SNAP-8 (Acetyl Octapeptide-3) — Research Grade
✅ Synthetic 8-aa SNAP-25-mimetic SNARE-complex inhibitor
✅ Sequence Ac-EEMQRRADA-OH; extends Argireline (6-aa) for stronger SNARE binding
✅ Topical ‘Botox-like’ acetylcholine-release reduction at NMJ
✅ Canonical cosmeceutical anti-aging research peptide (Lipotec)
✅ CAS 868844-74-0; MW 1078.13
SNAP-8 (Acetyl Octapeptide-3) contains synthetic SNARE-complex-inhibiting research peptide.
✓ Medisch beoordeeld door Morgan Ellis — Apotheekonderzoeker · 8 jaar ervaring · Laatst beoordeeld: mei 2026
Quick Answer — What is SNAP-8 (Acetyl Octapeptide-3)?
SNAP-8 (also called Acetyl Octapeptide-3 of Acetyl Glutamyl Octapeptide-3, CAS 868844-74-0) is a synthetic 8-amino-acid SNAP-25-mimetic peptide: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-OH (Ac-EEMQRRADA-OH). Molecular formula C40H68N14O17S, MW 1,078.13 g/mol. SNAP-8 mimics the N-terminal end of SNAP-25 — a SNARE-complex protein required for neurotransmitter exocytosis at the neuromuscular junction (and the molecular target of botulinum toxin / Botox). The mimetic competes with native SNAP-25 for binding to the SNARE complex, reducing assembly of the vesicle-fusion machinery and producing a “topical botulinum-like” effect — reduced acetylcholine release at neuromuscular junctions. Originally developed and patented by Lipotec (Spain); widely cited in cosmeceutical research and as a topical-application alternative to injectable botulinum toxin. For laboratory research use only.
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| Specificatie | Detail |
|---|---|
| Compound Class | Synthetic 8-aa SNAP-25-mimetic peptide; SNARE-complex inhibitor; cosmeceutical / topical-application research peptide |
| Chemical Name | Acetyl Octapeptide-3 (synonyms: SNAP-8, Acetyl Glutamyl Octapeptide-3, Argireline-NG; INCI: Acetyl Octapeptide-3) |
| CAS-nummer | 868844-74-0 |
| Sequentie | Acetyl-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-OH (Ac-EEMQRRADA-OH; 8 amino acids; N-terminal acetylation for stability) |
| Molecular Formula / MW | C40H68N14O17S; MW 1,078.13 g/mol |
| Werkingsmechanisme | Mimics the N-terminal of SNAP-25, a SNARE-complex protein required for neurotransmitter vesicle docking and fusion at the synapse. SNAP-8 competes with native SNAP-25 for binding to the SNARE complex (with syntaxin and VAMP / synaptobrevin), reducing functional SNARE assembly and inhibiting acetylcholine release at neuromuscular junctions. The result is “topical botulinum-like” reduction of muscle-fibre activation, primarily applied to facial-expression muscles in cosmeceutical contexts. |
| SNAP-8 vs Argireline (Acetyl Hexapeptide-8) | SNAP-8 is the 8-residue extension of Argireline (Acetyl Hexapeptide-8, 6-aa). The additional two N-terminal glutamate residues provide enhanced SNARE-complex binding affinity (~2-3× more active than Argireline per Lipotec patent data) and improved skin-penetration kinetics in topical applications. |
| Form / Purity / Storage | Lyophilized white-to-off-white powder; ≥99% HPLC, COA on request. Store at 2–8 °C (short-term) or −20 °C (long-term, ≥36 months). Reconstituted aqueous: 2–8 °C, use within 30 days. |
| Onderzoeksgebruik | For laboratory research use only. Not for human or veterinary diagnostic or therapeutic use. Used in topical-cosmetic and skin-penetration research; not on the WADA Prohibited List. |
Mechanism of Action — SNARE Complex Inhibition
SNAP-25 is one of three core proteins of the neuronal SNARE complex (alongside syntaxin-1 and synaptobrevin/VAMP-2). The SNARE complex catalyses the fusion of synaptic vesicles with the presynaptic plasma membrane — releasing the vesicular content (acetylcholine at neuromuscular junctions, other neurotransmitters at central synapses) into the synaptic cleft. SNAP-25 is also the molecular target cleaved by botulinum toxin types A and E — explaining how Botox produces its neuromuscular-paralysis effect.
