning, arousal, or appetite-modulation effects that complicate interpretation of research using full-length MC agonists.

Published Research Applications

KPV is used in laboratory research contexts that investigate:

• IBD and colitis research — inflammatory bowel disease rodent models; KPV is active via both SC and oral routes, making it unusually flexible for GI-inflammation research (Brzoska et al., Endocr Rev 2008)
• Allergic inflammation — mast-cell stabilization and histamine-release research in allergy and atopy models
• Skin inflammation — eczema, psoriasis, and contact-dermatitis research models; topical formulations appear in some research protocols
• Wound healing — anti-inflammatory phase of wound-healing research, often paired with BPC-157 for combined anti-inflammatory and growth-factor coverage
• Joint inflammation — arthritis and joint-inflammation rodent research models
• Stacking research — commonly paired with BPC-157 in GI and connective-tissue research where anti-inflammatory + tissue-repair coverage is needed
• Melanocortin comparative research — side-by-side with Melanotan II en PT-141 to isolate the pure anti-inflammatory vs MC-receptor effects

For broader context on anti-inflammatory and healing peptides see the onderzoekspeptiden catalogus.

Beschikbare sterktes en concentraties

MedsBase stocks KPV in the following lyophilized vial sizes:

KPV research protocols span a range depending on model system — 200–500 mcg SC daily for systemic anti-inflammatory research, or topical/oral routes for GI and skin research contexts. All strengths are supplied as lyophilized powder at 99%+ HPLC purity.

How It Compares — KPV vs Other Anti-Inflammatory / Melanocortin Peptides

KPV is one of the cleanest anti-inflammatory peptides in research use because its activity is so narrow. Compared to related compounds:

For GI-inflammation research, KPV + BPC-157 is a particularly common combination because KPV provides upstream anti-inflammatory signaling while BPC-157 provides tissue-repair growth-factor activity. This is covered in our BPC-157 onderzoeksgids.

Opslag en Reconstituering

Voor reconstituering: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.

Reconstitueringsprocedure: inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently — do niet shake — and allow 5–10 minutes for full dissolution. Solution should be clear and colourless.

Na reconstitutie: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution.

Veelgestelde vragen

What is KPV used for in research?

KPV is used in laboratory research investigating anti-inflammatory biology, inflammatory bowel disease (IBD) and colitis, allergic inflammation, skin inflammation (eczema/psoriasis models), wound-healing inflammation phase, joint inflammation, and comparative melanocortin pharmacology. It is niet FDA-approved and is sold here strictly for laboratory research use only.

How is KPV different from Melanotan II or PT-141?

KPV is only the three-amino-acid C-terminal fragment of alpha-MSH, whereas Melanotan II and PT-141 are full-length or near-full cyclic MSH analogs. This means KPV has no melanocortin-receptor activity and therefore no pigmentation (MC1R), arousal (MC4R), or appetite (MC4R) effects — only anti-inflammatory activity via NFkB and mast-cell pathways.

What is the typical KPV research dose?

Published preclinical protocols typically use 200–500 mcg SC daily for systemic anti-inflammatory research. Some IBD and skin-inflammation research uses oral or topical administration. A 10 mg vial reconstituted with 2.0 mL bacteriostatic water yields 5 mg/mL — 10 ticks on a U-100 SC syringe delivers 500 mcg.

Is KPV FDA approved?

No. KPV has not received FDA, EMA, or any regulatory approval. The full alpha-MSH peptide and KPV-related research has informed melanocortin drug development broadly, but KPV itself remains research-use-only. All KPV sold by peptide-research suppliers is for laboratory investigation only.

Can KPV be taken orally for IBD research?

Yes. Unlike most peptides which are degraded by gastric enzymes, KPV retains some anti-inflammatory activity via the oral route in published IBD and colitis research. This makes it unusually flexible for GI-inflammation research where oral delivery targets the GI tract directly. Research protocols vary by model — SC remains the dominant systemic route.

How should KPV be stored?

Lyophilized vials: refrigerated at 2–8 °C in original packaging, stable up to 36 months. Reconstituted solution: refrigerated at 2–8 °C, use within 30 days. Do not freeze reconstituted solution.

How do I reconstitute KPV?

Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do niet shake.

Can KPV and BPC-157 be stacked in research?

Yes — this is one of the most common research combinations for GI and connective-tissue inflammation. KPV provides upstream NFkB-pathway anti-inflammatory signaling; BPC-157 provides VEGF-pathway tissue-repair and growth-factor activity. The mechanisms are complementary rather than overlapping.

Welke sterktes heeft MedsBase op voorraad?

MedsBase carries KPV in 5 mg and 10 mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.

Does KPV cause side effects in research?

Published preclinical research has reported a notably clean safety profile. Because KPV has no melanocortin-receptor activity, the pigmentation, arousal, and blood-pressure effects sometimes seen with full MC agonists do not occur with KPV. No significant off-target signals have been identified at typical research doses. Long-term human safety data are not available.

What is the half-life of KPV?

KPV (Lys-Pro-Val) is a tripeptide with a short plasma half-life consistent with small unmodified peptides — estimated at under 30 minutes. Its primary research application is gastrointestinal, where local delivery studies show effects on gut epithelial cells and immune cell populations that persist beyond plasma detection, attributed to direct receptor interaction at the intestinal mucosa.

How does KPV reduce inflammation in research models?

KPV is the C-terminal tripeptide of α-MSH (alpha-melanocyte stimulating hormone) and retains much of the parent peptide’s anti-inflammatory activity via MC1R activation. In colitis and gut injury models, KPV reduces NF-κB signalling, decreases pro-inflammatory cytokine production (IL-1β, IL-6, TNF-α), and promotes intestinal epithelial barrier integrity. Its small size facilitates direct epithelial cell uptake independent of carrier proteins.

Can I order KPV for international shipping?

Yes. MedsBase ships KPV worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.

Andere Peptiden voor Herstel- en Prestatieonderzoek

• BPC-157 — Body Protection Compound — onderzoek naar pees-, ligament- en darmherstel
• TB-500 — Thymosine Beta-4 fragment — onderzoek naar zacht weefsel en vasculair herstel
• Ipamorelin — Selectieve ghreline-agonist — schone GH-puls zonder cortisol/prolactine
• CJC-1295 met DAC — GHRH-analoog met verlengde halfwaardetijd
• GHK-Cu — Koperpeptide — onderzoek naar huid- en bindweefselregeneratie

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