Ipamorelin

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What Is Ipamorelin?

Ipamorelin is a synthetic pentapeptide belonging to the growth-hormone-releasing peptide (GHRP) family. Developed by Novo Nordisk in the 1990s and first characterised by Raun et al. (Eur J Endocrinol, 1998), it is classified as a growth hormone secretagogue — a compound that triggers endogenous GH release by activating the ghrelin receptor (GHS-R1a) on pituitary somatotropes.

Sequence: Aib-His-D-2-Nal-D-Phe-Lys-NH₂. Molecular weight approximately 711.9 Da. Unlike earlier GHRPs (GHRP-2, GHRP-6, hexarelin), ipamorelin is remarkable for its clean hormonal selectivity — it releases GH without meaningfully raising cortisol, prolactin, or ACTH. This selectivity is why ipamorelin has become the most-studied GHRP of the 21st century. It is supplied as a high-purity lyophilized powder for reconstitution with bacteriostatic water. Ipamorelin is uitsluitend voor laboratoriumonderzoek and is not intended for human or veterinary diagnosis or therapy. For mechanism, published research, and stacking protocols, see our Ipamorelin & CJC-1295 research guide.

Mechanism of Action — Selective Ghrelin-Receptor Agonism

Ipamorelin binds the growth hormone secretagogue receptor type 1a (GHS-R1a), the endogenous receptor for ghrelin. The receptor is expressed on pituitary somatotropes and in the hypothalamic arcuate nucleus, and activation triggers a pulsatile release of growth hormone from pituitary storage granules.

• Pulsatile GH release — unlike continuous recombinant GH administration, ipamorelin produces a pulsatile GH profile that more closely mimics endogenous nocturnal GH bursts. This pulsatility is important mechanistically because IGF-1 signaling is more responsive to pulsed than continuous GH exposure.
• Clean hormonal selectivity — the defining feature of ipamorelin. Older GHRPs (GHRP-2, GHRP-6, hexarelin) also raise cortisol and prolactin, producing off-target effects that complicate research interpretation. Ipamorelin does not, making it the preferred GHRP for research where those confounders matter.
• GHRH complementarity — ipamorelin acts via the ghrelin-receptor pathway; GHRH analogs such as CJC-1295 act via a parallel GHRH-receptor pathway. Co-administration produces synergistic GH pulse amplification greater than either peptide alone — the basis of the classic “ipamorelin + CJC-1295” research stack.

Because ipamorelin works through the body’s own pituitary GH supply, it is subject to normal negative-feedback regulation by somatostatin and IGF-1. This auto-regulation is a research-relevant safety feature distinguishing secretagogues from exogenous recombinant GH.

Published Research Applications

Ipamorelin is used in laboratory research contexts that investigate:

• GH pulse research — pulsatile growth-hormone release kinetics and IGF-1 response in rodent models (Raun et al., Eur J Endocrinol 1998)
• Skeletal muscle recovery — post-injury and post-exercise recovery, often stacked with BPC-157 en TB-500
• Body composition research — lean-mass preservation and fat-mass research, often in caloric-deficit or disuse-atrophy models
• Sleep research — slow-wave sleep and nocturnal GH-surge research; pre-sleep dosing is the typical research timing
• Bone density research — osteoblast activity and bone mineral density via GH/IGF-1 axis modulation
• CJC-1295 stacking research — synergistic GH amplification protocols with GHRH analogs (see the Ipamorelin + CJC-1295 stack guide)

For broader context on the GH-axis peptide landscape, see the research peptides catalog.

Beschikbare sterktes en concentraties

MedsBase stocks ipamorelin in the following lyophilized vial sizes. Each variation ships in 10-vial, 20-vial, or 30-vial pack formats:

All three strengths are the same chemical form (lyophilized powder, 99%+ HPLC purity). A 5 mg vial at 2.5 mg/mL dilution delivers approximately 16 administrations of 300 mcg, matching common research protocols.

How It Compares — Ipamorelin vs CJC-1295

Ipamorelin and CJC-1295 met DAC are the two most-studied GH-axis peptides. They are near-universally co-administered rather than substituted, because they act on parallel receptor systems that produce synergy together:

The full stacking rationale, dose-timing, and synergy-mechanism analysis are in our Ipamorelin and CJC-1295 stack research guide.

Opslag en Reconstituering

Voor reconstituering: store lyophilized vials refrigerated at 2–8 °C in original packaging, stable up to 36 months. Avoid freeze-thaw cycles on the powder.

Reconstitueringsprocedure: inject bacteriostatic water down the side wall of the peptide vial per the chart above. Swirl gently — do niet shake — and allow 5–10 minutes for full dissolution. A correctly reconstituted solution should be clear and colourless.

Na reconstitutie: store refrigerated at 2–8 °C and use within 30 days. Do not freeze reconstituted solution — freeze-thaw cycles degrade peptide integrity.

Veelgestelde vragen

What is ipamorelin used for in research?

Ipamorelin is used in laboratory research investigating pulsatile growth hormone release, IGF-1 axis signaling, skeletal muscle recovery, body composition, sleep research, bone density, and GH-axis stacking with GHRH analogs. It is niet FDA-approved and is sold here strictly for laboratory research use only.