SNAP-8 / Acetyl Octapeptide-3 mimics the first 8 residues of SNAP-25’s N-terminal helix. By binding to the SNARE-complex assembly site, SNAP-8 competes with intact native SNAP-25 — partially reducing functional SNARE-complex formation and therefore reducing the amount of acetylcholine released per nerve impulse. The net consequence at facial-expression muscles is reduced contraction amplitude and reduced expression-line formation — the basis for SNAP-8’s cosmeceutical use as a topical anti-wrinkle peptide.
Published Research Applications
- Cosmeceutical anti-aging research — the canonical “topical Botox alternative” in published cosmetic-pharmacology literature
- SNARE-complex pharmacology — competitive binding studies, in-vitro SNARE-assembly kinetics
- Neuromuscular junction research — acetylcholine-release inhibition studies
- Skin-penetration peptide research — extended length vs Argireline confers better penetration kinetics
- Comparative cosmeceutical peptide research — head-to-head with Argireline (Acetyl Hexapeptide-8) and other SNAP-25-mimetic peptides
For broader context on cosmetic / aesthetic research peptides, see GHK-Cu (copper tripeptide — collagen / skin remodelling), Melanotan II (MC1R/MC4R agonist — tanning research), AHK-Cu (alternative copper peptide). Browse the full peptide research catalog.
Available Strengths
| Vulsterkte | Verpakkingsgroottes |
|---|---|
| 10 mg — standard research strength for topical formulation, in-vitro SNARE-assembly studies | 10 of 20 flesjes |
| 100 mg — high-strength research vial for formulation development; lowest per-mg cost | 10 of 20 flesjes |
Opslag en Reconstituering
Store lyophilized vials at 2–8 °C; −20 °C for long-term. Reconstitute in sterile water or bacteriostatic water (water-soluble at multi-mg/mL concentrations). Store reconstituted at 2–8 °C, use within 30 days. Avoid repeated freeze-thaw.
FAQ
How is SNAP-8 different from Argireline (Acetyl Hexapeptide-8)?
Argireline is the 6-aa version (Acetyl Hexapeptide-8 / Ac-EEMQRR-NH2). SNAP-8 is the extended 8-aa version (Acetyl Octapeptide-3 / Ac-EEMQRRADA-OH) with two additional residues that improve SNARE-complex binding affinity and skin-penetration kinetics.
Can SNAP-8 produce a Botox-like effect topically?
SNAP-8 is the most-cited “topical Botox” research peptide, but the mechanistic effect is partial and slow compared with injectable botulinum toxin. Topical SNAP-8 reduces expression-line formation but does not produce the dramatic paralysis effect of injected Botox. Published cosmeceutical research has demonstrated measurable but modest wrinkle-reduction over 4–8 weeks of daily topical application.
What dose ranges are used in research?
Cosmeceutical formulations typically use 5–10% w/w SNAP-8 in topical cream / serum bases. In-vitro SNARE-assembly studies use micromolar to millimolar peptide concentrations.
Other Cosmetic / Aesthetic Research Peptides
- GHK-Cu — Copper tripeptide — collagen / skin remodelling research
- AHK-Cu — Alternative copper peptide
- Melanotan II — MC1R/MC4R agonist — pigmentation research
- PT-141 (Bremelanotide) — Melanocortin receptor agonist
- BPC-157 — Tissue-repair pentadecapeptide
- BAC Water (Bacteriostatisch Water) — Required for reconstituting any lyophilized vial — sterile, 0.9% benzyl-alcohol-preserved diluent
Meer opties in Peptiden
Gerangschikt op recente bestelvolumes van MedsBase — wat andere klanten in deze categorie kiezen.
| Sterkte | 10 mg, 100 mg |
|---|---|
| Hoeveelheid | 10 flacons, 20 flacons, 30 flacons |
SNAP-8 (Acetyl Octapeptide-3) — Research Grade
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SNAP-8 (Acetyl Octapeptide-3) — Research Grade
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