What is the typical ipamorelin research dose?

Published preclinical protocols typically use 200–300 mcg per administration, 2–3 times daily, often with one dose timed pre-sleep to align with nocturnal GH-surge research. A 5 mg vial reconstituted with 2.0 mL bacteriostatic water yields 2.5 mg/mL — 12 ticks on a U-100 syringe delivers 300 mcg.

How is ipamorelin different from CJC-1295?

Ipamorelin is a GHRP (growth-hormone-releasing peptide) that binds the ghrelin receptor for pulsatile GH release. CJC-1295 is a GHRH (growth-hormone-releasing hormone) analog that binds a different receptor on the same pituitary cells for sustained GH elevation. The two are typically stacked because their mechanisms are additive/synergistic.

Is ipamorelin FDA approved?

No. Ipamorelin is not approved by the FDA, EMA, MHRA, or any other regulator for human therapeutic use. It has been studied in early-phase human clinical trials but never advanced to approval. All ipamorelin sold by research-use-only suppliers is for laboratory investigation only.

Why is ipamorelin preferred over older GHRPs like GHRP-6?

Ipamorelin’s defining feature is clean hormonal selectivity — it releases GH without raising cortisol, prolactin, or ACTH. Older GHRPs (GHRP-2, GHRP-6, hexarelin) raise all three, producing off-target effects that complicate research interpretation and produce unwanted side effects. This selectivity has made ipamorelin the most-studied GHRP of the past two decades.

How should ipamorelin be stored?

Gevriesdroogde flesjes: gekoeld bewaren bij 2–8 °C in de originele verpakking, stabiel tot 36 maanden. Oplossing na reconstitutie: gekoeld bewaren bij 2–8 °C, binnen 30 dagen gebruiken. Vries de gereconstitueerde oplossing niet in — vries-ontdooicycli degraderen het peptide.

How do I reconstitute ipamorelin?

Follow the reconstitution chart above. Add bacteriostatic water down the side wall of the vial, swirl gently, and allow 5–10 minutes for full dissolution. Do niet shake the vial.

Can ipamorelin and CJC-1295 be stacked in research?

Yes. The ipamorelin + CJC-1295 combination is the canonical GH-axis research stack. The two peptides act on parallel receptor systems (ghrelin vs GHRH receptor) and their effects on GH release are synergistic — combined use produces larger GH pulses than either alone. See our stack guide.

Welke sterktes heeft MedsBase op voorraad?

MedsBase carries ipamorelin in 2 mg, 5 mg, and 10 mg lyophilized vials. Each strength is available in 10-vial, 20-vial, or 30-vial pack sizes. All vials are supplied at 99%+ HPLC purity with a certificate of analysis on request.

Does ipamorelin cause side effects in research?

Ipamorelin has been reported with a clean safety profile at typical research doses. Its selective receptor binding avoids the cortisol and prolactin elevation seen with older GHRPs. Long-term human safety data are not available because human trials were not completed.

Why is pre-sleep timing used in ipamorelin research?

Endogenous growth-hormone release is naturally pulsatile and strongest during slow-wave sleep. Research protocols typically time one ipamorelin dose 30–60 minutes before sleep to amplify the natural nocturnal GH surge rather than compete with daytime somatostatin tone.

What is the half-life of Ipamorelin?

Ipamorelin has a short plasma half-life of approximately 2 hours in preclinical research, consistent with the broader GHRP peptide class. This rapid clearance underpins the pulsatile, multiple-daily dosing schedules most commonly used in ipamorelin research protocols.

How does Ipamorelin compare to GHRP-6 in research?

Ipamorelin is highly selective for the GHSR-1a receptor and does not significantly elevate cortisol or prolactin in preclinical studies — a key distinction from GHRP-6, which activates ghrelin receptors more broadly and is associated with transient cortisol and prolactin increases. This selectivity is a primary reason ipamorelin is frequently preferred in published GH-secretagogue research.

Can I order ipamorelin for international shipping?

Yes. MedsBase ships ipamorelin worldwide from our dedicated peptide shipping network. Peptide-only orders qualify for our standalone peptide shipping service. Orders ship in temperature-controlled packaging with full tracking.

If your recovery protocol pairs ipamorelin’s GH-pulse stimulation with direct tissue-repair peptides for tendon or ligament work, our Peptide Healing Stack (BPC-157 5 mg + TB-500 5 mg) covers the angiogenesis + cytoskeletal-repair side of the regimen with bacteriostatic water included for reconstitution.

Andere Peptiden voor Herstel- en Prestatieonderzoek

• BPC-157 — Body Protection Compound — onderzoek naar pees-, ligament- en darmherstel
• TB-500 — Thymosine Beta-4 fragment — onderzoek naar zacht weefsel en vasculair herstel
• CJC-1295 met DAC — GHRH-analoog met verlengde halfwaardetijd
• GHK-Cu — Koperpeptide — onderzoek naar huid- en bindweefselregeneratie
• IGF-1 LR3 — Long-R3 IGF-1 analog — anabolic / regenerative research

Verder lezen

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